Changes in fatty acid profiles in testis and spermatozoa of red deer exposed to metal pollution

Pilar Castellanos, Manuel M Reglero, Mark A Taggart, Rafael Mateo

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18 Citations (Scopus)

Abstract

Lowered sperm quality associated with reduced superoxide dismutase activity in testis and spermatozoa has been observed in red deer from a mined area in South-central Spain. Here we present fatty acid profiles for testis and spermatozoa of deer from this mined area (n=29) and a control area (n=33). Despite elevated Pb in liver and bone of red deer from this area, concentrations in testis and sperm were not significantly higher than in control areas; however, Cu in testis was lower in mined areas. Testis from mined areas also contained higher percentages of linoleic acid (18:2n-6) and dihomo-gamma-linolenic acid (20:3n-6), but lower arachidonic acid (20:4n-6). The percentage of 20:4n-6 was also lower in spermatozoa of deer from the mined area. Copper levels in testis correlated positively with the percentage of 20:4n-6. The imbalance in Cu homeostasis caused by metal pollution may have caused the observed effects on deer sperm.
Original languageEnglish
Pages (from-to)346-52
Number of pages7
JournalReproductive Toxicology (Elmsford, N.Y.)
Volume29
Issue number3
DOIs
Publication statusPublished - 2010

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