A new class of NO-donor pro-drugs triggered by ¿-glutamyl transpeptidase with potential for reno-selective vasodilatation

Qingzhi Zhang; Agnieszka Kulczynska; David J Webb; Ian L Megson; Nigel P Botting

doi:10.1039/c2cc38382a

A new class of NO-donor pro-drugs triggered by ¿-glutamyl transpeptidase with potential for reno-selective vasodilatation

Qingzhi Zhang, Agnieszka Kulczynska, David J Webb, Ian L Megson, Nigel P Botting

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of ¿-glutamyl transpeptidase (¿-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).

Original language	English
Pages (from-to)	1389-1391
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	14
DOIs	https://doi.org/10.1039/c2cc38382a
Publication status	Published - 18 Feb 2013

Keywords

Acute Kidney Injury
Guanidines
Humans
Nitric Oxide
Prodrugs
Vasodilator Agents
gamma-Glutamyltransferase

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10.1039/c2cc38382a

http://www.scopus.com/inward/record.url?eid=2-s2.0-84872738180&partnerID=40&md5=49868bb517891ebacc063da22a3a36e4

Cite this

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abstract = "This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of ¿-glutamyl transpeptidase (¿-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).",

keywords = "Acute Kidney Injury, Guanidines, Humans, Nitric Oxide, Prodrugs, Vasodilator Agents, gamma-Glutamyltransferase",

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AU - Kulczynska, Agnieszka

AU - Webb, David J

AU - Megson, Ian L

AU - Botting, Nigel P

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AB - This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of ¿-glutamyl transpeptidase (¿-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).

KW - Acute Kidney Injury

KW - Guanidines

KW - Humans

KW - Nitric Oxide

KW - Prodrugs

KW - Vasodilator Agents

KW - gamma-Glutamyltransferase

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ER -

A new class of NO-donor pro-drugs triggered by ¿-glutamyl transpeptidase with potential for reno-selective vasodilatation

Abstract

Keywords

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