Abstract
Six single nucleotide polymorphisms (SNPs) present in the PTGS2/PLA2G4A locus were detected among 118 British family trios of schizophrenia patients. The transmission disequilibrium test showed that SNP4 located in the 5'-flanking region of the PLA2G4A gene was associated with schizophrenia and that the haplotype analysis also showed a genetic association between the PTGS2 gene and schizophrenia. Because these two genes are arranged in a head-to-head configuration and separated by just about 149kb of DNA, they may have a combined effect on susceptibility to schizophrenia in some cases.
Original language | English |
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Pages (from-to) | 413-5 |
Number of pages | 3 |
Journal | Prostaglandins Leukotrienes and Essential Fatty Acids |
Volume | 70 |
Issue number | 4 |
DOIs | |
Publication status | Published - Apr 2004 |
Keywords
- Adult
- Alleles
- Cyclooxygenase 2
- European Continental Ancestry Group
- Female
- Genetic Predisposition to Disease
- Great Britain
- Haplotypes
- Humans
- Male
- Membrane Proteins
- Phospholipases A
- Polymerase Chain Reaction
- Polymorphism, Single Nucleotide
- Prostaglandin-Endoperoxide Synthases
- Schizophrenia