Abstract
This study sought to establish whether functional analysis of the ATM-p53-p21 pathway adds to the information provided by currently available prognostic factors in patients with chronic lymphocytic leukemia (CLL) requiring frontline chemotherapy.
Original language | English |
---|---|
Pages (from-to) | 4191-200 |
Number of pages | 10 |
Journal | Clinical Cancer Research : An Official Journal of the American Association for Cancer Research |
Volume | 18 |
Issue number | 15 |
DOIs | |
Publication status | Published - 1 Aug 2012 |
Keywords
- Aged
- Antineoplastic Combined Chemotherapy Protocols
- Ataxia Telangiectasia Mutated Proteins
- Cell Cycle Proteins
- Chlorambucil
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclophosphamide
- DNA-Binding Proteins
- Female
- Flow Cytometry
- Humans
- Leukemia, Lymphocytic, Chronic, B-Cell
- Leukocytes, Mononuclear
- Male
- Middle Aged
- Mutation
- Prognosis
- Protein-Serine-Threonine Kinases
- Randomized Controlled Trials as Topic
- Signal Transduction
- Survival Analysis
- Tumor Suppressor Protein p53
- Tumor Suppressor Proteins
- Vidarabine