An electrochemical method for detection of nucleic acid hybridisation

J M Hall, J Moore-Smith, J V Bannister, I J Higgins

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Preliminary investigations on the detection of nucleic acid hybridisation by direct electrochemical techniques are described. Initial experiments were performed with calf thymus DNA, while as a model system, plasmid DNA (pEMBL) which can be prepared in single stranded forms from each of two original double stranded plasmids (+19 and -19) was used. Electrochemical analyses have been performed using mercury pool, glassy carbon and screen printed carbon working electrodes.

Original languageEnglish
Pages (from-to)21-28
Number of pages8
JournalBiochemistry and molecular biology international
Volume32
Issue number1
Publication statusPublished - Jan 1994

Keywords

  • Animals
  • Biosensing Techniques
  • Calibration
  • Carbon
  • DNA, Complementary
  • DNA, Single-Stranded
  • Electrochemistry
  • Hydrogen-Ion Concentration
  • Nucleic Acid Hybridization

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