Antioxidants in cardiovascular therapy: panacea or false hope?

Katarzyna Goszcz, Sherine Deakin, Garry Duthie, Derek Stewart, Stephen J Leslie, Ian Megson

Research output: Contribution to journalArticle

68 Citations (Scopus)
410 Downloads (Pure)

Abstract

Oxidative stress is a key feature of the atherothrombotic process involved in the etiology of heart attacks, ischemic strokes, and peripheral arterial disease. It stands to reason that antioxidants represent a credible therapeutic option to prevent disease progression and thereby improve outcome, but despite positive findings from in vitro studies, clinical trials have failed to consistently show benefit. The aim of this review is to re-appraise the concept of antioxidants in the prevention and management of cardiovascular disease.
In particular, the review will explore the reasons behind failed antioxidant strategies with vitamin supplements and will evaluate how flavonoids might improve cardiovascular function despite bioavailability that is not sufficiently high to directly influence antioxidant capacity. As well as reaching conclusions relating to those antioxidant strategies that might hold merit, the major myths, limitations, and pitfalls associated with this research field are explored.
Original languageEnglish
Article number29
Pages (from-to)1-22
Number of pages22
JournalFrontiers in Cardiovascular Medicine
Volume2
Issue number29
DOIs
Publication statusPublished - 6 Jul 2015

Keywords

  • antioxidants
  • vitamin C
  • vitamin E
  • carotenoids
  • polyphenols
  • vascular disease
  • N-acetylcysteine
  • allopurinol

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