A genetic study of two calcium-independent cytosolic PLA2 genes in schizophrenia

Yaqin Yu; Ran Tao; Jieping Shi; Xiaojuan Zhang; Changgui Kou; Yingjun Guo; Xuan Zhang; Xie Lin; Shuzheng Liu; Guizhi Ju; Qi Xu; Hong Shang; Yan Shen; Jun Wei

doi:10.1016/j.plefa.2005.07.003

A genetic study of two calcium-independent cytosolic PLA2 genes in schizophrenia

Yaqin Yu, Ran Tao, Jieping Shi, Xiaojuan Zhang, Changgui Kou, Yingjun Guo, Xuan Zhang, Xie Lin, Shuzheng Liu, Guizhi Ju, Qi Xu, Hong Shang, Yan Shen, Jun Wei

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

The present study detected 9 single nucleotide polymorphisms (SNPs) at the PLA2G4C and PLA2G6 loci among 240 Chinese parent-offspring trios of Han descent. Of these 9 SNPs, 5 showed highly polymorphic in the Chinese population. They were then applied as genetic markers to test the genetic association of these two calcium-independent cytosolic PLA2 genes with schizophrenia. The transmission disequilibrium test (TDT) showed that rs1549637 at the PLA2G4C locus was the only SNP associated with the illness (chi(2) = 5.63, P = 0.018). The global P-value was 0.082 for 1000 permutations with the TDT analysis. Neither the conditional on allele test nor the conditional on genotype test showed a disease association for the combination of these two genes. Because the PLA2G4C association is so weak, this initial finding should be interpreted with caution.

Original language	English
Pages (from-to)	351-4
Number of pages	4
Journal	Prostaglandins Leukotrienes and Essential Fatty Acids
Volume	73
Issue number	5
DOIs	https://doi.org/10.1016/j.plefa.2005.07.003
Publication status	Published - Nov 2005

Keywords

Adult
China
Cytosol
Female
Gene Frequency
Genetic Linkage
Genetic Markers
Genotype
Group VI Phospholipases A2
Humans
Male
Phospholipases A
Phospholipases A2
Polymorphism, Single Nucleotide
Schizophrenia

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10.1016/j.plefa.2005.07.003

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title = "A genetic study of two calcium-independent cytosolic PLA2 genes in schizophrenia",

abstract = "The present study detected 9 single nucleotide polymorphisms (SNPs) at the PLA2G4C and PLA2G6 loci among 240 Chinese parent-offspring trios of Han descent. Of these 9 SNPs, 5 showed highly polymorphic in the Chinese population. They were then applied as genetic markers to test the genetic association of these two calcium-independent cytosolic PLA2 genes with schizophrenia. The transmission disequilibrium test (TDT) showed that rs1549637 at the PLA2G4C locus was the only SNP associated with the illness (chi(2) = 5.63, P = 0.018). The global P-value was 0.082 for 1000 permutations with the TDT analysis. Neither the conditional on allele test nor the conditional on genotype test showed a disease association for the combination of these two genes. Because the PLA2G4C association is so weak, this initial finding should be interpreted with caution.",

keywords = "Adult, China, Cytosol, Female, Gene Frequency, Genetic Linkage, Genetic Markers, Genotype, Group VI Phospholipases A2, Humans, Male, Phospholipases A, Phospholipases A2, Polymorphism, Single Nucleotide, Schizophrenia",

author = "Yaqin Yu and Ran Tao and Jieping Shi and Xiaojuan Zhang and Changgui Kou and Yingjun Guo and Xuan Zhang and Xie Lin and Shuzheng Liu and Guizhi Ju and Qi Xu and Hong Shang and Yan Shen and Jun Wei",

year = "2005",

month = nov,

doi = "10.1016/j.plefa.2005.07.003",

language = "English",

volume = "73",

pages = "351--4",

journal = "Prostaglandins Leukotrienes and Essential Fatty Acids",

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T1 - A genetic study of two calcium-independent cytosolic PLA2 genes in schizophrenia

AU - Yu, Yaqin

AU - Tao, Ran

AU - Shi, Jieping

AU - Zhang, Xiaojuan

AU - Kou, Changgui

AU - Guo, Yingjun

AU - Zhang, Xuan

AU - Lin, Xie

AU - Liu, Shuzheng

AU - Ju, Guizhi

AU - Xu, Qi

AU - Shang, Hong

AU - Shen, Yan

AU - Wei, Jun

PY - 2005/11

Y1 - 2005/11

N2 - The present study detected 9 single nucleotide polymorphisms (SNPs) at the PLA2G4C and PLA2G6 loci among 240 Chinese parent-offspring trios of Han descent. Of these 9 SNPs, 5 showed highly polymorphic in the Chinese population. They were then applied as genetic markers to test the genetic association of these two calcium-independent cytosolic PLA2 genes with schizophrenia. The transmission disequilibrium test (TDT) showed that rs1549637 at the PLA2G4C locus was the only SNP associated with the illness (chi(2) = 5.63, P = 0.018). The global P-value was 0.082 for 1000 permutations with the TDT analysis. Neither the conditional on allele test nor the conditional on genotype test showed a disease association for the combination of these two genes. Because the PLA2G4C association is so weak, this initial finding should be interpreted with caution.

AB - The present study detected 9 single nucleotide polymorphisms (SNPs) at the PLA2G4C and PLA2G6 loci among 240 Chinese parent-offspring trios of Han descent. Of these 9 SNPs, 5 showed highly polymorphic in the Chinese population. They were then applied as genetic markers to test the genetic association of these two calcium-independent cytosolic PLA2 genes with schizophrenia. The transmission disequilibrium test (TDT) showed that rs1549637 at the PLA2G4C locus was the only SNP associated with the illness (chi(2) = 5.63, P = 0.018). The global P-value was 0.082 for 1000 permutations with the TDT analysis. Neither the conditional on allele test nor the conditional on genotype test showed a disease association for the combination of these two genes. Because the PLA2G4C association is so weak, this initial finding should be interpreted with caution.

KW - Adult

KW - China

KW - Cytosol

KW - Female

KW - Gene Frequency

KW - Genetic Linkage

KW - Genetic Markers

KW - Genotype

KW - Group VI Phospholipases A2

KW - Humans

KW - Male

KW - Phospholipases A

KW - Phospholipases A2

KW - Polymorphism, Single Nucleotide

KW - Schizophrenia

U2 - 10.1016/j.plefa.2005.07.003

DO - 10.1016/j.plefa.2005.07.003

M3 - Article

C2 - 16115752

SN - 0952-3278

VL - 73

SP - 351

EP - 354

JO - Prostaglandins Leukotrienes and Essential Fatty Acids

JF - Prostaglandins Leukotrienes and Essential Fatty Acids

IS - 5

ER -

A genetic study of two calcium-independent cytosolic PLA2 genes in schizophrenia

Abstract

Keywords

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