Vascular expression of the B1 kinin receptor is markedly upregulated with left ventricular dysfunction and angiotensin-converting enzyme (ACE) inhibition, but its function remains unclear. Inhibitors of ACE potentiate bradykinin-mediated B2 receptor-dependent vasodilatation and tissue plasminogen activator (tissue-type plasminogen activator [t-PA]) release. We investigated the contribution of the B1 receptor to the maintenance of vascular tone and t-PA release in patients with heart failure.
|Number of pages||6|
|Journal||Arteriosclerosis, Thrombosis, and Vascular Biology|
|Publication status||Published - 2005|
Cruden, N. L. M., Tse, G. H., Fox, K. A. A., Ludlam, C. A., Megson, I., & Newby, D. E. (2005). B1 kinin receptor does not contribute to vascular tone or tissue plasminogen activator release in the peripheral circulation of patients with heart failure. Arteriosclerosis, Thrombosis, and Vascular Biology, 25(4), 772-7. https://doi.org/10.1161/01.ATV.0000157157.78822.25