A study of the PEMT gene in schizophrenia

Yang Liu; Haiying Zhang; Guizhi Ju; Xuan Zhang; Qi Xu; Shuzheng Liu; Yaqin Yu; Jieping Shi; Susanne Boyle; Zhenqi Wang; Yan Shen; Jun Wei

doi:10.1016/j.neulet.2007.07.038

A study of the PEMT gene in schizophrenia

Yang Liu, Haiying Zhang, Guizhi Ju, Xuan Zhang, Qi Xu, Shuzheng Liu, Yaqin Yu, Jieping Shi, Susanne Boyle, Zhenqi Wang, Yan Shen, Jun Wei

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

The phospholipid hypothesis of schizophrenia is becoming popular because of the findings from the niacin flush test, the treatment with polyunsaturated fatty acids (PUFAs), biochemical studies for the phospholipid metabolism pathway and genetic studies of phospholipase A2. The present study attempted to investigate the gene coding for phosphatidylethanolamine N-methyltransferase (PEMT), which is an important enzyme for the synthesis of membrane phospholipids. We recruited 271 Chinese parent-offspring trios of Han descent and detected 3 single nucleotide polymorphisms (SNPs) at the PEMT locus. The transmission disequilibrium test (TDT) showed allelic association for rs464396 (X2=9.4, P=0.002), but not for the other two. The 2-SNP haplotype analysis showed haplotypic association for both the rs936108-rs464396 haplotypes (X2=25.7, d.f.=3, P=0.00001) and the rs464396-rs4244593 haplotypes (X2=17.3, d.f.=3, P=0.0006). The 3-SNP haplotype analysis also showed a haplotypic association (X2=24.4, d.f.=7, P=0.0006). The present results suggest that the PEMT gene may contribute to the etiology of schizophrenia.

Original language	English
Pages (from-to)	203-6
Number of pages	4
Journal	Neuroscience Letters
Volume	424
Issue number	3
DOIs	https://doi.org/10.1016/j.neulet.2007.07.038
Publication status	Published - 13 Sept 2007

Keywords

Adult
Chi-Square Distribution
China
Family Health
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Linkage Disequilibrium
Male
Phosphatidylethanolamine N-Methyltransferase
Polymorphism, Single Nucleotide
Retrospective Studies
Schizophrenia

Access to Document

10.1016/j.neulet.2007.07.038

Handle.net

Persistent link

Cite this

@article{fd541e20c7314edc926646c67be4a130,

title = "A study of the PEMT gene in schizophrenia",

abstract = "The phospholipid hypothesis of schizophrenia is becoming popular because of the findings from the niacin flush test, the treatment with polyunsaturated fatty acids (PUFAs), biochemical studies for the phospholipid metabolism pathway and genetic studies of phospholipase A2. The present study attempted to investigate the gene coding for phosphatidylethanolamine N-methyltransferase (PEMT), which is an important enzyme for the synthesis of membrane phospholipids. We recruited 271 Chinese parent-offspring trios of Han descent and detected 3 single nucleotide polymorphisms (SNPs) at the PEMT locus. The transmission disequilibrium test (TDT) showed allelic association for rs464396 (X2=9.4, P=0.002), but not for the other two. The 2-SNP haplotype analysis showed haplotypic association for both the rs936108-rs464396 haplotypes (X2=25.7, d.f.=3, P=0.00001) and the rs464396-rs4244593 haplotypes (X2=17.3, d.f.=3, P=0.0006). The 3-SNP haplotype analysis also showed a haplotypic association (X2=24.4, d.f.=7, P=0.0006). The present results suggest that the PEMT gene may contribute to the etiology of schizophrenia.",

keywords = "Adult, Chi-Square Distribution, China, Family Health, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Linkage Disequilibrium, Male, Phosphatidylethanolamine N-Methyltransferase, Polymorphism, Single Nucleotide, Retrospective Studies, Schizophrenia",

