The development of therapies for lysosomal storage disorders has created a need for biochemical markers to monitor the efficacy of therapy and methods to quantify these markers in biologic samples. In Pompe disease, the concentration of a tetrasaccharide, consisting of four glucose residues, is reputedly increased in urine and plasma, but faster and more sensitive methods are required for the analysis of this, and other oligosaccharides, from biologic fluids.
|Number of pages||9|
|Publication status||Published - Jan 2002|
- Child, Preschool
- Glycogen Storage Disease Type II
- Indicators and Reagents
- Infant, Newborn
- Middle Aged
- Sensitivity and Specificity
- Spectrometry, Mass, Electrospray Ionization
Rozaklis, T., Ramsay, S. L., Ranieri, E., Hopwood, J. J., Meikle, P. J., & Whitfield, P. (2002). Determination of oligosaccharides in Pompe disease by electrospray ionization tandem mass spectrometry. Clinical Chemistry, 48(1), 131-9.