TY - JOUR
T1 - Exploring the chemical space of macro-and micro-algae using comparative metabolomics
AU - Hughes, Alison H.
AU - Magot, Florent
AU - Tawfike, Ahmed F.
AU - Rad-Menéndez, Cecilia
AU - Thomas, Naomi
AU - Young, Louise C.
AU - Stucchi, Laura
AU - Carettoni, Daniele
AU - Stanley, Michele S.
AU - Edrada-Ebel, Ruangelie
AU - Duncan, Katherine R.
N1 - Funding Information:
Funding: The research leading to these results received funding from the European Union Seventh Framework Program under grant agreement number 311932 (project SeaBioTech). Authors A.H.H. and K.R.D. acknowledge the support of the Industrial Biotechnology Innovation Centre (IBioIC) for a PhD studentship supporting A.H.H., K.R.D. and M.S.S. acknowledge funding from a BBSRC NIBB PHYCONET Proof of Concept grant PHYCPoC-32.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/2/3
Y1 - 2021/2/3
N2 - With more than 156,000 described species, eukaryotic algae (both macro-and micro-algae) are a rich source of biological diversity, however their chemical diversity remains largely unexplored. Specialised metabolites with promising biological activities have been widely reported for seaweeds, and more recently extracts from microalgae have exhibited activity in anticancer, antimicrobial, and antioxidant screens. However, we are still missing critical information on the distinction of chemical profiles between macro-and microalgae, as well as the chemical space these metabolites cover. This study has used an untargeted comparative metabolomics approach to explore the chemical diversity of seven seaweeds and 36 microalgal strains. A total of 1390 liquid chromatography-mass spectrometry (LC-MS) features were detected, representing small organic algal metabolites, with no overlap between the seaweeds and microalgae. An in-depth analysis of four Dunaliella tertiolecta strains shows that environmental factors may play a larger role than phylogeny when classifying their metabolomic profiles.
AB - With more than 156,000 described species, eukaryotic algae (both macro-and micro-algae) are a rich source of biological diversity, however their chemical diversity remains largely unexplored. Specialised metabolites with promising biological activities have been widely reported for seaweeds, and more recently extracts from microalgae have exhibited activity in anticancer, antimicrobial, and antioxidant screens. However, we are still missing critical information on the distinction of chemical profiles between macro-and microalgae, as well as the chemical space these metabolites cover. This study has used an untargeted comparative metabolomics approach to explore the chemical diversity of seven seaweeds and 36 microalgal strains. A total of 1390 liquid chromatography-mass spectrometry (LC-MS) features were detected, representing small organic algal metabolites, with no overlap between the seaweeds and microalgae. An in-depth analysis of four Dunaliella tertiolecta strains shows that environmental factors may play a larger role than phylogeny when classifying their metabolomic profiles.
KW - Bioactivity
KW - Biotechnology
KW - Comparative metabolomics
KW - Mass spectrometry
KW - Microalgae
KW - Microalgal metabolites
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U2 - 10.3390/microorganisms9020311
DO - 10.3390/microorganisms9020311
M3 - Article
AN - SCOPUS:85100248426
SN - 2076-2607
VL - 9
SP - 1
EP - 16
JO - Microorganisms
JF - Microorganisms
IS - 2
M1 - 311
ER -