Association study between interleukin-1beta gene (IL-1beta) and schizophrenia

Jianzhong Yang; Tianmei Si; Yansu Ling; Yan Ruan; Yonghua Han; Xiling Wang; Mo Zhou; Darong Zhang; Hongyan Zhang; Qingmei Kong; Cui Liu; Xueni Li; Yaqin Yu; Shuzeng Liu; Liang Shu; Dalong Ma; Jun Wei; Dai Zhang

Association study between interleukin-1beta gene (IL-1beta) and schizophrenia

Jianzhong Yang, Tianmei Si, Yansu Ling, Yan Ruan, Yonghua Han, Xiling Wang, Mo Zhou, Darong Zhang, Hongyan Zhang, Qingmei Kong, Cui Liu, Xueni Li, Yaqin Yu, Shuzeng Liu, Liang Shu, Dalong Ma, Jun Wei, Dai Zhang

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

An increasing amount of evidence suggests that the pathophysiology of schizophrenia is associated with the abnormal immune system, and cytokines may be important in schizophrenia. Among these cytokines, interleukin-1beta may play a role in the pathogenesis of the disease. In the present study, we investigated the genetic association between a TaqI polymorphism in interleukin-1beta gene (IL-1beta) and schizophrenia by restriction fragment length polymorphism (RFLP) analysis among 132 Chinese families of Han descent. The transmission disequilibrium test (TDT) did not demonstrate an allelic association with schizophrenia. Our results suggested that the TaqI polymorphism in IL-1beta gene might not confer increased susceptibility for schizophrenia.

Original language	English
Pages (from-to)	3017-21
Number of pages	5
Journal	History and Philosophy of the Life Sciences
Volume	72
Issue number	26
Publication status	Published - 16 May 2003

Keywords

Adolescent
Adult
Alleles
China
Female
Genotype
Humans
Interleukin-1
Male
Polymorphism, Restriction Fragment Length
Schizophrenia

Cite this

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title = "Association study between interleukin-1beta gene (IL-1beta) and schizophrenia",

abstract = "An increasing amount of evidence suggests that the pathophysiology of schizophrenia is associated with the abnormal immune system, and cytokines may be important in schizophrenia. Among these cytokines, interleukin-1beta may play a role in the pathogenesis of the disease. In the present study, we investigated the genetic association between a TaqI polymorphism in interleukin-1beta gene (IL-1beta) and schizophrenia by restriction fragment length polymorphism (RFLP) analysis among 132 Chinese families of Han descent. The transmission disequilibrium test (TDT) did not demonstrate an allelic association with schizophrenia. Our results suggested that the TaqI polymorphism in IL-1beta gene might not confer increased susceptibility for schizophrenia.",

keywords = "Adolescent, Adult, Alleles, China, Female, Genotype, Humans, Interleukin-1, Male, Polymorphism, Restriction Fragment Length, Schizophrenia",

author = "Jianzhong Yang and Tianmei Si and Yansu Ling and Yan Ruan and Yonghua Han and Xiling Wang and Mo Zhou and Darong Zhang and Hongyan Zhang and Qingmei Kong and Cui Liu and Xueni Li and Yaqin Yu and Shuzeng Liu and Liang Shu and Dalong Ma and Jun Wei and Dai Zhang",

year = "2003",

month = may,

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language = "English",

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journal = "History and Philosophy of the Life Sciences",

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TY - JOUR

T1 - Association study between interleukin-1beta gene (IL-1beta) and schizophrenia

AU - Yang, Jianzhong

AU - Si, Tianmei

AU - Ling, Yansu

AU - Ruan, Yan

AU - Han, Yonghua

AU - Wang, Xiling

AU - Zhou, Mo

AU - Zhang, Darong

AU - Zhang, Hongyan

AU - Kong, Qingmei

AU - Liu, Cui

AU - Li, Xueni

AU - Yu, Yaqin

AU - Liu, Shuzeng

AU - Shu, Liang

AU - Ma, Dalong

AU - Wei, Jun

AU - Zhang, Dai

PY - 2003/5/16

Y1 - 2003/5/16

N2 - An increasing amount of evidence suggests that the pathophysiology of schizophrenia is associated with the abnormal immune system, and cytokines may be important in schizophrenia. Among these cytokines, interleukin-1beta may play a role in the pathogenesis of the disease. In the present study, we investigated the genetic association between a TaqI polymorphism in interleukin-1beta gene (IL-1beta) and schizophrenia by restriction fragment length polymorphism (RFLP) analysis among 132 Chinese families of Han descent. The transmission disequilibrium test (TDT) did not demonstrate an allelic association with schizophrenia. Our results suggested that the TaqI polymorphism in IL-1beta gene might not confer increased susceptibility for schizophrenia.

AB - An increasing amount of evidence suggests that the pathophysiology of schizophrenia is associated with the abnormal immune system, and cytokines may be important in schizophrenia. Among these cytokines, interleukin-1beta may play a role in the pathogenesis of the disease. In the present study, we investigated the genetic association between a TaqI polymorphism in interleukin-1beta gene (IL-1beta) and schizophrenia by restriction fragment length polymorphism (RFLP) analysis among 132 Chinese families of Han descent. The transmission disequilibrium test (TDT) did not demonstrate an allelic association with schizophrenia. Our results suggested that the TaqI polymorphism in IL-1beta gene might not confer increased susceptibility for schizophrenia.

KW - Adolescent

KW - Adult

KW - Alleles

KW - China

KW - Female

KW - Genotype

KW - Humans

KW - Interleukin-1

KW - Male

KW - Polymorphism, Restriction Fragment Length

KW - Schizophrenia

M3 - Article

C2 - 12706488

SN - 0024-3205

VL - 72

SP - 3017

EP - 3021

JO - History and Philosophy of the Life Sciences

JF - History and Philosophy of the Life Sciences

IS - 26

ER -

Association study between interleukin-1beta gene (IL-1beta) and schizophrenia

Abstract

Keywords

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