Direct vascular effects of protease-activated receptor type 1 agonism in vivo in humans

Ingibjörg J Gudmundsdóttir, Ian L Megson, Jillian S Kell, Christopher A Ludlam, Keith A A Fox, David J Webb, David E Newby

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27 Citations (Scopus)

Abstract

Protease-activated receptor type 1 (PAR-1) has been proposed as the principal thrombin receptor in humans, although its actions in vivo have not been defined. The aim of the present study was to determine the direct vascular actions of PAR-1 agonism in humans.
Original languageEnglish
Pages (from-to)1625-32
Number of pages8
JournalCirculation
Volume114
Issue number15
DOIs
Publication statusPublished - 2006

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    Gudmundsdóttir, I. J., Megson, I. L., Kell, J. S., Ludlam, C. A., Fox, K. A. A., Webb, D. J., & Newby, D. E. (2006). Direct vascular effects of protease-activated receptor type 1 agonism in vivo in humans. Circulation, 114(15), 1625-32. https://doi.org/10.1161/CIRCULATIONAHA.106.638478