This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of ¿-glutamyl transpeptidase (¿-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).
- Acute Kidney Injury
- Nitric Oxide
- Vasodilator Agents
Zhang, Q., Kulczynska, A., Webb, D. J., Megson, I. L., & Botting, N. P. (2013). A new class of NO-donor pro-drugs triggered by ¿-glutamyl transpeptidase with potential for reno-selective vasodilatation. Chemical Communications, 49(14), 1389-1391. https://doi.org/10.1039/c2cc38382a