Clearance of dying cells and autoimmunity

Sylwia Michlewska, Aisleen McColl, Adriano G Rossi, Ian L Megson, Ian Dransfield

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36 Citations (Scopus)

Abstract

Phagocytic clearance of apoptotic cells is an important physiologic homeostatic mechanism that is associated with non-inflammatory or anti-inflammatory sequalae. Disruption of the process of apoptotic cell clearance may contribute to development of a number of inflammatory and autoimmune diseases. In this review, we summarize the molecular pathways that have been suggested to account for phagocytic clearance of apoptotic cells. We discuss potential mechanisms for regulation of phagocytosis and the implications for development of autoimmunity.
Original languageEnglish
Pages (from-to)267-73
Number of pages7
JournalAutoimmunity
Volume40
Issue number4
DOIs
Publication statusPublished - 2007

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Michlewska, S., McColl, A., Rossi, A. G., Megson, I. L., & Dransfield, I. (2007). Clearance of dying cells and autoimmunity. Autoimmunity, 40(4), 267-73. https://doi.org/10.1080/08916930701357208