A novel S-nitrosothiol causes prolonged and selective inhibition of platelet adhesion at sites of vascular injury

Mark R Miller, Inderraj S Hanspal, Patrick W F Hadoke, David E Newby, Adriano G Rossi, David J Webb, Ian L Megson

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14 Citations (Scopus)

Abstract

Platelet adhesion to areas of endothelial denudation following angioplasty is an important factor contributing to the limitations of this technique. Lipophilic S-nitrosothiols like S-nitroso-N-valerylpenicillamine (SNVP) are novel nitric oxide (NO) donor drugs with anti-platelet and vasodilator properties that are selective for areas of endothelial denudation. Here we assess the inhibitory effect of SNVP on platelet adhesion to angioplastied rabbit carotid arteries.
Original languageEnglish
Pages (from-to)853-60
Number of pages8
JournalCardiovascular Research
Volume57
Issue number3
Publication statusPublished - 2003

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    Miller, M. R., Hanspal, I. S., Hadoke, P. W. F., Newby, D. E., Rossi, A. G., Webb, D. J., & Megson, I. L. (2003). A novel S-nitrosothiol causes prolonged and selective inhibition of platelet adhesion at sites of vascular injury. Cardiovascular Research, 57(3), 853-60.