Association study between interleukin-1beta gene (IL-1beta) and schizophrenia

Jianzhong Yang, Tianmei Si, Yansu Ling, Yan Ruan, Yonghua Han, Xiling Wang, Mo Zhou, Darong Zhang, Hongyan Zhang, Qingmei Kong, Cui Liu, Xueni Li, Yaqin Yu, Shuzeng Liu, Liang Shu, Dalong Ma, Jun Wei, Dai Zhang

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Abstract

An increasing amount of evidence suggests that the pathophysiology of schizophrenia is associated with the abnormal immune system, and cytokines may be important in schizophrenia. Among these cytokines, interleukin-1beta may play a role in the pathogenesis of the disease. In the present study, we investigated the genetic association between a TaqI polymorphism in interleukin-1beta gene (IL-1beta) and schizophrenia by restriction fragment length polymorphism (RFLP) analysis among 132 Chinese families of Han descent. The transmission disequilibrium test (TDT) did not demonstrate an allelic association with schizophrenia. Our results suggested that the TaqI polymorphism in IL-1beta gene might not confer increased susceptibility for schizophrenia.
Original languageEnglish
Pages (from-to)3017-21
Number of pages5
JournalHistory and Philosophy of the Life Sciences
Volume72
Issue number26
Publication statusPublished - 16 May 2003

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Keywords

  • Adolescent
  • Adult
  • Alleles
  • China
  • Female
  • Genotype
  • Humans
  • Interleukin-1
  • Male
  • Polymorphism, Restriction Fragment Length
  • Schizophrenia

Cite this

Yang, J., Si, T., Ling, Y., Ruan, Y., Han, Y., Wang, X., ... Zhang, D. (2003). Association study between interleukin-1beta gene (IL-1beta) and schizophrenia. History and Philosophy of the Life Sciences, 72(26), 3017-21.