Degradative proteomics and disease mechanisms

Francesco Lanucara, Philip Brownridge, Iain S Young, Phil Whitfield, Mary K Doherty

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Protein degradation is a fundamental biological process, which is essential for the maintenance and regulation of normal cellular function. In humans and animals, proteins can be degraded by a number of mechanisms: the ubiquitin-proteasome system, autophagy and intracellular proteases. The advances in contemporary protein analysis means that proteomics is increasingly being used to explore these key pathways and as a means of monitoring protein degradation. The dysfunction of protein degradative pathways has been associated with the development of a number of important diseases including cancer, muscle wasting disorders and neurodegenerative diseases. This review will focus on the role of proteomics to study cellular degradative processes and how these strategies are being applied to understand the molecular basis of diseases arising from disturbances in protein degradation.
Original languageEnglish
Pages (from-to)133-42
Number of pages10
JournalProteomics. Clinical Applications
Volume4
Issue number2
DOIs
Publication statusPublished - 2010

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