Association of polymorphic VNTR region in the first intron of the human TH gene with disturbances of the catecholamine pathway in schizophrenia

J Wei, C N Ramchand, G P Hemmings

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

In the present study, five allelic fragments were typed by a polymerase chain reaction (PCR) process with a pair of primers specific for the tetranucleotide (TCAT) repeat sequence in the first intron of the human tyrosine hydroxylase (TH) gene and their sizes (bp) were 114 (A), 118 (B), 122 (C), 126 (D) and 130 (E), respectively. The AE genotypic frequency was found to be significantly higher in unrelated patients with schizophrenia than in unrelated control subjects (chi 2 = 4.18, p
Original languageEnglish
Pages (from-to)83-8
Number of pages6
JournalPsychiatric Genetics
Volume5
Issue number2
Publication statusPublished - 1995

    Fingerprint

Keywords

  • Adult
  • Alleles
  • Base Sequence
  • Catecholamines
  • Female
  • Great Britain
  • Humans
  • Introns
  • Male
  • Microsatellite Repeats
  • Middle Aged
  • Minisatellite Repeats
  • Molecular Sequence Data
  • Nerve Tissue Proteins
  • Norepinephrine
  • Polymerase Chain Reaction
  • Schizophrenia
  • Tyrosine 3-Monooxygenase

Cite this