Circulating autoantibody to FOXP3 may be a potential biomarker for esophageal squamous cell carcinoma.

Leiguang Ye, Songlei Guan, Cong Zhang, Kuang-Hui Lee, Shilong Sun, Jun Wei, Baogang Liu

Research output: Contribution to journalArticle

21 Citations (Scopus)


The present study was undertaken to develop a relatively quantitative enzyme-linked immunosorbent assay (ELISA) in-house using human leukocyte antigen class II-restricted epitopes in order to test circulating autoantibodies to human forkhead/winged helix transcription factor (FOXP3) as a biomarker for esophageal cancer. A total of 97 patients with esophageal squamous cell carcinoma (ESCC) and 227 healthy subjects were recruited for this study, and their plasma samples were collected for antibody analysis with the ELISA approach. Student's t test showed that the anti-FOXP3 IgG antibody levels were significantly higher in the patient group than the control group (t=6.23, P95 % specificity was 22.7 % for the IgG assay with an inter-assay deviation of 13.35 %. This work suggests that circulating IgG autoantibody to FOXP3 may be a potential biomarker for early diagnosis of esophageal cancer.
Original languageEnglish
Pages (from-to)1873-1877
Number of pages5
JournalTumour Biology : The Journal of the International Society for Oncodevelopmental Biology and Medicine
Issue number3
Publication statusPublished - Jun 2013



  • Area Under Curve
  • Autoantibodies
  • Carcinoma, Squamous Cell
  • Case-Control Studies
  • Enzyme-Linked Immunosorbent Assay
  • Esophageal Neoplasms
  • Female
  • Follow-Up Studies
  • Forkhead Transcription Factors
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Neoplastic Cells, Circulating
  • Prognosis
  • Survival Rate
  • Tumor Markers, Biological

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