A new approach for creating double-stranded DNA biosensors

Sergey G. Skuridin; Yuri M. Yevdokimov; Vladimir S. Efimov; Jennifer M. Hall; Anthony P.f. Turner

doi:10.1016/0956-5663(96)89439-5

A new approach for creating double-stranded DNA biosensors

Sergey G. Skuridin
, Yuri M. Yevdokimov
, Vladimir S. Efimov
, Jennifer M. Hall
, Anthony P.f. Turner

Centre for Rural Health Sciences

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

The principle of ‘sandwich’-type biosensors based on liquid-crystalline dispersions formed from [DNA-polycation] complexes is outlined. These biosensors will find application in the determination of a range of compounds and physical factors that affect the ability of a given polycationic molecule to maintain intermolecular crosslinks between neighbouring DNA molecules. In the case of liquid-crystalline dispersions formed from [DNA-protamine] complexes, the lowest concentration of hydrolytic enzyme (trypsin) detectable was ∼ 10−14M.

Original language	English
Pages (from-to)	903-911
Journal	Biosensors and Bioelectronics
Volume	11
Issue number	9
DOIs	https://doi.org/10.1016/0956-5663(96)89439-5
Publication status	Published - 1 Jan 1996

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http://linkinghub.elsevier.com/retrieve/pii/0956566396894395

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title = "A new approach for creating double-stranded DNA biosensors",

abstract = "The principle of {\textquoteleft}sandwich{\textquoteright}-type biosensors based on liquid-crystalline dispersions formed from [DNA-polycation] complexes is outlined. These biosensors will find application in the determination of a range of compounds and physical factors that affect the ability of a given polycationic molecule to maintain intermolecular crosslinks between neighbouring DNA molecules. In the case of liquid-crystalline dispersions formed from [DNA-protamine] complexes, the lowest concentration of hydrolytic enzyme (trypsin) detectable was ∼ 10−14M.",

author = "Skuridin, \{Sergey G.\} and Yevdokimov, \{Yuri M.\} and Efimov, \{Vladimir S.\} and Hall, \{Jennifer M.\} and Turner, \{Anthony P.f.\}",

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AU - Hall, Jennifer M.

AU - Turner, Anthony P.f.

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AB - The principle of ‘sandwich’-type biosensors based on liquid-crystalline dispersions formed from [DNA-polycation] complexes is outlined. These biosensors will find application in the determination of a range of compounds and physical factors that affect the ability of a given polycationic molecule to maintain intermolecular crosslinks between neighbouring DNA molecules. In the case of liquid-crystalline dispersions formed from [DNA-protamine] complexes, the lowest concentration of hydrolytic enzyme (trypsin) detectable was ∼ 10−14M.

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A new approach for creating double-stranded DNA biosensors

Abstract

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