A novel S-nitrosothiol (RIG200) causes prolonged relaxation in dorsal hand veins with damaged endothelium

N Sogo, I B Wilkinson, H MacCallum, S Q Khan, F E Strachan, D E Newby, I L Megson, D J Webb

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Abstract

Reduced nitric oxide bioavailability caused by endothelial dysfunction or damage is a contributory factor in the initiation and progression of a number of cardiovascular diseases. Delivery of exogenous nitric oxide is an attractive therapeutic option, but current agents lack selectivity for areas of endothelial damage. We tested the hypothesis that a novel nitric oxide donor drug, N-(S-nitroso-N-acetylpenicillamine)-2-amino-2-deoxy-1,3,4,6-tetra-O-acet yl-P-glucopyranose [RIG200], which has selective effects in endothelium-denuded isolated arteries in vitro, would exert similar effects in dorsal hand veins with experimentally damaged endothelium in vivo.
Original languageEnglish
Pages (from-to)75-81
Number of pages7
JournalClinical Pharmacology and Therapeutics
Volume68
Issue number1
DOIs
Publication statusPublished - 2000

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Sogo, N., Wilkinson, I. B., MacCallum, H., Khan, S. Q., Strachan, F. E., Newby, D. E., ... Webb, D. J. (2000). A novel S-nitrosothiol (RIG200) causes prolonged relaxation in dorsal hand veins with damaged endothelium. Clinical Pharmacology and Therapeutics, 68(1), 75-81. https://doi.org/10.1067/mcp.2000.107049