Apolipoprotein E epsilon 4 allele frequency and age at onset of Alzheimer's disease

Yvonne Davidson; Linda Gibbons; Antonia Pritchard; Jayne Hardicre; Joanne Wren; Cheryl Stopford; Camille Julien; Jennifer Thompson; Antony Payton; Stuart M. Pickering-Brown; Neil Pendleton; Michael A. Horan; Alistair Burns; Nitin Purandare; Corinne L. Lendon; David Neary; Julie S. Snowden; David M. A. Mann

doi:10.1159/000097038

Apolipoprotein E epsilon 4 allele frequency and age at onset of Alzheimer's disease

Yvonne Davidson, Linda Gibbons, Antonia Pritchard, Jayne Hardicre, Joanne Wren, Cheryl Stopford, Camille Julien, Jennifer Thompson, Antony Payton, Stuart M. Pickering-Brown, Neil Pendleton, Michael A. Horan, Alistair Burns, Nitin Purandare, Corinne L. Lendon, David Neary, Julie S. Snowden, David M. A. Mann

Division of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Abstract

The age distribution of the Ε4 allelic form of the apolipoprotein E gene (APOE) was investigated in 630 patients with Alzheimer’s disease (AD) with onset age ranging from 35 to 90 years. Overall, mean age at onset in APOE Ε4 allele bearers was significantly later than that in nonbearers. However, when stratified into early onset AD (EOAD) and late onset (LOAD) groups, mean age at onset in EOAD cases bearing APOE Ε4 allele was later than that in those EOAD cases without Ε4 allele, whereas in LOAD mean age at onset in cases bearing APOE Ε4 allele was earlier than in those without Ε4 allele. When analysed by decade, it was observed that 37% of the total number of APOE Ε4 allele bearers, and 43% of total number of cases with APOE Ε4/Ε4 genotype fell into the 60–69 years age class. Hence, APOE Ε4 allele frequency, at 0.44, was highest in the 60–69 years age class, progressively decreasing either side of this age group. APOE Ε4 allele therefore has its maximum impact between onset ages of between 60 and 70 years.

Original language	English
Pages (from-to)	60-66
Number of pages	7
Journal	Dementia and Geriatric Cognitive Disorders
Volume	23
Issue number	1
DOIs	https://doi.org/10.1159/000097038
Publication status	Published - 2007

Keywords

Alzheimer's disease
apolipoprotein E gene
epsilon 4 allele

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10.1159/000097038

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Davidson, Y., Gibbons, L., Pritchard, A., Hardicre, J., Wren, J., Stopford, C., Julien, C., Thompson, J., Payton, A., Pickering-Brown, S. M., Pendleton, N., Horan, M. A., Burns, A., Purandare, N., Lendon, C. L., Neary, D., Snowden, J. S., & Mann, D. M. A. (2007). Apolipoprotein E epsilon 4 allele frequency and age at onset of Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 23(1), 60-66. https://doi.org/10.1159/000097038

@article{32c660cc34df4d0ba1eaf33813840c0d,

title = "Apolipoprotein E epsilon 4 allele frequency and age at onset of Alzheimer's disease",

abstract = "The age distribution of the Ε4 allelic form of the apolipoprotein E gene (APOE) was investigated in 630 patients with Alzheimer{\textquoteright}s disease (AD) with onset age ranging from 35 to 90 years. Overall, mean age at onset in APOE Ε4 allele bearers was significantly later than that in nonbearers. However, when stratified into early onset AD (EOAD) and late onset (LOAD) groups, mean age at onset in EOAD cases bearing APOE Ε4 allele was later than that in those EOAD cases without Ε4 allele, whereas in LOAD mean age at onset in cases bearing APOE Ε4 allele was earlier than in those without Ε4 allele. When analysed by decade, it was observed that 37% of the total number of APOE Ε4 allele bearers, and 43% of total number of cases with APOE Ε4/Ε4 genotype fell into the 60–69 years age class. Hence, APOE Ε4 allele frequency, at 0.44, was highest in the 60–69 years age class, progressively decreasing either side of this age group. APOE Ε4 allele therefore has its maximum impact between onset ages of between 60 and 70 years.",

keywords = "Alzheimer's disease, apolipoprotein E gene, epsilon 4 allele",

author = "Yvonne Davidson and Linda Gibbons and Antonia Pritchard and Jayne Hardicre and Joanne Wren and Cheryl Stopford and Camille Julien and Jennifer Thompson and Antony Payton and Pickering-Brown, {Stuart M.} and Neil Pendleton and Horan, {Michael A.} and Alistair Burns and Nitin Purandare and Lendon, {Corinne L.} and David Neary and Snowden, {Julie S.} and Mann, {David M. A.}",

