Evidence for sltA1 as a salt-sensitive allele of the arginase gene (agaA) in the ascomycete Aspergillus nidulans

D. J. Clement, M. S. Stanley, N. A. Attwell, N. J.W. Clipson, D. A. Fincham, P. Hooley

Research output: Contribution to journalArticlepeer-review

Abstract

Strains of Aspergillus nidulans carrying the sltA1 mutation, conferring sensitivity to KCl and NaCl, also showed an arginine-sensitive phenotype whereby concentrations of the L-amino acid at or above 10 mM were toxic to growth. Sexual progeny of a cross between a sltA1 mutant and a wild-type strain showed a co-segregation of salt and arginine sensitivity. Sim-ilarly, revertants to salt tolerance showed a loss of arginine sensitivity as did sltA1 strains that were transformed with a cosmid carrying the putative sltA1+ wild-type allele. In addition, arginine sensitivity could be relieved by L-ornithine. It is suggested that sltA1 is a salt-sensitive allele of the arginase gene (agaA).

Original languageEnglish
Pages (from-to)462-467
Number of pages6
JournalCurrent Genetics
Volume29
Issue number5
DOIs
Publication statusPublished - 1 Apr 1996

Keywords

  • A. nidulans
  • Arginase
  • Salt sensitivity

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