A genetic study of two calcium-independent cytosolic PLA2 genes in schizophrenia

Yaqin Yu, Ran Tao, Jieping Shi, Xiaojuan Zhang, Changgui Kou, Yingjun Guo, Xuan Zhang, Xie Lin, Shuzheng Liu, Guizhi Ju, Qi Xu, Hong Shang, Yan Shen, Jun Wei

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18 Citations (Scopus)

Abstract

The present study detected 9 single nucleotide polymorphisms (SNPs) at the PLA2G4C and PLA2G6 loci among 240 Chinese parent-offspring trios of Han descent. Of these 9 SNPs, 5 showed highly polymorphic in the Chinese population. They were then applied as genetic markers to test the genetic association of these two calcium-independent cytosolic PLA2 genes with schizophrenia. The transmission disequilibrium test (TDT) showed that rs1549637 at the PLA2G4C locus was the only SNP associated with the illness (chi(2) = 5.63, P = 0.018). The global P-value was 0.082 for 1000 permutations with the TDT analysis. Neither the conditional on allele test nor the conditional on genotype test showed a disease association for the combination of these two genes. Because the PLA2G4C association is so weak, this initial finding should be interpreted with caution.
Original languageEnglish
Pages (from-to)351-4
Number of pages4
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume73
Issue number5
DOIs
Publication statusPublished - Nov 2005

Keywords

  • Adult
  • China
  • Cytosol
  • Female
  • Gene Frequency
  • Genetic Linkage
  • Genetic Markers
  • Genotype
  • Group VI Phospholipases A2
  • Humans
  • Male
  • Phospholipases A
  • Phospholipases A2
  • Polymorphism, Single Nucleotide
  • Schizophrenia

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  • Cite this

    Yu, Y., Tao, R., Shi, J., Zhang, X., Kou, C., Guo, Y., Zhang, X., Lin, X., Liu, S., Ju, G., Xu, Q., Shang, H., Shen, Y., & Wei, J. (2005). A genetic study of two calcium-independent cytosolic PLA2 genes in schizophrenia. Prostaglandins Leukotrienes and Essential Fatty Acids, 73(5), 351-4. https://doi.org/10.1016/j.plefa.2005.07.003