An electrochemical method for detection of nucleic acid hybridisation

J M Hall, J Moore-Smith, J V Bannister, I J Higgins

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Preliminary investigations on the detection of nucleic acid hybridisation by direct electrochemical techniques are described. Initial experiments were performed with calf thymus DNA, while as a model system, plasmid DNA (pEMBL) which can be prepared in single stranded forms from each of two original double stranded plasmids (+19 and -19) was used. Electrochemical analyses have been performed using mercury pool, glassy carbon and screen printed carbon working electrodes.

Original languageEnglish
Pages (from-to)21-28
Number of pages8
JournalBiochemistry and molecular biology international
Volume32
Issue number1
Publication statusPublished - Jan 1994

Keywords

  • Animals
  • Biosensing Techniques
  • Calibration
  • Carbon
  • DNA, Complementary
  • DNA, Single-Stranded
  • Electrochemistry
  • Hydrogen-Ion Concentration
  • Nucleic Acid Hybridization

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