Attack of the Subclones: Accurate Detection of Mutational Heterogeneity in Bulk DNA from Tumors

Chloe B. Rodgers, Natasa Broit, Peter A. Johansson, Antonia L. Pritchard

Research output: Contribution to journalComment/debate

Abstract

Tumors are often polyclonal and are therefore heterogenous in their genomic and molecular profiles, which contributes to drug resistance and treatment failure. The methods used to detect these heterogenous differences in tumor samples are critical, but findings have been hindered by methodological inability to detect low-frequency subclones in bulk DNA. Chang et al. (2020) have addressed some of these methodological issues.

Original languageEnglish
Pages (from-to)1501-1503
Number of pages3
JournalJournal of Investigative Dermatology
Volume140
Issue number8
Early online date21 Jul 2020
DOIs
Publication statusPublished - 1 Aug 2020

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