note = "{\textcopyright} 2007 S. Karger AG, Basel",

year = "2007",

doi = "10.1159/000097038",

language = "English",

volume = "23",

pages = "60--66",

journal = "Dementia and Geriatric Cognitive Disorders",

issn = "1420-8008",

publisher = "Karger Publishers",

number = "1",

}

Davidson, Y, Gibbons, L, Pritchard, A, Hardicre, J, Wren, J, Stopford, C, Julien, C, Thompson, J, Payton, A, Pickering-Brown, SM, Pendleton, N, Horan, MA, Burns, A, Purandare, N, Lendon, CL, Neary, D, Snowden, JS & Mann, DMA 2007, 'Apolipoprotein E epsilon 4 allele frequency and age at onset of Alzheimer's disease', Dementia and Geriatric Cognitive Disorders, vol. 23, no. 1, pp. 60-66. https://doi.org/10.1159/000097038

TY - JOUR

T1 - Apolipoprotein E epsilon 4 allele frequency and age at onset of Alzheimer's disease

AU - Davidson, Yvonne

AU - Gibbons, Linda

AU - Pritchard, Antonia

AU - Hardicre, Jayne

AU - Wren, Joanne

AU - Stopford, Cheryl

AU - Julien, Camille

AU - Thompson, Jennifer

AU - Payton, Antony

AU - Pickering-Brown, Stuart M.

AU - Pendleton, Neil

AU - Horan, Michael A.

AU - Burns, Alistair

AU - Purandare, Nitin

AU - Lendon, Corinne L.

AU - Neary, David

AU - Snowden, Julie S.

AU - Mann, David M. A.

PY - 2007

Y1 - 2007

N2 - The age distribution of the Ε4 allelic form of the apolipoprotein E gene (APOE) was investigated in 630 patients with Alzheimer’s disease (AD) with onset age ranging from 35 to 90 years. Overall, mean age at onset in APOE Ε4 allele bearers was significantly later than that in nonbearers. However, when stratified into early onset AD (EOAD) and late onset (LOAD) groups, mean age at onset in EOAD cases bearing APOE Ε4 allele was later than that in those EOAD cases without Ε4 allele, whereas in LOAD mean age at onset in cases bearing APOE Ε4 allele was earlier than in those without Ε4 allele. When analysed by decade, it was observed that 37% of the total number of APOE Ε4 allele bearers, and 43% of total number of cases with APOE Ε4/Ε4 genotype fell into the 60–69 years age class. Hence, APOE Ε4 allele frequency, at 0.44, was highest in the 60–69 years age class, progressively decreasing either side of this age group. APOE Ε4 allele therefore has its maximum impact between onset ages of between 60 and 70 years.

AB - The age distribution of the Ε4 allelic form of the apolipoprotein E gene (APOE) was investigated in 630 patients with Alzheimer’s disease (AD) with onset age ranging from 35 to 90 years. Overall, mean age at onset in APOE Ε4 allele bearers was significantly later than that in nonbearers. However, when stratified into early onset AD (EOAD) and late onset (LOAD) groups, mean age at onset in EOAD cases bearing APOE Ε4 allele was later than that in those EOAD cases without Ε4 allele, whereas in LOAD mean age at onset in cases bearing APOE Ε4 allele was earlier than in those without Ε4 allele. When analysed by decade, it was observed that 37% of the total number of APOE Ε4 allele bearers, and 43% of total number of cases with APOE Ε4/Ε4 genotype fell into the 60–69 years age class. Hence, APOE Ε4 allele frequency, at 0.44, was highest in the 60–69 years age class, progressively decreasing either side of this age group. APOE Ε4 allele therefore has its maximum impact between onset ages of between 60 and 70 years.

KW - Alzheimer's disease

KW - apolipoprotein E gene

KW - epsilon 4 allele

U2 - 10.1159/000097038

DO - 10.1159/000097038

M3 - Article

SN - 1420-8008

VL - 23

SP - 60

EP - 66

JO - Dementia and Geriatric Cognitive Disorders

JF - Dementia and Geriatric Cognitive Disorders

IS - 1

ER -

Apolipoprotein E epsilon 4 allele frequency and age at onset of Alzheimer's disease

Abstract

Keywords

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