Projects per year
- Redox biochemistry
- Mitochondrial reactive oxygen species
- Synapse pruning
I am a redox biochemistry researcher with a particular interest in how the production and metabolism of mitochondrial reactive oxygen species like superoxide and hydrogen peroxide impact development.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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The effect of physical activity on appetite control and free-living energy intake in older adults: A pilot study.
12/09/22 → …
2/11/20 → 2/11/21
Influence of complex I mediated superoxide production on fertility: Implications for in vitro fertilisation
3/09/19 → 2/03/21
Oxiforms: Unique cysteine residue- and chemotype-specified chemical combinations can produce functionally-distinct proteoformsCobley, J. N., 5 May 2023, (E-pub ahead of print) In: BioEssays : news and reviews in molecular, cellular and developmental biology. 45, 7, p. e2200248
Research output: Contribution to journal › Article › peer-reviewOpen Access1 Citation (Scopus)
Performance benchmarking microplate-immunoassays for quantifying target-specific cysteine oxidation reveals their potential for understanding redox-regulation and oxidative stressTuncay, A., Crabtree, D. R., Muggeridge, D. J., Husi, H. & Cobley, J. N., 14 May 2023, In: Free Radical Biology & Medicine. 204, p. 252-265
Research output: Contribution to journal › Article › peer-reviewOpen Access
Exercise decreases PP2A-specific reversible thiol oxidation in human erythrocytes: Implications for redox biomarkersMuggeridge, D., Crabtree, D. R., Tuncay, A., Megson, I., Davison, G. W. & Cobley, J., 30 Mar 2022, In: Free Radical Biology & Medicine. 182, p. 73-78 6 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile1 Citation (Scopus)1 Downloads (Pure)
RedoxiFluor: A microplate technique to quantify target-specific protein thiol redox state in relative percentage and molar termsTuncay, A., Noble, A., Guille, M. & Cobley, J. N., 1 Mar 2022, In: Free Radical Biology & Medicine. 181, p. 118-129
Research output: Contribution to journal › Article › peer-reviewOpen Access3 Citations (Scopus)
Immunological Techniques to Assess Protein Thiol Redox State: Opportunities, Challenges and SolutionsCobley, J. N. & Husi, H., 15 Apr 2020, In: Antioxidants. 9, 4
Research output: Contribution to journal › Review article › peer-reviewOpen AccessFile15 Citations (Scopus)30 Downloads (Pure)
Mechanisms of Mitochondrial ROS Production in Assisted Reproduction: The Known, the Unknown, and the IntriguingCobley, J. N., 29 Sept 2020, In: Antioxidants. 9, 10, 31 p.
Research output: Contribution to journal › Review article › peer-reviewOpen AccessFile23 Citations (Scopus)26 Downloads (Pure)
OP2 Prophylactic, N-Acetylcysteine unsuccessful in influencing plasma antioxidant capacity in a parallel-group randomized controlled trial of patients with chronic kidney disease stage III; implications for contrast induced nephropathyRaja, KI., Hickson, K., Treweeke, AT., Rushworth, G., Morrison, E., Sandilands, E., Cobley, JN., McEneaney, D., Eddleston, M. & Megson, IL., 5 Apr 2020, p. A1.
Research output: Contribution to conference › Paper › peer-review