Acute cardiovascular effects of apelin in humans: potential role in patients with chronic heart failure

A G Japp, N L Cruden, G Barnes, N van Gemeren, J Mathews, J Adamson, N R Johnston, M A Denvir, I L Megson, A D Flapan, D E Newby

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Abstract

Apelin, the endogenous ligand for the novel G protein-coupled receptor APJ, has major cardiovascular effects in preclinical models. The study objectives were to establish the effects of acute apelin administration on peripheral, cardiac, and systemic hemodynamic variables in healthy volunteers and patients with heart failure.
Original languageEnglish
Pages (from-to)1818-27
Number of pages10
JournalCirculation
Volume121
Issue number16
DOIs
Publication statusPublished - 2010

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Japp, A. G., Cruden, N. L., Barnes, G., van Gemeren, N., Mathews, J., Adamson, J., Johnston, N. R., Denvir, M. A., Megson, I. L., Flapan, A. D., & Newby, D. E. (2010). Acute cardiovascular effects of apelin in humans: potential role in patients with chronic heart failure. Circulation, 121(16), 1818-27. https://doi.org/10.1161/CIRCULATIONAHA.109.911339