A novel S-nitrosothiol causes prolonged and selective inhibition of platelet adhesion at sites of vascular injury

Mark R Miller; Inderraj S Hanspal; Patrick W F Hadoke; David E Newby; Adriano G Rossi; David J Webb; Ian L Megson

A novel S-nitrosothiol causes prolonged and selective inhibition of platelet adhesion at sites of vascular injury

Mark R Miller, Inderraj S Hanspal, Patrick W F Hadoke, David E Newby, Adriano G Rossi, David J Webb, Ian L Megson

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Platelet adhesion to areas of endothelial denudation following angioplasty is an important factor contributing to the limitations of this technique. Lipophilic S-nitrosothiols like S-nitroso-N-valerylpenicillamine (SNVP) are novel nitric oxide (NO) donor drugs with anti-platelet and vasodilator properties that are selective for areas of endothelial denudation. Here we assess the inhibitory effect of SNVP on platelet adhesion to angioplastied rabbit carotid arteries.

Original language	English
Pages (from-to)	853-60
Number of pages	8
Journal	Cardiovascular Research
Volume	57
Issue number	3
Publication status	Published - 2003

Cite this

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title = "A novel S-nitrosothiol causes prolonged and selective inhibition of platelet adhesion at sites of vascular injury",

abstract = "Platelet adhesion to areas of endothelial denudation following angioplasty is an important factor contributing to the limitations of this technique. Lipophilic S-nitrosothiols like S-nitroso-N-valerylpenicillamine (SNVP) are novel nitric oxide (NO) donor drugs with anti-platelet and vasodilator properties that are selective for areas of endothelial denudation. Here we assess the inhibitory effect of SNVP on platelet adhesion to angioplastied rabbit carotid arteries.",

author = "Miller, {Mark R} and Hanspal, {Inderraj S} and Hadoke, {Patrick W F} and Newby, {David E} and Rossi, {Adriano G} and Webb, {David J} and Megson, {Ian L}",

year = "2003",

language = "English",

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pages = "853--60",

journal = "Cardiovascular Research",

issn = "0008-6363",

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T1 - A novel S-nitrosothiol causes prolonged and selective inhibition of platelet adhesion at sites of vascular injury

AU - Miller, Mark R

AU - Hanspal, Inderraj S

AU - Hadoke, Patrick W F

AU - Newby, David E

AU - Rossi, Adriano G

AU - Webb, David J

AU - Megson, Ian L

PY - 2003

Y1 - 2003

N2 - Platelet adhesion to areas of endothelial denudation following angioplasty is an important factor contributing to the limitations of this technique. Lipophilic S-nitrosothiols like S-nitroso-N-valerylpenicillamine (SNVP) are novel nitric oxide (NO) donor drugs with anti-platelet and vasodilator properties that are selective for areas of endothelial denudation. Here we assess the inhibitory effect of SNVP on platelet adhesion to angioplastied rabbit carotid arteries.

AB - Platelet adhesion to areas of endothelial denudation following angioplasty is an important factor contributing to the limitations of this technique. Lipophilic S-nitrosothiols like S-nitroso-N-valerylpenicillamine (SNVP) are novel nitric oxide (NO) donor drugs with anti-platelet and vasodilator properties that are selective for areas of endothelial denudation. Here we assess the inhibitory effect of SNVP on platelet adhesion to angioplastied rabbit carotid arteries.

M3 - Article

C2 - 12618247

SN - 0008-6363

VL - 57

SP - 853

EP - 860

JO - Cardiovascular Research

JF - Cardiovascular Research

IS - 3

ER -

A novel S-nitrosothiol causes prolonged and selective inhibition of platelet adhesion at sites of vascular injury

Abstract

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