Protease-activated receptor type 1 (PAR-1) has been proposed as the principal thrombin receptor in humans, although its actions in vivo have not been defined. The aim of the present study was to determine the direct vascular actions of PAR-1 agonism in humans.
Gudmundsdóttir, I. J., Megson, I. L., Kell, J. S., Ludlam, C. A., Fox, K. A. A., Webb, D. J., & Newby, D. E. (2006). Direct vascular effects of protease-activated receptor type 1 agonism in vivo in humans. Circulation, 114(15), 1625-32. https://doi.org/10.1161/CIRCULATIONAHA.106.638478