author = "Yang Liu and Haiying Zhang and Guizhi Ju and Xuan Zhang and Qi Xu and Shuzheng Liu and Yaqin Yu and Jieping Shi and Susanne Boyle and Zhenqi Wang and Yan Shen and Jun Wei",

year = "2007",

month = sep,

day = "13",

doi = "10.1016/j.neulet.2007.07.038",

language = "English",

volume = "424",

pages = "203--6",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "3",

}

TY - JOUR

T1 - A study of the PEMT gene in schizophrenia

AU - Liu, Yang

AU - Zhang, Haiying

AU - Ju, Guizhi

AU - Zhang, Xuan

AU - Xu, Qi

AU - Liu, Shuzheng

AU - Yu, Yaqin

AU - Shi, Jieping

AU - Boyle, Susanne

AU - Wang, Zhenqi

AU - Shen, Yan

AU - Wei, Jun

PY - 2007/9/13

Y1 - 2007/9/13

N2 - The phospholipid hypothesis of schizophrenia is becoming popular because of the findings from the niacin flush test, the treatment with polyunsaturated fatty acids (PUFAs), biochemical studies for the phospholipid metabolism pathway and genetic studies of phospholipase A2. The present study attempted to investigate the gene coding for phosphatidylethanolamine N-methyltransferase (PEMT), which is an important enzyme for the synthesis of membrane phospholipids. We recruited 271 Chinese parent-offspring trios of Han descent and detected 3 single nucleotide polymorphisms (SNPs) at the PEMT locus. The transmission disequilibrium test (TDT) showed allelic association for rs464396 (X2=9.4, P=0.002), but not for the other two. The 2-SNP haplotype analysis showed haplotypic association for both the rs936108-rs464396 haplotypes (X2=25.7, d.f.=3, P=0.00001) and the rs464396-rs4244593 haplotypes (X2=17.3, d.f.=3, P=0.0006). The 3-SNP haplotype analysis also showed a haplotypic association (X2=24.4, d.f.=7, P=0.0006). The present results suggest that the PEMT gene may contribute to the etiology of schizophrenia.

AB - The phospholipid hypothesis of schizophrenia is becoming popular because of the findings from the niacin flush test, the treatment with polyunsaturated fatty acids (PUFAs), biochemical studies for the phospholipid metabolism pathway and genetic studies of phospholipase A2. The present study attempted to investigate the gene coding for phosphatidylethanolamine N-methyltransferase (PEMT), which is an important enzyme for the synthesis of membrane phospholipids. We recruited 271 Chinese parent-offspring trios of Han descent and detected 3 single nucleotide polymorphisms (SNPs) at the PEMT locus. The transmission disequilibrium test (TDT) showed allelic association for rs464396 (X2=9.4, P=0.002), but not for the other two. The 2-SNP haplotype analysis showed haplotypic association for both the rs936108-rs464396 haplotypes (X2=25.7, d.f.=3, P=0.00001) and the rs464396-rs4244593 haplotypes (X2=17.3, d.f.=3, P=0.0006). The 3-SNP haplotype analysis also showed a haplotypic association (X2=24.4, d.f.=7, P=0.0006). The present results suggest that the PEMT gene may contribute to the etiology of schizophrenia.

KW - Adult

KW - Chi-Square Distribution

KW - China

KW - Family Health

KW - Female

KW - Gene Frequency

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Humans

KW - Linkage Disequilibrium

KW - Male

KW - Phosphatidylethanolamine N-Methyltransferase

KW - Polymorphism, Single Nucleotide

KW - Retrospective Studies

KW - Schizophrenia

U2 - 10.1016/j.neulet.2007.07.038

DO - 10.1016/j.neulet.2007.07.038

M3 - Article

C2 - 17720317

SN - 0304-3940

VL - 424

SP - 203

EP - 206

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 3

ER -

A study of the PEMT gene in schizophrenia

Abstract

Keywords

Access to Document

Handle.net

Fingerprint

Cite this