Abstract
Intron 9 of the human dopamine beta-hydroxylase (DBH) gene was amplified using a long PCR procedure in unrelated patients with schizophrenia and unrelated control subjects. MspI digestion of the PCR fragments showed a two allele polymorphism. A1 and A2 Kruskal-Wallis analysis revealed a significant difference in serum DBH activity among the three groups carrying the A1/A2 genotype, the drug-free and drug treated patients, and the control subjects (H = 12.2, df = 2, p
Original language | English |
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Pages (from-to) | 77-80 |
Number of pages | 4 |
Journal | Schizophrenia Research |
Volume | 22 |
Issue number | 1 |
Publication status | Published - 18 Oct 1996 |
Keywords
- Adult
- Antipsychotic Agents
- Base Sequence
- Deoxyribonuclease HpaII
- Dopamine beta-Hydroxylase
- Female
- Genotype
- Humans
- Introns
- Male
- Middle Aged
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Schizophrenia