A new class of NO-donor pro-drugs triggered by ¿-glutamyl transpeptidase with potential for reno-selective vasodilatation

Qingzhi Zhang, Agnieszka Kulczynska, David J Webb, Ian L Megson, Nigel P Botting

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of ¿-glutamyl transpeptidase (¿-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).
Original languageEnglish
Pages (from-to)1389-1391
Number of pages3
JournalChemical Communications
Volume49
Issue number14
DOIs
Publication statusPublished - 18 Feb 2013

Keywords

  • Acute Kidney Injury
  • Guanidines
  • Humans
  • Nitric Oxide
  • Prodrugs
  • Vasodilator Agents
  • gamma-Glutamyltransferase

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