Association study of the human FZD3 locus with schizophrenia

Jianzhong Yang, Tianmei Si, Yansu Ling, Yan Ruan, Yonghua Han, Xiling Wang, Hongyan Zhang, Qingmei Kong, Xueni Li, Cui Liu, Darong Zhang, Mo Zhou, Yaqin Yu, Shuzeng Liu, Liang Shu, Dalong Ma, Jun Wei, Dai Zhang

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57 Citations (Scopus)

Abstract

The FZD3 protein is a transmembrane receptor for secreted Wnt glycoproteins involved in the Wnt signal transduction cascades. The alteration of Wnt signal transduction cascades has been thought to be involved in producing the cytoarchitectural defects observed in schizophrenia. Because the human FZD3 gene is mapped to chromosome 8p21, which is a potential region containing a gene for schizophrenia, it may play a role in conferring susceptibility to the disease. This study was conducted with the detection of three single nucleotide polymorphisms (SNPs) located within the FZD3 locus by using the polymerase chain reaction-based restriction fragment length polymorphism (RFLP) analysis among 246 schizophrenic family trios of Chinese Han descent.The transmission disequilibrium test (TDT) demonstrated that the three SNPs all showed a preferential transmission with a p value ranging from.0003-.000007. The global chi-squared test for haplotype transmission also showed a strong association (chi(2) = 48.84, df = 7, p
Original languageEnglish
Pages (from-to)1298-301
Number of pages4
JournalBiological Psychiatry
Volume54
Issue number11
Publication statusPublished - 1 Dec 2003

Keywords

  • Chromosomes, Human, Pair 8
  • Female
  • Frizzled Receptors
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Male
  • Polymerase Chain Reaction
  • Polymorphism, Restriction Fragment Length
  • Polymorphism, Single Nucleotide
  • Receptors, G-Protein-Coupled
  • Schizophrenia

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  • Cite this

    Yang, J., Si, T., Ling, Y., Ruan, Y., Han, Y., Wang, X., Zhang, H., Kong, Q., Li, X., Liu, C., Zhang, D., Zhou, M., Yu, Y., Liu, S., Shu, L., Ma, D., Wei, J., & Zhang, D. (2003). Association study of the human FZD3 locus with schizophrenia. Biological Psychiatry, 54(11), 1298-301.