Determination of oligosaccharides in Pompe disease by electrospray ionization tandem mass spectrometry

Tina Rozaklis, Steven L Ramsay, Enzo Ranieri, John J Hopwood, Peter J Meikle, Phil Whitfield

Research output: Contribution to journalArticlepeer-review

61 Citations (Scopus)

Abstract

The development of therapies for lysosomal storage disorders has created a need for biochemical markers to monitor the efficacy of therapy and methods to quantify these markers in biologic samples. In Pompe disease, the concentration of a tetrasaccharide, consisting of four glucose residues, is reputedly increased in urine and plasma, but faster and more sensitive methods are required for the analysis of this, and other oligosaccharides, from biologic fluids.
Original languageEnglish
Pages (from-to)131-9
Number of pages9
JournalClinical Chemistry
Volume48
Issue number1
Publication statusPublished - Jan 2002

Keywords

  • Adolescent
  • Adult
  • Antipyrine
  • Child
  • Child, Preschool
  • Glycogen Storage Disease Type II
  • Humans
  • Indicators and Reagents
  • Infant
  • Infant, Newborn
  • Middle Aged
  • Oligosaccharides
  • Sensitivity and Specificity
  • Spectrometry, Mass, Electrospray Ionization

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