Metal-organic frameworks for the storage and delivery of biologically active hydrogen sulfide

Phoebe K Allan; Paul S Wheatley; David Aldous; M Infas Mohideen; Chiu Tang; Joseph A Hriljac; Ian L Megson; Karena W Chapman; Guy De Weireld; Sebastian Vaesen; Russell E Morris

doi:10.1039/c2dt12069k

Metal-organic frameworks for the storage and delivery of biologically active hydrogen sulfide

Phoebe K Allan, Paul S Wheatley, David Aldous, M Infas Mohideen, Chiu Tang, Joseph A Hriljac, Ian L Megson, Karena W Chapman, Guy De Weireld, Sebastian Vaesen, Russell E Morris

Research output: Contribution to journal › Article › peer-review

134 Citations (Scopus)

Abstract

Hydrogen sulfide is an extremely toxic gas that is also of great interest for biological applications when delivered in the correct amount and at the desired rate. Here we show that the highly porous metal-organic frameworks with the CPO-27 structure can bind the hydrogen sulfide relatively strongly, allowing the storage of the gas for at least several months. Delivered gas is biologically active in preliminary vasodilation studies of porcine arteries, and the structure of the hydrogen sulfide molecules inside the framework has been elucidated using a combination of powder X-ray diffraction and pair distribution function analysis.

Original language	English
Pages (from-to)	4060-6
Number of pages	7
Journal	Dalton transactions (Cambridge, England : 2003)
Volume	41
Issue number	14
DOIs	https://doi.org/10.1039/c2dt12069k
Publication status	Published - 2012

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title = "Metal-organic frameworks for the storage and delivery of biologically active hydrogen sulfide",

abstract = "Hydrogen sulfide is an extremely toxic gas that is also of great interest for biological applications when delivered in the correct amount and at the desired rate. Here we show that the highly porous metal-organic frameworks with the CPO-27 structure can bind the hydrogen sulfide relatively strongly, allowing the storage of the gas for at least several months. Delivered gas is biologically active in preliminary vasodilation studies of porcine arteries, and the structure of the hydrogen sulfide molecules inside the framework has been elucidated using a combination of powder X-ray diffraction and pair distribution function analysis.",

author = "Allan, {Phoebe K} and Wheatley, {Paul S} and David Aldous and Mohideen, {M Infas} and Chiu Tang and Hriljac, {Joseph A} and Megson, {Ian L} and Chapman, {Karena W} and {De Weireld}, Guy and Sebastian Vaesen and Morris, {Russell E}",

year = "2012",

doi = "10.1039/c2dt12069k",

language = "English",

volume = "41",

pages = "4060--6",

journal = "Dalton transactions (Cambridge, England : 2003)",

issn = "1477-9234",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Metal-organic frameworks for the storage and delivery of biologically active hydrogen sulfide

AU - Allan, Phoebe K

AU - Wheatley, Paul S

AU - Aldous, David

AU - Mohideen, M Infas

AU - Tang, Chiu

AU - Hriljac, Joseph A

AU - Megson, Ian L

AU - Chapman, Karena W

AU - De Weireld, Guy

AU - Vaesen, Sebastian

AU - Morris, Russell E

PY - 2012

Y1 - 2012

N2 - Hydrogen sulfide is an extremely toxic gas that is also of great interest for biological applications when delivered in the correct amount and at the desired rate. Here we show that the highly porous metal-organic frameworks with the CPO-27 structure can bind the hydrogen sulfide relatively strongly, allowing the storage of the gas for at least several months. Delivered gas is biologically active in preliminary vasodilation studies of porcine arteries, and the structure of the hydrogen sulfide molecules inside the framework has been elucidated using a combination of powder X-ray diffraction and pair distribution function analysis.

AB - Hydrogen sulfide is an extremely toxic gas that is also of great interest for biological applications when delivered in the correct amount and at the desired rate. Here we show that the highly porous metal-organic frameworks with the CPO-27 structure can bind the hydrogen sulfide relatively strongly, allowing the storage of the gas for at least several months. Delivered gas is biologically active in preliminary vasodilation studies of porcine arteries, and the structure of the hydrogen sulfide molecules inside the framework has been elucidated using a combination of powder X-ray diffraction and pair distribution function analysis.

U2 - 10.1039/c2dt12069k

DO - 10.1039/c2dt12069k

M3 - Article

C2 - 22378060

SN - 1477-9234

VL - 41

SP - 4060

EP - 4066

JO - Dalton transactions (Cambridge, England : 2003)

JF - Dalton transactions (Cambridge, England : 2003)

IS - 14

ER -

Metal-organic frameworks for the storage and delivery of biologically active hydrogen sulfide

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