Abstract
Several studies suggest that the X chromosome may contain a gene for schizophrenia. In the present study, we recruited 142 male schizophrenic patients and their biological mothers from all parts of the United Kingdom to detect a genetic association for the SYP/CACNA1F locus in the Xp11 region and the FACL4 locus in the Xq22.3-Xq23 region. The haplotype-based haplotype relative risk (HHRR) analysis showed allelic association for rs2071316 (chi2=6.85, P=0.009) and rs5905724 (chi2=5.3, P=0.021) at the CACNA1F locus, but not for rs5943414 and rs1324805 at the FACL4 locus and rs3817678 at the SYP locus. The haplotype analysis showed a weak association for the rs3817678-rs2071316-rs5905724 haplotypes (chi2=12.19, df=4, P=0.016) but did not show such an association for the rs5943414-rs1324805 haplotypes (chi2=3.96, df=2, P=0.138). Because the linkage disequilibrium signal was detected only at the CACNA1F locus, this gene should perhaps be considered as being a candidate for schizophrenia although further work is needed to draw firm conclusions.
| Original language | English |
|---|---|
| Pages (from-to) | 1241-5 |
| Number of pages | 5 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 344 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 16 Jun 2006 |
Keywords
- Calcium Channels, L-Type
- Chromosome Mapping
- Chromosomes, Human, X
- Coenzyme A Ligases
- Female
- Gene Frequency
- Haplotypes
- Humans
- Linkage Disequilibrium
- Male
- Polymorphism, Single Nucleotide
- Schizophrenia