TY - JOUR
T1 - Attack of the Subclones
T2 - Accurate Detection of Mutational Heterogeneity in Bulk DNA from Tumors
AU - Rodgers, Chloe B.
AU - Broit, Natasa
AU - Johansson, Peter A.
AU - Pritchard, Antonia L.
N1 - © 2020 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.
PY - 2020/8/1
Y1 - 2020/8/1
N2 - Tumors are often polyclonal and are therefore heterogenous in their genomic and molecular profiles, which contributes to drug resistance and treatment failure. The methods used to detect these heterogenous differences in tumor samples are critical, but findings have been hindered by methodological inability to detect low-frequency subclones in bulk DNA. Chang et al. (2020) have addressed some of these methodological issues.
AB - Tumors are often polyclonal and are therefore heterogenous in their genomic and molecular profiles, which contributes to drug resistance and treatment failure. The methods used to detect these heterogenous differences in tumor samples are critical, but findings have been hindered by methodological inability to detect low-frequency subclones in bulk DNA. Chang et al. (2020) have addressed some of these methodological issues.
UR - http://www.scopus.com/inward/record.url?scp=85088273504&partnerID=8YFLogxK
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U2 - 10.1016/j.jid.2020.02.017
DO - 10.1016/j.jid.2020.02.017
M3 - Comment/debate
C2 - 32709275
AN - SCOPUS:85088273504
SN - 0022-202X
VL - 140
SP - 1501
EP - 1503
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 8
ER -