Altered nitric oxide bioavailability contributes to diesel exhaust inhalation-induced cardiovascular dysfunction in man

Jeremy P Langrish, Jon Unosson, Jenny Bosson, Stefan Barath, Ala Muala, Scott Blackwell, Stefan Söderberg, Jamshid Pourazar, Ian L Megson, Andrew Treweeke, Thomas Sandström, David E Newby, Anders Blomberg, Nicholas L Mills

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42 Citations (Scopus)

Abstract

Diesel exhaust inhalation causes cardiovascular dysfunction including impaired vascular reactivity, increased blood pressure, and arterial stiffness. We investigated the role of nitric oxide (NO) bioavailability in mediating these effects.
Original languageEnglish
Pages (from-to)e004309
JournalJournal of the American Heart Association
Volume2
Issue number1
DOIs
Publication statusPublished - Feb 2013

Keywords

  • Adult
  • Air Pollutants
  • Arginine
  • Biological Availability
  • Blood Pressure
  • Cardiac Output
  • Cardiovascular Diseases
  • Cross-Over Studies
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Enzyme Inhibitors
  • Female
  • Forearm
  • Hemodynamics
  • Humans
  • Inhalation Exposure
  • Male
  • Nitric Oxide
  • Nitric Oxide Donors
  • Nitric Oxide Synthase
  • Nitrites
  • Time Factors
  • Vascular Resistance
  • Vascular Stiffness
  • Vasoconstriction
  • Vasodilation
  • Vasodilator Agents
  • Vehicle Emissions
  • Young Adult

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  • Cite this

    Langrish, J. P., Unosson, J., Bosson, J., Barath, S., Muala, A., Blackwell, S., Söderberg, S., Pourazar, J., Megson, I. L., Treweeke, A., Sandström, T., Newby, D. E., Blomberg, A., & Mills, N. L. (2013). Altered nitric oxide bioavailability contributes to diesel exhaust inhalation-induced cardiovascular dysfunction in man. Journal of the American Heart Association, 2(1), e004309. https://doi.org/10.1161/JAHA.112.004309