Abstract
Two X-linked microsatellites, (AC) n repeats at the monoamine oxidase (MAO)-A locus and (TG)n repeats at the MAO-B locus, were studied in 140 unrelated Caucasian male patients with schizophrenia and 91 unrelated Caucasian male controls. Among these subjects, we totally typed out nine alleles for the (AC) n repeats and eight alleles for the (TG) n repeats by using a PCR-based procedure. Allelic frequencies of either (AC) n repeats or (TG) n repeats were not found to be significantly different between patients and controls. However, a significant excess of the (AC)18/(TG)23 haplotype with a relative risk of 4.05 (95%; CI 1.15-14.26) was observed in patients with schizophrenia (Fisher's P = 0.011). The coefficient of linkage disequilibrium (delta) for the (AC)18/(TG)23 haplotype was 0.019 in schizophrenic patients and -0.046 in control subjects, respectively. The latter reached statistical significance (chi 2 = 6.02; df = 1; P
| Original language | English |
|---|---|
| Pages (from-to) | 177-81 |
| Number of pages | 5 |
| Journal | Psychiatric Genetics |
| Volume | 9 |
| Issue number | 4 |
| Publication status | Published - Dec 1999 |
Keywords
- Case-Control Studies
- Dinucleotide Repeats
- European Continental Ancestry Group
- Great Britain
- Haplotypes
- Humans
- Isoenzymes
- Linkage Disequilibrium
- Male
- Monoamine Oxidase
- Polymorphism, Genetic
- Schizophrenia
- X Chromosome