Association between interleukin-3 receptor alpha polymorphism and schizophrenia in the Chinese population

Shilong Sun, Fan Wang, Jun Wei, Lian Yuan Cao, Gui Ying Wu, Lin Lu, Therese A Kosten, Thomas R Kosten, Xiang Yang Zhang

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Abstract

Schizophrenia has been observed to be associated with various abnormalities in cytokines and cytokine receptors. Three very recent reports showed the evidence that the IL3 gene, colony stimulating factor 2 receptor alpha (CSF2RA), beta (CSF2RB) and IL-3 receptor alpha (IL3RA), the IL-specific receptor subunits for CSF2 and IL3, respectively, are associated with schizophrenia. To examine the association of the IL3RA polymorphism (rs6603272) with schizophrenia in a Chinese population, 310 physically healthy patients with schizophrenia were compared with 330 age-, sex- matched normal controls. Statistically significant differences were observed in both allelic and genotypic frequencies of the rs6603272 polymorphism (Allele, chi2=6.24, d.f.=1, p=0.013, odds ratio (OR)=1.35, 95% CI 1.07-1.71; Genotype, chi2=6.85, d.f.=2, p=0.033). Our results indicate a small but significant contribution of the IL3RA polymorphism to susceptibility to schizophrenia, suggesting that the IL3 pathway may be involved in schizophrenia.
Original languageEnglish
Pages (from-to)35-7
Number of pages3
JournalNeuroscience Letters
Volume440
Issue number1
DOIs
Publication statusPublished - 25 Jul 2008

Keywords

  • Alleles
  • Asian Continental Ancestry Group
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Humans
  • Interleukin-3 Receptor alpha Subunit
  • Male
  • Polymorphism, Genetic
  • Receptors, Interleukin-3
  • Schizophrenia

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  • Cite this

    Sun, S., Wang, F., Wei, J., Cao, L. Y., Wu, G. Y., Lu, L., Kosten, T. A., Kosten, T. R., & Zhang, X. Y. (2008). Association between interleukin-3 receptor alpha polymorphism and schizophrenia in the Chinese population. Neuroscience Letters, 440(1), 35-7. https://doi.org/10.1016/j.neulet.2008.05.029