A novel S-nitrosothiol (RIG200) causes prolonged relaxation in dorsal hand veins with damaged endothelium

N Sogo; I B Wilkinson; H MacCallum; S Q Khan; F E Strachan; D E Newby; I L Megson; D J Webb

doi:10.1067/mcp.2000.107049

A novel S-nitrosothiol (RIG200) causes prolonged relaxation in dorsal hand veins with damaged endothelium

N Sogo, I B Wilkinson, H MacCallum, S Q Khan, F E Strachan, D E Newby, I L Megson, D J Webb

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Reduced nitric oxide bioavailability caused by endothelial dysfunction or damage is a contributory factor in the initiation and progression of a number of cardiovascular diseases. Delivery of exogenous nitric oxide is an attractive therapeutic option, but current agents lack selectivity for areas of endothelial damage. We tested the hypothesis that a novel nitric oxide donor drug, N-(S-nitroso-N-acetylpenicillamine)-2-amino-2-deoxy-1,3,4,6-tetra-O-acet yl-P-glucopyranose [RIG200], which has selective effects in endothelium-denuded isolated arteries in vitro, would exert similar effects in dorsal hand veins with experimentally damaged endothelium in vivo.

Original language	English
Pages (from-to)	75-81
Number of pages	7
Journal	Clinical Pharmacology and Therapeutics
Volume	68
Issue number	1
DOIs	https://doi.org/10.1067/mcp.2000.107049
Publication status	Published - 2000

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1067/mcp.2000.107049

Handle.net

Persistent link

Cite this

@article{f395113d05be44be97e1b117ffc341f1,

title = "A novel S-nitrosothiol (RIG200) causes prolonged relaxation in dorsal hand veins with damaged endothelium",

abstract = "Reduced nitric oxide bioavailability caused by endothelial dysfunction or damage is a contributory factor in the initiation and progression of a number of cardiovascular diseases. Delivery of exogenous nitric oxide is an attractive therapeutic option, but current agents lack selectivity for areas of endothelial damage. We tested the hypothesis that a novel nitric oxide donor drug, N-(S-nitroso-N-acetylpenicillamine)-2-amino-2-deoxy-1,3,4,6-tetra-O-acet yl-P-glucopyranose [RIG200], which has selective effects in endothelium-denuded isolated arteries in vitro, would exert similar effects in dorsal hand veins with experimentally damaged endothelium in vivo.",

author = "N Sogo and Wilkinson, {I B} and H MacCallum and Khan, {S Q} and Strachan, {F E} and Newby, {D E} and Megson, {I L} and Webb, {D J}",

year = "2000",

doi = "10.1067/mcp.2000.107049",

language = "English",

volume = "68",

pages = "75--81",

journal = "Clinical Pharmacology and Therapeutics",

issn = "0009-9236",

publisher = "Wiley-Blackwell",

number = "1",

}

TY - JOUR

T1 - A novel S-nitrosothiol (RIG200) causes prolonged relaxation in dorsal hand veins with damaged endothelium

AU - Sogo, N

AU - Wilkinson, I B

AU - MacCallum, H

AU - Khan, S Q

AU - Strachan, F E

AU - Newby, D E

AU - Megson, I L

AU - Webb, D J

PY - 2000

Y1 - 2000

N2 - Reduced nitric oxide bioavailability caused by endothelial dysfunction or damage is a contributory factor in the initiation and progression of a number of cardiovascular diseases. Delivery of exogenous nitric oxide is an attractive therapeutic option, but current agents lack selectivity for areas of endothelial damage. We tested the hypothesis that a novel nitric oxide donor drug, N-(S-nitroso-N-acetylpenicillamine)-2-amino-2-deoxy-1,3,4,6-tetra-O-acet yl-P-glucopyranose [RIG200], which has selective effects in endothelium-denuded isolated arteries in vitro, would exert similar effects in dorsal hand veins with experimentally damaged endothelium in vivo.

AB - Reduced nitric oxide bioavailability caused by endothelial dysfunction or damage is a contributory factor in the initiation and progression of a number of cardiovascular diseases. Delivery of exogenous nitric oxide is an attractive therapeutic option, but current agents lack selectivity for areas of endothelial damage. We tested the hypothesis that a novel nitric oxide donor drug, N-(S-nitroso-N-acetylpenicillamine)-2-amino-2-deoxy-1,3,4,6-tetra-O-acet yl-P-glucopyranose [RIG200], which has selective effects in endothelium-denuded isolated arteries in vitro, would exert similar effects in dorsal hand veins with experimentally damaged endothelium in vivo.

U2 - 10.1067/mcp.2000.107049

DO - 10.1067/mcp.2000.107049

M3 - Article

C2 - 10945318

SN - 0009-9236

VL - 68

SP - 75

EP - 81

JO - Clinical Pharmacology and Therapeutics

JF - Clinical Pharmacology and Therapeutics

IS - 1

ER -

A novel S-nitrosothiol (RIG200) causes prolonged relaxation in dorsal hand veins with damaged endothelium

Abstract

UN SDGs

Access to Document

Handle.net

Fingerprint

Cite this