Direct vascular effects of protease-activated receptor type 1 agonism in vivo in humans

Ingibjörg J Gudmundsdóttir; Ian L Megson; Jillian S Kell; Christopher A Ludlam; Keith A A Fox; David J Webb; David E Newby

doi:10.1161/CIRCULATIONAHA.106.638478

Direct vascular effects of protease-activated receptor type 1 agonism in vivo in humans

Ingibjörg J Gudmundsdóttir, Ian L Megson, Jillian S Kell, Christopher A Ludlam, Keith A A Fox, David J Webb, David E Newby

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31 Citations (Scopus)

Abstract

Protease-activated receptor type 1 (PAR-1) has been proposed as the principal thrombin receptor in humans, although its actions in vivo have not been defined. The aim of the present study was to determine the direct vascular actions of PAR-1 agonism in humans.

Original language	English
Pages (from-to)	1625-32
Number of pages	8
Journal	Circulation
Volume	114
Issue number	15
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.106.638478
Publication status	Published - 2006

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title = "Direct vascular effects of protease-activated receptor type 1 agonism in vivo in humans",

abstract = "Protease-activated receptor type 1 (PAR-1) has been proposed as the principal thrombin receptor in humans, although its actions in vivo have not been defined. The aim of the present study was to determine the direct vascular actions of PAR-1 agonism in humans.",

author = "Gudmundsd{\'o}ttir, {Ingibj{\"o}rg J} and Megson, {Ian L} and Kell, {Jillian S} and Ludlam, {Christopher A} and Fox, {Keith A A} and Webb, {David J} and Newby, {David E}",

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T1 - Direct vascular effects of protease-activated receptor type 1 agonism in vivo in humans

AU - Gudmundsdóttir, Ingibjörg J

AU - Megson, Ian L

AU - Kell, Jillian S

AU - Ludlam, Christopher A

AU - Fox, Keith A A

AU - Webb, David J

AU - Newby, David E

PY - 2006

Y1 - 2006

N2 - Protease-activated receptor type 1 (PAR-1) has been proposed as the principal thrombin receptor in humans, although its actions in vivo have not been defined. The aim of the present study was to determine the direct vascular actions of PAR-1 agonism in humans.

AB - Protease-activated receptor type 1 (PAR-1) has been proposed as the principal thrombin receptor in humans, although its actions in vivo have not been defined. The aim of the present study was to determine the direct vascular actions of PAR-1 agonism in humans.

U2 - 10.1161/CIRCULATIONAHA.106.638478

DO - 10.1161/CIRCULATIONAHA.106.638478

M3 - Article

C2 - 17015787

SN - 1524-4539

VL - 114

SP - 1625

EP - 1632

JO - Circulation

JF - Circulation

IS - 15

ER -

Direct vascular effects of protease-activated receptor type 1 agonism in vivo in humans

Abstract

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