Apolipoprotein E epsilon 4 allele frequency and age at onset of Alzheimer's disease

Yvonne Davidson, Linda Gibbons, Antonia Pritchard, Jayne Hardicre, Joanne Wren, Cheryl Stopford, Camille Julien, Jennifer Thompson, Antony Payton, Stuart M. Pickering-Brown, Neil Pendleton, Michael A. Horan, Alistair Burns, Nitin Purandare, Corinne L. Lendon, David Neary, Julie S. Snowden, David M. A. Mann

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The age distribution of the Ε4 allelic form of the apolipoprotein E gene (APOE) was investigated in 630 patients with Alzheimer’s disease (AD) with onset age ranging from 35 to 90 years. Overall, mean age at onset in APOE Ε4 allele bearers was significantly later than that in nonbearers. However, when stratified into early onset AD (EOAD) and late onset (LOAD) groups, mean age at onset in EOAD cases bearing APOE Ε4 allele was later than that in those EOAD cases without Ε4 allele, whereas in LOAD mean age at onset in cases bearing APOE Ε4 allele was earlier than in those without Ε4 allele. When analysed by decade, it was observed that 37% of the total number of APOE Ε4 allele bearers, and 43% of total number of cases with APOE Ε4/Ε4 genotype fell into the 60–69 years age class. Hence, APOE Ε4 allele frequency, at 0.44, was highest in the 60–69 years age class, progressively decreasing either side of this age group. APOE Ε4 allele therefore has its maximum impact between onset ages of between 60 and 70 years.
Original languageEnglish
Pages (from-to)60-66
Number of pages7
JournalDementia and Geriatric Cognitive Disorders
Volume23
Issue number1
DOIs
Publication statusPublished - 2007

Keywords

  • Alzheimer's disease
  • apolipoprotein E gene
  • epsilon 4 allele

Cite this

Davidson, Y., Gibbons, L., Pritchard, A., Hardicre, J., Wren, J., Stopford, C., Julien, C., Thompson, J., Payton, A., Pickering-Brown, S. M., Pendleton, N., Horan, M. A., Burns, A., Purandare, N., Lendon, C. L., Neary, D., Snowden, J. S., & Mann, D. M. A. (2007). Apolipoprotein E epsilon 4 allele frequency and age at onset of Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 23(1), 60-66. https://doi.org/10.1159/000097038