Association between interleukin-3 receptor alpha polymorphism and schizophrenia in the Chinese population

Shilong Sun, Fan Wang, Jun Wei, Lian Yuan Cao, Gui Ying Wu, Lin Lu, Therese A Kosten, Thomas R Kosten, Xiang Yang Zhang

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22 Citations (Scopus)


Schizophrenia has been observed to be associated with various abnormalities in cytokines and cytokine receptors. Three very recent reports showed the evidence that the IL3 gene, colony stimulating factor 2 receptor alpha (CSF2RA), beta (CSF2RB) and IL-3 receptor alpha (IL3RA), the IL-specific receptor subunits for CSF2 and IL3, respectively, are associated with schizophrenia. To examine the association of the IL3RA polymorphism (rs6603272) with schizophrenia in a Chinese population, 310 physically healthy patients with schizophrenia were compared with 330 age-, sex- matched normal controls. Statistically significant differences were observed in both allelic and genotypic frequencies of the rs6603272 polymorphism (Allele, chi2=6.24, d.f.=1, p=0.013, odds ratio (OR)=1.35, 95% CI 1.07-1.71; Genotype, chi2=6.85, d.f.=2, p=0.033). Our results indicate a small but significant contribution of the IL3RA polymorphism to susceptibility to schizophrenia, suggesting that the IL3 pathway may be involved in schizophrenia.
Original languageEnglish
Pages (from-to)35-7
Number of pages3
JournalNeuroscience Letters
Issue number1
Publication statusPublished - 25 Jul 2008


  • Alleles
  • Asian Continental Ancestry Group
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Humans
  • Interleukin-3 Receptor alpha Subunit
  • Male
  • Polymorphism, Genetic
  • Receptors, Interleukin-3
  • Schizophrenia


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