Association study of the human FZD3 locus with schizophrenia

Jianzhong Yang; Tianmei Si; Yansu Ling; Yan Ruan; Yonghua Han; Xiling Wang; Hongyan Zhang; Qingmei Kong; Xueni Li; Cui Liu; Darong Zhang; Mo Zhou; Yaqin Yu; Shuzeng Liu; Liang Shu; Dalong Ma; Jun Wei; Dai Zhang

Association study of the human FZD3 locus with schizophrenia

Jianzhong Yang, Tianmei Si, Yansu Ling, Yan Ruan, Yonghua Han, Xiling Wang, Hongyan Zhang, Qingmei Kong, Xueni Li, Cui Liu, Darong Zhang, Mo Zhou, Yaqin Yu, Shuzeng Liu, Liang Shu, Dalong Ma, Jun Wei, Dai Zhang

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

Abstract

The FZD3 protein is a transmembrane receptor for secreted Wnt glycoproteins involved in the Wnt signal transduction cascades. The alteration of Wnt signal transduction cascades has been thought to be involved in producing the cytoarchitectural defects observed in schizophrenia. Because the human FZD3 gene is mapped to chromosome 8p21, which is a potential region containing a gene for schizophrenia, it may play a role in conferring susceptibility to the disease. This study was conducted with the detection of three single nucleotide polymorphisms (SNPs) located within the FZD3 locus by using the polymerase chain reaction-based restriction fragment length polymorphism (RFLP) analysis among 246 schizophrenic family trios of Chinese Han descent.The transmission disequilibrium test (TDT) demonstrated that the three SNPs all showed a preferential transmission with a p value ranging from.0003-.000007. The global chi-squared test for haplotype transmission also showed a strong association (chi(2) = 48.84, df = 7, p

Original language	English
Pages (from-to)	1298-301
Number of pages	4
Journal	Biological Psychiatry
Volume	54
Issue number	11
Publication status	Published - 1 Dec 2003

Keywords

Chromosomes, Human, Pair 8
Female
Frizzled Receptors
Genetic Predisposition to Disease
Genotype
Humans
Male
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide
Receptors, G-Protein-Coupled
Schizophrenia

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title = "Association study of the human FZD3 locus with schizophrenia",

abstract = "The FZD3 protein is a transmembrane receptor for secreted Wnt glycoproteins involved in the Wnt signal transduction cascades. The alteration of Wnt signal transduction cascades has been thought to be involved in producing the cytoarchitectural defects observed in schizophrenia. Because the human FZD3 gene is mapped to chromosome 8p21, which is a potential region containing a gene for schizophrenia, it may play a role in conferring susceptibility to the disease. This study was conducted with the detection of three single nucleotide polymorphisms (SNPs) located within the FZD3 locus by using the polymerase chain reaction-based restriction fragment length polymorphism (RFLP) analysis among 246 schizophrenic family trios of Chinese Han descent.The transmission disequilibrium test (TDT) demonstrated that the three SNPs all showed a preferential transmission with a p value ranging from.0003-.000007. The global chi-squared test for haplotype transmission also showed a strong association (chi(2) = 48.84, df = 7, p ",

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author = "Jianzhong Yang and Tianmei Si and Yansu Ling and Yan Ruan and Yonghua Han and Xiling Wang and Hongyan Zhang and Qingmei Kong and Xueni Li and Cui Liu and Darong Zhang and Mo Zhou and Yaqin Yu and Shuzeng Liu and Liang Shu and Dalong Ma and Jun Wei and Dai Zhang",

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pages = "1298--301",

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T1 - Association study of the human FZD3 locus with schizophrenia

AU - Yang, Jianzhong

AU - Si, Tianmei

AU - Ling, Yansu

AU - Ruan, Yan

AU - Han, Yonghua

AU - Wang, Xiling

AU - Zhang, Hongyan

AU - Kong, Qingmei

AU - Li, Xueni

AU - Liu, Cui

AU - Zhang, Darong

AU - Zhou, Mo

AU - Yu, Yaqin

AU - Liu, Shuzeng

AU - Shu, Liang

AU - Ma, Dalong

AU - Wei, Jun

AU - Zhang, Dai

PY - 2003/12/1

Y1 - 2003/12/1

N2 - The FZD3 protein is a transmembrane receptor for secreted Wnt glycoproteins involved in the Wnt signal transduction cascades. The alteration of Wnt signal transduction cascades has been thought to be involved in producing the cytoarchitectural defects observed in schizophrenia. Because the human FZD3 gene is mapped to chromosome 8p21, which is a potential region containing a gene for schizophrenia, it may play a role in conferring susceptibility to the disease. This study was conducted with the detection of three single nucleotide polymorphisms (SNPs) located within the FZD3 locus by using the polymerase chain reaction-based restriction fragment length polymorphism (RFLP) analysis among 246 schizophrenic family trios of Chinese Han descent.The transmission disequilibrium test (TDT) demonstrated that the three SNPs all showed a preferential transmission with a p value ranging from.0003-.000007. The global chi-squared test for haplotype transmission also showed a strong association (chi(2) = 48.84, df = 7, p

AB - The FZD3 protein is a transmembrane receptor for secreted Wnt glycoproteins involved in the Wnt signal transduction cascades. The alteration of Wnt signal transduction cascades has been thought to be involved in producing the cytoarchitectural defects observed in schizophrenia. Because the human FZD3 gene is mapped to chromosome 8p21, which is a potential region containing a gene for schizophrenia, it may play a role in conferring susceptibility to the disease. This study was conducted with the detection of three single nucleotide polymorphisms (SNPs) located within the FZD3 locus by using the polymerase chain reaction-based restriction fragment length polymorphism (RFLP) analysis among 246 schizophrenic family trios of Chinese Han descent.The transmission disequilibrium test (TDT) demonstrated that the three SNPs all showed a preferential transmission with a p value ranging from.0003-.000007. The global chi-squared test for haplotype transmission also showed a strong association (chi(2) = 48.84, df = 7, p

KW - Chromosomes, Human, Pair 8

KW - Female

KW - Frizzled Receptors

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Humans

KW - Male

KW - Polymerase Chain Reaction

KW - Polymorphism, Restriction Fragment Length

KW - Polymorphism, Single Nucleotide

KW - Receptors, G-Protein-Coupled

KW - Schizophrenia

M3 - Article

C2 - 14643098

SN - 0006-3223

VL - 54

SP - 1298

EP - 1301

JO - Biological Psychiatry

JF - Biological Psychiatry

IS - 11

ER -

Association study of the human FZD3 locus with schizophrenia

Abstract

Keywords

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