The principle of ‘sandwich’-type biosensors based on liquid-crystalline dispersions formed from [DNA-polycation] complexes is outlined. These biosensors will find application in the determination of a range of compounds and physical factors that affect the ability of a given polycationic molecule to maintain intermolecular crosslinks between neighbouring DNA molecules. In the case of liquid-crystalline dispersions formed from [DNA-protamine] complexes, the lowest concentration of hydrolytic enzyme (trypsin) detectable was ∼ 10−14M.
Skuridin, S. G., Yevdokimov, Y. M., Efimov, V. S., Hall, J. M., & Turner, A. P. F. (1996). A new approach for creating double-stranded DNA biosensors. Biosensors and Bioelectronics, 11(9), 903-911. https://doi.org/10.1016/0956-5663(96)89439-5