Platelet adhesion to areas of endothelial denudation following angioplasty is an important factor contributing to the limitations of this technique. Lipophilic S-nitrosothiols like S-nitroso-N-valerylpenicillamine (SNVP) are novel nitric oxide (NO) donor drugs with anti-platelet and vasodilator properties that are selective for areas of endothelial denudation. Here we assess the inhibitory effect of SNVP on platelet adhesion to angioplastied rabbit carotid arteries.
|Number of pages||8|
|Publication status||Published - 2003|
Miller, M. R., Hanspal, I. S., Hadoke, P. W. F., Newby, D. E., Rossi, A. G., Webb, D. J., & Megson, I. L. (2003). A novel S-nitrosothiol causes prolonged and selective inhibition of platelet adhesion at sites of vascular injury. Cardiovascular Research, 57(3), 853-60.