Is the polymorphic microsatellite repeat of the dopamine beta-hydroxylase gene associated with biochemical variability of the catecholamine pathway in schizophrenia?

J Wei, H M Xu, C N Ramchand, G P Hemmings

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Abstract

Six allelic fragments were typed by a polymerase chain reaction process with a pair of primers specific for a sequence containing the polymorphic (GT)n repeat, a microsatellite repeat, in the human dopamine beta-hydroxylase (DBH) gene. Their frequencies in unrelated patients with schizophrenia were 0.003 (A1), 0.114 (A2), 0.343 (A3), 0.526 (A4), 0.006 (A5), and 0.009 (A6), and in unrelated control subjects, 0.012 (A1), 0.086 (A2), 0.309 (A3), 0.574 (A4), 0.006 (A5), and 0.012 (A6). Kruskal-Wallis analysis revealed significant differences among the three groups, the drug-free and drug-treated patients, and the control subjects, in serum DBH activity of the subjects whose genotype was A2/A3 (H = 6.0, p
Original languageEnglish
Pages (from-to)762-7
Number of pages6
JournalBiological Psychiatry
Volume41
Issue number7
DOIs
Publication statusPublished - 1 Apr 1997

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Keywords

  • Adult
  • Alleles
  • Brain
  • Catecholamines
  • Dopamine beta-Hydroxylase
  • Female
  • Gene Expression Regulation, Enzymologic
  • Gene Frequency
  • Genotype
  • Humans
  • Male
  • Microsatellite Repeats
  • Middle Aged
  • Neural Pathways
  • Polymerase Chain Reaction
  • Polymorphism, Genetic
  • Schizophrenia

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