Abstract
The present study detected three single nucleotide polymorphisms (SNPs), BanISNP at the PLA2G4A locus, rs1648833 at the PLA2G4B locus, and rs1549637 at the PLA2G4C locus, to investigate a genetic association between the cytosolic PLA2 (cPLA2) genes and schizophrenia. A total of 240 Chinese parent-offspring trios of Han descent were recruited for the genetic analysis. The transmission disequilibrium test (TDT) showed allelic association for rs1549637 (chi(2) = 5.68, uncorrected P = 0.017), but not for BanISNP and rs1648833. The conditioning on genotype (COG) test revealed a disease association for the BanISNP-rs1648833 combination (chi(2) = 12.54, df = 3, P = 0.0057) and for the BanISNP-rs1549637 combination (chi(2) = 9.72, df = 2, P = 0.021), but the conditioning on allele (COA) test did not show such an association for the above two combinations. Neither the COA test nor the COG showed a disease association for the rs1648833-rs1549637 combination. In the combination of all three SNPs, the COG test, but not the COA test, showed a strong association (chi(2) = 22.93, df = 6, P = 0.0008). These findings suggest that these three cPLA2 genes may all be involved in contributing to the etiology of schizophrenia although their effect size appears to be relatively small.
Original language | English |
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Pages (from-to) | 56-8 |
Number of pages | 3 |
Journal | American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics |
Volume | 137B |
Issue number | 1 |
DOIs | |
Publication status | Published - 5 Aug 2005 |
Keywords
- Adult
- Alleles
- Chi-Square Distribution
- Cytosol
- Female
- Gene Frequency
- Genotype
- Humans
- Isoenzymes
- Linkage Disequilibrium
- Male
- Nuclear Family
- Phospholipases A
- Phospholipases A2
- Polymorphism, Single Nucleotide
- Schizophrenia