Discovery and validation of urinary biomarkers for detection of renal cell carcinoma

Maria Frantzi, Jochen Metzger, Rosamonde E Banks, Holger Husi, Julie Klein, Mohammed Dakna, William Mullen, Jonathan J Cartledge, Joost P Schanstra, Korbinian Brand, Markus A Kuczyk, Harald Mischak, Antonia Vlahou, Dan Theodorescu, Axel S Merseburger

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Abstract

Clear cell renal cell carcinoma (RCC) has the highest incidence among the renal malignancies, often presenting non-specific or no symptoms at all. Moreover, with no diagnostic marker being available so far, almost 30% of the patients are diagnosed with metastatic disease and 30-40% of the patients initially diagnosed with localized tumor relapse. These facts introduce the clinical need of early diagnosis. This study is focused on the investigation of a marker model based on urinary peptides, as a tool for the detection of RCC in selected patients at risk. Upon evaluation of the marker model in an independent blinded set of 76 samples, 80% sensitivity and 87% specificity were reported. An additional dataset of 1077 samples was subsequently employed for further evaluation of the specificity of the classifier.
Original languageEnglish
Pages (from-to)44-58
Number of pages15
JournalJournal of Proteomics
Volume98C
DOIs
Publication statusPublished - 1 Feb 2014

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Frantzi, M., Metzger, J., Banks, R. E., Husi, H., Klein, J., Dakna, M., ... Merseburger, A. S. (2014). Discovery and validation of urinary biomarkers for detection of renal cell carcinoma. Journal of Proteomics, 98C, 44-58. https://doi.org/10.1016/j.jprot.2013.12.010