Effects of acute methionine loading and vitamin C on endogenous fibrinolysis, endothelium-dependent vasomotion and platelet aggregation

C Labinjoh, D E Newby, I B Wilkinson, I L Megson, H MacCallum, V Melville, N A Boon, D J Webb

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Abstract

We assessed forearm blood flow and plasma fibrinolytic factors in eight healthy males who received unilateral brachial artery infusions of the endothelium-dependent vasodilator, substance P, and the endothelium-independent vasodilator, sodium nitroprusside. These measurements, together with platelet aggregation studies, were performed on four occasions after double-blind randomized ingestion of placebo, methionine (0.1 mg/kg), vitamin C (2 g) and methionine plus vitamin C. Blood flow and platelet aggregation responses were unaffected by methionine loading. Substance P caused dose-dependent increases in plasma tissue plasminogen activator (t-PA) antigen (from 3.0+/-0.1 to 4.7+/-0.4 ng/ml; P
Original languageEnglish
Pages (from-to)127-35
Number of pages9
JournalClinical Science (London, England : 1979)
Volume100
Issue number2
Publication statusPublished - 2001

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    Labinjoh, C., Newby, D. E., Wilkinson, I. B., Megson, I. L., MacCallum, H., Melville, V., Boon, N. A., & Webb, D. J. (2001). Effects of acute methionine loading and vitamin C on endogenous fibrinolysis, endothelium-dependent vasomotion and platelet aggregation. Clinical Science (London, England : 1979), 100(2), 127-35.