A novel S-nitrosothiol (RIG200) causes prolonged relaxation in dorsal hand veins with damaged endothelium

N Sogo, I B Wilkinson, H MacCallum, S Q Khan, F E Strachan, D E Newby, I L Megson, D J Webb

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Reduced nitric oxide bioavailability caused by endothelial dysfunction or damage is a contributory factor in the initiation and progression of a number of cardiovascular diseases. Delivery of exogenous nitric oxide is an attractive therapeutic option, but current agents lack selectivity for areas of endothelial damage. We tested the hypothesis that a novel nitric oxide donor drug, N-(S-nitroso-N-acetylpenicillamine)-2-amino-2-deoxy-1,3,4,6-tetra-O-acet yl-P-glucopyranose [RIG200], which has selective effects in endothelium-denuded isolated arteries in vitro, would exert similar effects in dorsal hand veins with experimentally damaged endothelium in vivo.
Original languageEnglish
Pages (from-to)75-81
Number of pages7
JournalClinical Pharmacology and Therapeutics
Volume68
Issue number1
DOIs
Publication statusPublished - 2000

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