Clearance of dying cells and autoimmunity

Sylwia Michlewska; Aisleen McColl; Adriano G Rossi; Ian L Megson; Ian Dransfield

doi:10.1080/08916930701357208

Clearance of dying cells and autoimmunity

Sylwia Michlewska, Aisleen McColl, Adriano G Rossi, Ian L Megson, Ian Dransfield

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Phagocytic clearance of apoptotic cells is an important physiologic homeostatic mechanism that is associated with non-inflammatory or anti-inflammatory sequalae. Disruption of the process of apoptotic cell clearance may contribute to development of a number of inflammatory and autoimmune diseases. In this review, we summarize the molecular pathways that have been suggested to account for phagocytic clearance of apoptotic cells. We discuss potential mechanisms for regulation of phagocytosis and the implications for development of autoimmunity.

Original language	English
Pages (from-to)	267-73
Number of pages	7
Journal	Autoimmunity
Volume	40
Issue number	4
DOIs	https://doi.org/10.1080/08916930701357208
Publication status	Published - 2007

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1080/08916930701357208

Handle.net

Persistent link

Cite this

@article{1edb8e54b7f9495a969b1065b6075d33,

title = "Clearance of dying cells and autoimmunity",

abstract = "Phagocytic clearance of apoptotic cells is an important physiologic homeostatic mechanism that is associated with non-inflammatory or anti-inflammatory sequalae. Disruption of the process of apoptotic cell clearance may contribute to development of a number of inflammatory and autoimmune diseases. In this review, we summarize the molecular pathways that have been suggested to account for phagocytic clearance of apoptotic cells. We discuss potential mechanisms for regulation of phagocytosis and the implications for development of autoimmunity.",

author = "Sylwia Michlewska and Aisleen McColl and Rossi, {Adriano G} and Megson, {Ian L} and Ian Dransfield",

year = "2007",

doi = "10.1080/08916930701357208",

language = "English",

volume = "40",

pages = "267--73",

journal = "Autoimmunity",

issn = "0891-6934",

publisher = "Informa Healthcare",

number = "4",

}

TY - JOUR

T1 - Clearance of dying cells and autoimmunity

AU - Michlewska, Sylwia

AU - McColl, Aisleen

AU - Rossi, Adriano G

AU - Megson, Ian L

AU - Dransfield, Ian

PY - 2007

Y1 - 2007

N2 - Phagocytic clearance of apoptotic cells is an important physiologic homeostatic mechanism that is associated with non-inflammatory or anti-inflammatory sequalae. Disruption of the process of apoptotic cell clearance may contribute to development of a number of inflammatory and autoimmune diseases. In this review, we summarize the molecular pathways that have been suggested to account for phagocytic clearance of apoptotic cells. We discuss potential mechanisms for regulation of phagocytosis and the implications for development of autoimmunity.

AB - Phagocytic clearance of apoptotic cells is an important physiologic homeostatic mechanism that is associated with non-inflammatory or anti-inflammatory sequalae. Disruption of the process of apoptotic cell clearance may contribute to development of a number of inflammatory and autoimmune diseases. In this review, we summarize the molecular pathways that have been suggested to account for phagocytic clearance of apoptotic cells. We discuss potential mechanisms for regulation of phagocytosis and the implications for development of autoimmunity.

U2 - 10.1080/08916930701357208

DO - 10.1080/08916930701357208

M3 - Article

C2 - 17516208

SN - 0891-6934

VL - 40

SP - 267

EP - 273

JO - Autoimmunity

JF - Autoimmunity

IS - 4

ER -

Clearance of dying cells and autoimmunity

Abstract

UN SDGs

Access to Document

Handle.net

Fingerprint

Cite this