B1 kinin receptor does not contribute to vascular tone or tissue plasminogen activator release in the peripheral circulation of patients with heart failure

Nicholas L M Cruden; George H Tse; Keith A A Fox; Christopher A Ludlam; Ian Megson; David E Newby

doi:10.1161/01.ATV.0000157157.78822.25

B1 kinin receptor does not contribute to vascular tone or tissue plasminogen activator release in the peripheral circulation of patients with heart failure

Nicholas L M Cruden, George H Tse, Keith A A Fox, Christopher A Ludlam, Ian Megson, David E Newby

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Vascular expression of the B1 kinin receptor is markedly upregulated with left ventricular dysfunction and angiotensin-converting enzyme (ACE) inhibition, but its function remains unclear. Inhibitors of ACE potentiate bradykinin-mediated B2 receptor-dependent vasodilatation and tissue plasminogen activator (tissue-type plasminogen activator [t-PA]) release. We investigated the contribution of the B1 receptor to the maintenance of vascular tone and t-PA release in patients with heart failure.

Original language	English
Pages (from-to)	772-7
Number of pages	6
Journal	Arteriosclerosis, Thrombosis, and Vascular Biology
Volume	25
Issue number	4
DOIs	https://doi.org/10.1161/01.ATV.0000157157.78822.25
Publication status	Published - 2005

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10.1161/01.ATV.0000157157.78822.25

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title = "B1 kinin receptor does not contribute to vascular tone or tissue plasminogen activator release in the peripheral circulation of patients with heart failure",

abstract = "Vascular expression of the B1 kinin receptor is markedly upregulated with left ventricular dysfunction and angiotensin-converting enzyme (ACE) inhibition, but its function remains unclear. Inhibitors of ACE potentiate bradykinin-mediated B2 receptor-dependent vasodilatation and tissue plasminogen activator (tissue-type plasminogen activator [t-PA]) release. We investigated the contribution of the B1 receptor to the maintenance of vascular tone and t-PA release in patients with heart failure.",

author = "Cruden, {Nicholas L M} and Tse, {George H} and Fox, {Keith A A} and Ludlam, {Christopher A} and Ian Megson and Newby, {David E}",

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language = "English",

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pages = "772--7",

journal = "Arteriosclerosis, Thrombosis, and Vascular Biology",

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publisher = "Lippincott Williams and Wilkins",

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B1 kinin receptor does not contribute to vascular tone or tissue plasminogen activator release in the peripheral circulation of patients with heart failure. / Cruden, Nicholas L M; Tse, George H; Fox, Keith A A et al.
In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 25, No. 4, 2005, p. 772-7.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - B1 kinin receptor does not contribute to vascular tone or tissue plasminogen activator release in the peripheral circulation of patients with heart failure

AU - Cruden, Nicholas L M

AU - Tse, George H

AU - Fox, Keith A A

AU - Ludlam, Christopher A

AU - Megson, Ian

AU - Newby, David E

PY - 2005

Y1 - 2005

N2 - Vascular expression of the B1 kinin receptor is markedly upregulated with left ventricular dysfunction and angiotensin-converting enzyme (ACE) inhibition, but its function remains unclear. Inhibitors of ACE potentiate bradykinin-mediated B2 receptor-dependent vasodilatation and tissue plasminogen activator (tissue-type plasminogen activator [t-PA]) release. We investigated the contribution of the B1 receptor to the maintenance of vascular tone and t-PA release in patients with heart failure.

AB - Vascular expression of the B1 kinin receptor is markedly upregulated with left ventricular dysfunction and angiotensin-converting enzyme (ACE) inhibition, but its function remains unclear. Inhibitors of ACE potentiate bradykinin-mediated B2 receptor-dependent vasodilatation and tissue plasminogen activator (tissue-type plasminogen activator [t-PA]) release. We investigated the contribution of the B1 receptor to the maintenance of vascular tone and t-PA release in patients with heart failure.

U2 - 10.1161/01.ATV.0000157157.78822.25

DO - 10.1161/01.ATV.0000157157.78822.25

M3 - Article

C2 - 15681300

SN - 1524-4636

VL - 25

SP - 772

EP - 777

JO - Arteriosclerosis, Thrombosis, and Vascular Biology

JF - Arteriosclerosis, Thrombosis, and Vascular Biology

IS - 4

ER -

B1 kinin receptor does not contribute to vascular tone or tissue plasminogen activator release in the peripheral circulation of patients with heart failure

Abstract

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