Biomarkers for ragwort poisoning in horses: identification of protein targets

Rowan E Moore, Derek Knottenbelt, Jacqueline B Matthews, Robert J Beynon, Phil Whitfield

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Ingestion of the poisonous weed ragwort (Senecio jacobea) by horses leads to irreversible liver damage. The principal toxins of ragwort are the pyrrolizidine alkaloids that are rapidly metabolised to highly reactive and cytotoxic pyrroles, which can escape into the circulation and bind to proteins. In this study a non-invasive in vitro model system has been developed to investigate whether pyrrole toxins induce specific modifications of equine blood proteins that are detectable by proteomic methods.
Original languageEnglish
Pages (from-to)30
JournalBMC Veterinary Research
Volume4
DOIs
Publication statusPublished - 2008

Keywords

  • Animals
  • Biological Markers
  • Blood Proteins
  • Blotting, Western
  • Fibrinogen
  • Hemoglobins
  • Horse Diseases
  • Horses
  • Plant Poisoning
  • Plants, Toxic
  • Proteomics
  • Pyrroles
  • Pyrrolizidine Alkaloids
  • Senecio
  • Time Factors

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