A new approach for creating double-stranded DNA biosensors

Sergey G. Skuridin, Yuri M. Yevdokimov, Vladimir S. Efimov, Jennifer M. Hall, Anthony P.f. Turner

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


The principle of ‘sandwich’-type biosensors based on liquid-crystalline dispersions formed from [DNA-polycation] complexes is outlined. These biosensors will find application in the determination of a range of compounds and physical factors that affect the ability of a given polycationic molecule to maintain intermolecular crosslinks between neighbouring DNA molecules. In the case of liquid-crystalline dispersions formed from [DNA-protamine] complexes, the lowest concentration of hydrolytic enzyme (trypsin) detectable was ∼ 10−14M.
Original languageEnglish
Pages (from-to)903-911
JournalBiosensors and Bioelectronics
Issue number9
Publication statusPublished - 1 Jan 1996


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