Apelin, the endogenous ligand for the novel G protein-coupled receptor APJ, has major cardiovascular effects in preclinical models. The study objectives were to establish the effects of acute apelin administration on peripheral, cardiac, and systemic hemodynamic variables in healthy volunteers and patients with heart failure.
Japp, A. G., Cruden, N. L., Barnes, G., van Gemeren, N., Mathews, J., Adamson, J., Johnston, N. R., Denvir, M. A., Megson, I. L., Flapan, A. D., & Newby, D. E. (2010). Acute cardiovascular effects of apelin in humans: potential role in patients with chronic heart failure. Circulation, 121(16), 1818-27. https://doi.org/10.1161/CIRCULATIONAHA.109.911339