Acute cardiovascular effects of apelin in humans: potential role in patients with chronic heart failure

A G Japp; N L Cruden; G Barnes; N van Gemeren; J Mathews; J Adamson; N R Johnston; M A Denvir; I L Megson; A D Flapan; D E Newby

doi:10.1161/CIRCULATIONAHA.109.911339

Acute cardiovascular effects of apelin in humans: potential role in patients with chronic heart failure

A G Japp, N L Cruden, G Barnes, N van Gemeren, J Mathews, J Adamson, N R Johnston, M A Denvir, I L Megson, A D Flapan, D E Newby

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Abstract

Apelin, the endogenous ligand for the novel G protein-coupled receptor APJ, has major cardiovascular effects in preclinical models. The study objectives were to establish the effects of acute apelin administration on peripheral, cardiac, and systemic hemodynamic variables in healthy volunteers and patients with heart failure.

Original language	English
Pages (from-to)	1818-27
Number of pages	10
Journal	Circulation
Volume	121
Issue number	16
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.109.911339
Publication status	Published - 2010

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title = "Acute cardiovascular effects of apelin in humans: potential role in patients with chronic heart failure",

abstract = "Apelin, the endogenous ligand for the novel G protein-coupled receptor APJ, has major cardiovascular effects in preclinical models. The study objectives were to establish the effects of acute apelin administration on peripheral, cardiac, and systemic hemodynamic variables in healthy volunteers and patients with heart failure.",

author = "Japp, {A G} and Cruden, {N L} and G Barnes and {van Gemeren}, N and J Mathews and J Adamson and Johnston, {N R} and Denvir, {M A} and Megson, {I L} and Flapan, {A D} and Newby, {D E}",

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doi = "10.1161/CIRCULATIONAHA.109.911339",

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T1 - Acute cardiovascular effects of apelin in humans

T2 - potential role in patients with chronic heart failure

AU - Japp, A G

AU - Cruden, N L

AU - Barnes, G

AU - van Gemeren, N

AU - Mathews, J

AU - Adamson, J

AU - Johnston, N R

AU - Denvir, M A

AU - Megson, I L

AU - Flapan, A D

AU - Newby, D E

PY - 2010

Y1 - 2010

N2 - Apelin, the endogenous ligand for the novel G protein-coupled receptor APJ, has major cardiovascular effects in preclinical models. The study objectives were to establish the effects of acute apelin administration on peripheral, cardiac, and systemic hemodynamic variables in healthy volunteers and patients with heart failure.

AB - Apelin, the endogenous ligand for the novel G protein-coupled receptor APJ, has major cardiovascular effects in preclinical models. The study objectives were to establish the effects of acute apelin administration on peripheral, cardiac, and systemic hemodynamic variables in healthy volunteers and patients with heart failure.

U2 - 10.1161/CIRCULATIONAHA.109.911339

DO - 10.1161/CIRCULATIONAHA.109.911339

M3 - Article

C2 - 20385929

SN - 1524-4539

VL - 121

SP - 1818

EP - 1827

JO - Circulation

JF - Circulation

IS - 16

ER -

Acute cardiovascular effects of apelin in humans: potential role in patients with chronic heart failure

Abstract

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