Altered nitric oxide bioavailability contributes to diesel exhaust inhalation-induced cardiovascular dysfunction in man

Jeremy P Langrish; Jon Unosson; Jenny Bosson; Stefan Barath; Ala Muala; Scott Blackwell; Stefan Söderberg; Jamshid Pourazar; Ian L Megson; Andrew Treweeke; Thomas Sandström; David E Newby; Anders Blomberg; Nicholas L Mills

doi:10.1161/JAHA.112.004309

Altered nitric oxide bioavailability contributes to diesel exhaust inhalation-induced cardiovascular dysfunction in man

Jeremy P Langrish, Jon Unosson, Jenny Bosson, Stefan Barath, Ala Muala, Scott Blackwell, Stefan Söderberg, Jamshid Pourazar, Ian L Megson, Andrew Treweeke, Thomas Sandström, David E Newby, Anders Blomberg, Nicholas L Mills

Research output: Contribution to journal › Article › peer-review

70 Citations (Scopus)

Abstract

Diesel exhaust inhalation causes cardiovascular dysfunction including impaired vascular reactivity, increased blood pressure, and arterial stiffness. We investigated the role of nitric oxide (NO) bioavailability in mediating these effects.

Original language	English
Pages (from-to)	e004309
Journal	Journal of the American Heart Association
Volume	2
Issue number	1
DOIs	https://doi.org/10.1161/JAHA.112.004309
Publication status	Published - Feb 2013

Keywords

Adult
Air Pollutants
Arginine
Biological Availability
Blood Pressure
Cardiac Output
Cardiovascular Diseases
Cross-Over Studies
Dose-Response Relationship, Drug
Double-Blind Method
Enzyme Inhibitors
Female
Forearm
Hemodynamics
Humans
Inhalation Exposure
Male
Nitric Oxide
Nitric Oxide Donors
Nitric Oxide Synthase
Nitrites
Time Factors
Vascular Resistance
Vascular Stiffness
Vasoconstriction
Vasodilation
Vasodilator Agents
Vehicle Emissions
Young Adult

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1161/JAHA.112.004309

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Langrish, J. P., Unosson, J., Bosson, J., Barath, S., Muala, A., Blackwell, S., Söderberg, S., Pourazar, J., Megson, I. L., Treweeke, A., Sandström, T., Newby, D. E., Blomberg, A., & Mills, N. L. (2013). Altered nitric oxide bioavailability contributes to diesel exhaust inhalation-induced cardiovascular dysfunction in man. Journal of the American Heart Association, 2(1), e004309. https://doi.org/10.1161/JAHA.112.004309

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title = "Altered nitric oxide bioavailability contributes to diesel exhaust inhalation-induced cardiovascular dysfunction in man",

abstract = "Diesel exhaust inhalation causes cardiovascular dysfunction including impaired vascular reactivity, increased blood pressure, and arterial stiffness. We investigated the role of nitric oxide (NO) bioavailability in mediating these effects.",

keywords = "Adult, Air Pollutants, Arginine, Biological Availability, Blood Pressure, Cardiac Output, Cardiovascular Diseases, Cross-Over Studies, Dose-Response Relationship, Drug, Double-Blind Method, Enzyme Inhibitors, Female, Forearm, Hemodynamics, Humans, Inhalation Exposure, Male, Nitric Oxide, Nitric Oxide Donors, Nitric Oxide Synthase, Nitrites, Time Factors, Vascular Resistance, Vascular Stiffness, Vasoconstriction, Vasodilation, Vasodilator Agents, Vehicle Emissions, Young Adult",

author = "Langrish, {Jeremy P} and Jon Unosson and Jenny Bosson and Stefan Barath and Ala Muala and Scott Blackwell and Stefan S{\"o}derberg and Jamshid Pourazar and Megson, {Ian L} and Andrew Treweeke and Thomas Sandstr{\"o}m and Newby, {David E} and Anders Blomberg and Mills, {Nicholas L}",

year = "2013",

month = feb,

doi = "10.1161/JAHA.112.004309",

language = "English",

volume = "2",

pages = "e004309",

journal = "Journal of the American Heart Association",

issn = "2047-9980",

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Langrish, JP, Unosson, J, Bosson, J, Barath, S, Muala, A, Blackwell, S, Söderberg, S, Pourazar, J, Megson, IL , Treweeke, A, Sandström, T, Newby, DE, Blomberg, A & Mills, NL 2013, 'Altered nitric oxide bioavailability contributes to diesel exhaust inhalation-induced cardiovascular dysfunction in man', Journal of the American Heart Association, vol. 2, no. 1, pp. e004309. https://doi.org/10.1161/JAHA.112.004309

TY - JOUR

T1 - Altered nitric oxide bioavailability contributes to diesel exhaust inhalation-induced cardiovascular dysfunction in man

AU - Langrish, Jeremy P

AU - Unosson, Jon

AU - Bosson, Jenny

AU - Barath, Stefan

AU - Muala, Ala

AU - Blackwell, Scott

AU - Söderberg, Stefan

AU - Pourazar, Jamshid

AU - Megson, Ian L

AU - Treweeke, Andrew

AU - Sandström, Thomas

AU - Newby, David E

AU - Blomberg, Anders

AU - Mills, Nicholas L

PY - 2013/2

Y1 - 2013/2

N2 - Diesel exhaust inhalation causes cardiovascular dysfunction including impaired vascular reactivity, increased blood pressure, and arterial stiffness. We investigated the role of nitric oxide (NO) bioavailability in mediating these effects.

AB - Diesel exhaust inhalation causes cardiovascular dysfunction including impaired vascular reactivity, increased blood pressure, and arterial stiffness. We investigated the role of nitric oxide (NO) bioavailability in mediating these effects.

KW - Adult

KW - Air Pollutants

KW - Arginine

KW - Biological Availability

KW - Blood Pressure

KW - Cardiac Output

KW - Cardiovascular Diseases

KW - Cross-Over Studies

KW - Dose-Response Relationship, Drug

KW - Double-Blind Method

KW - Enzyme Inhibitors

KW - Female

KW - Forearm

KW - Hemodynamics

KW - Humans

KW - Inhalation Exposure

KW - Male

KW - Nitric Oxide

KW - Nitric Oxide Donors

KW - Nitric Oxide Synthase

KW - Nitrites

KW - Time Factors

KW - Vascular Resistance

KW - Vascular Stiffness

KW - Vasoconstriction

KW - Vasodilation

KW - Vasodilator Agents

KW - Vehicle Emissions

KW - Young Adult

U2 - 10.1161/JAHA.112.004309

DO - 10.1161/JAHA.112.004309

M3 - Article

C2 - 23525434

SN - 2047-9980

VL - 2

SP - e004309

JO - Journal of the American Heart Association

JF - Journal of the American Heart Association

IS - 1

ER -

Altered nitric oxide bioavailability contributes to diesel exhaust inhalation-induced cardiovascular dysfunction in man

Abstract

Keywords

UN SDGs

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