Mechanisms for an effect of acetylcysteine on renal function after exposure to radio-graphic contrast material: study protocol

Euan A Sandilands, Sharon Cameron, Frances Paterson, Sam Donaldson, Lesley Briody, Jane Crowe, Julie Donnelly, Adrian Thompson, Neil R Johnston, Ivor Mackenzie, Neal Uren, Jane Goddard, David J Webb, Ian L Megson, Nicholas Bateman, Michael Eddleston

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Contrast-induced nephropathy is a common complication of contrast administration in patients with chronic kidney disease and diabetes. Its pathophysiology is not well understood; similarly the role of intravenous or oral acetylcysteine is unclear. Randomized controlled trials to date have been conducted without detailed knowledge of the effect of acetylcysteine on renal function. We are conducting a detailed mechanistic study of acetylcysteine on normal and impaired kidneys, both with and without contrast. This information would guide the choice of dose, route, and appropriate outcome measure for future clinical trials in patients with chronic kidney disease.
Original languageEnglish
Pages (from-to)3
JournalBMC Clinical Pharmacology
Volume12
DOIs
Publication statusPublished - 2012

Fingerprint Dive into the research topics of 'Mechanisms for an effect of acetylcysteine on renal function after exposure to radio-graphic contrast material: study protocol'. Together they form a unique fingerprint.

  • Cite this

    Sandilands, E. A., Cameron, S., Paterson, F., Donaldson, S., Briody, L., Crowe, J., Donnelly, J., Thompson, A., Johnston, N. R., Mackenzie, I., Uren, N., Goddard, J., Webb, D. J., Megson, I. L., Bateman, N., & Eddleston, M. (2012). Mechanisms for an effect of acetylcysteine on renal function after exposure to radio-graphic contrast material: study protocol. BMC Clinical Pharmacology, 12, 3. https://doi.org/10.1186/1472-6904-12-3