A study of a genetic association between the PTGS2/PLA2G4A locus and schizophrenia

J Wei, G P Hemmings

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Six single nucleotide polymorphisms (SNPs) present in the PTGS2/PLA2G4A locus were detected among 118 British family trios of schizophrenia patients. The transmission disequilibrium test showed that SNP4 located in the 5'-flanking region of the PLA2G4A gene was associated with schizophrenia and that the haplotype analysis also showed a genetic association between the PTGS2 gene and schizophrenia. Because these two genes are arranged in a head-to-head configuration and separated by just about 149kb of DNA, they may have a combined effect on susceptibility to schizophrenia in some cases.
Original languageEnglish
Pages (from-to)413-5
Number of pages3
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume70
Issue number4
DOIs
Publication statusPublished - Apr 2004

Keywords

  • Adult
  • Alleles
  • Cyclooxygenase 2
  • European Continental Ancestry Group
  • Female
  • Genetic Predisposition to Disease
  • Great Britain
  • Haplotypes
  • Humans
  • Male
  • Membrane Proteins
  • Phospholipases A
  • Polymerase Chain Reaction
  • Polymorphism, Single Nucleotide
  • Prostaglandin-Endoperoxide Synthases
  • Schizophrenia

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