Abstract
Ingestion of the poisonous weed ragwort (Senecio jacobea) by horses leads to irreversible liver damage. The principal toxins of ragwort are the pyrrolizidine alkaloids that are rapidly metabolised to highly reactive and cytotoxic pyrroles, which can escape into the circulation and bind to proteins. In this study a non-invasive in vitro model system has been developed to investigate whether pyrrole toxins induce specific modifications of equine blood proteins that are detectable by proteomic methods.
Original language | English |
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Pages (from-to) | 30 |
Journal | BMC Veterinary Research |
Volume | 4 |
DOIs | |
Publication status | Published - 2008 |
Keywords
- Animals
- Biological Markers
- Blood Proteins
- Blotting, Western
- Fibrinogen
- Hemoglobins
- Horse Diseases
- Horses
- Plant Poisoning
- Plants, Toxic
- Proteomics
- Pyrroles
- Pyrrolizidine Alkaloids
- Senecio
- Time Factors