A further study of a possible locus for schizophrenia on the X chromosome

Jun Wei, Gwynneth P Hemmings

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Several studies suggest that the X chromosome may contain a gene for schizophrenia. In the present study, we recruited 142 male schizophrenic patients and their biological mothers from all parts of the United Kingdom to detect a genetic association for the SYP/CACNA1F locus in the Xp11 region and the FACL4 locus in the Xq22.3-Xq23 region. The haplotype-based haplotype relative risk (HHRR) analysis showed allelic association for rs2071316 (chi2=6.85, P=0.009) and rs5905724 (chi2=5.3, P=0.021) at the CACNA1F locus, but not for rs5943414 and rs1324805 at the FACL4 locus and rs3817678 at the SYP locus. The haplotype analysis showed a weak association for the rs3817678-rs2071316-rs5905724 haplotypes (chi2=12.19, df=4, P=0.016) but did not show such an association for the rs5943414-rs1324805 haplotypes (chi2=3.96, df=2, P=0.138). Because the linkage disequilibrium signal was detected only at the CACNA1F locus, this gene should perhaps be considered as being a candidate for schizophrenia although further work is needed to draw firm conclusions.
Original languageEnglish
Pages (from-to)1241-5
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume344
Issue number4
DOIs
Publication statusPublished - 16 Jun 2006

Keywords

  • Calcium Channels, L-Type
  • Chromosome Mapping
  • Chromosomes, Human, X
  • Coenzyme A Ligases
  • Female
  • Gene Frequency
  • Haplotypes
  • Humans
  • Linkage Disequilibrium
  • Male
  • Polymorphism, Single Nucleotide
  • Schizophrenia

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