B1 kinin receptor does not contribute to vascular tone or tissue plasminogen activator release in the peripheral circulation of patients with heart failure

Nicholas L M Cruden, George H Tse, Keith A A Fox, Christopher A Ludlam, Ian Megson, David E Newby

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Vascular expression of the B1 kinin receptor is markedly upregulated with left ventricular dysfunction and angiotensin-converting enzyme (ACE) inhibition, but its function remains unclear. Inhibitors of ACE potentiate bradykinin-mediated B2 receptor-dependent vasodilatation and tissue plasminogen activator (tissue-type plasminogen activator [t-PA]) release. We investigated the contribution of the B1 receptor to the maintenance of vascular tone and t-PA release in patients with heart failure.
Original languageEnglish
Pages (from-to)772-7
Number of pages6
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Issue number4
Publication statusPublished - 2005


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