A study of the relationship between the DBH activity in serum and a MspI polymorphic site in intron 9 of the human DBH gene in schizophrenia

J Wei, C N Ramchand, G P Hemmings

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Intron 9 of the human dopamine beta-hydroxylase (DBH) gene was amplified using a long PCR procedure in unrelated patients with schizophrenia and unrelated control subjects. MspI digestion of the PCR fragments showed a two allele polymorphism. A1 and A2 Kruskal-Wallis analysis revealed a significant difference in serum DBH activity among the three groups carrying the A1/A2 genotype, the drug-free and drug treated patients, and the control subjects (H = 12.2, df = 2, p
Original languageEnglish
Pages (from-to)77-80
Number of pages4
JournalSchizophrenia Research
Issue number1
Publication statusPublished - 18 Oct 1996



  • Adult
  • Antipsychotic Agents
  • Base Sequence
  • Deoxyribonuclease HpaII
  • Dopamine beta-Hydroxylase
  • Female
  • Genotype
  • Humans
  • Introns
  • Male
  • Middle Aged
  • Polymerase Chain Reaction
  • Polymorphism, Restriction Fragment Length
  • Schizophrenia

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