A study of the combined effect of the CLDN5 locus and the genes for the phospholipid metabolism pathway in schizophrenia

Jun Wei, Gwynneth P Hemmings

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The present study attempts to test the combined effect of the CLDN5 gene and those for the phospholipid metabolism pathway, including PTGS1, PTGS2, PLA2G4A and PLA2G4C. We detected five single nucleotide polymorphisms (SNPs) present in these genes among 131 British family trios of schizophrenic patients. The transmission disequilibrium test (TDT) showed that BanI-SNP located in the 5'-flanking region of the PLA2G4A gene was associated with schizophrenia (chi(2) = 5.16, P = 0.023) although the others failed to show such allelic associations. The global P-value was 0.150 for 1000 permutations with the TDT analysis. The conditioning on genotype test, but not on allele test, revealed a strong association for the combination of the CLDN5 gene with the PLA2G4A gene (chi(2) = 10.17, df = 2, P = 0.006). The present results suggest that the PLA2G4A locus may be involved in schizophrenia and its combination with the CLDN5 gene may increase further the risk for the illness.
Original languageEnglish
Pages (from-to)441-5
Number of pages5
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Issue number6
Publication statusPublished - Dec 2005



  • Adult
  • Claudin-5
  • Cyclooxygenase 1
  • Female
  • Humans
  • Linkage Disequilibrium
  • Male
  • Membrane Proteins
  • Phospholipases A
  • Phospholipids
  • Polymorphism, Single Nucleotide
  • Schizophrenia

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