B1 kinin receptor does not contribute to vascular tone or tissue plasminogen activator release in the peripheral circulation of patients with heart failure

Nicholas L M Cruden, George H Tse, Keith A A Fox, Christopher A Ludlam, Ian Megson, David E Newby

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Vascular expression of the B1 kinin receptor is markedly upregulated with left ventricular dysfunction and angiotensin-converting enzyme (ACE) inhibition, but its function remains unclear. Inhibitors of ACE potentiate bradykinin-mediated B2 receptor-dependent vasodilatation and tissue plasminogen activator (tissue-type plasminogen activator [t-PA]) release. We investigated the contribution of the B1 receptor to the maintenance of vascular tone and t-PA release in patients with heart failure.
Original languageEnglish
Pages (from-to)772-7
Number of pages6
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume25
Issue number4
DOIs
Publication statusPublished - 2005

Fingerprint Dive into the research topics of 'B1 kinin receptor does not contribute to vascular tone or tissue plasminogen activator release in the peripheral circulation of patients with heart failure'. Together they form a unique fingerprint.

  • Cite this