Photo of James Cobley
  

James Cobley

Doctor

  • IV2 3JH

    United Kingdom

Accepting PhD Students

  • 600 Citations
  • 15 h-Index
20132020
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Personal profile

Research expertise

  • Redox biochemistry
  • Mitochondrial reactive oxygen species
  • Synapse pruning
  • Microfluidics
  • Exercise

Research expertise

I am a redox biochemistry researcher with a particular interest in how the production and metabolism of mitochondrial reactive oxygen species like superoxide and hydrogen peroxide impact development. 

Fingerprint Dive into the research topics where James Cobley is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 4 Similar Profiles
Oxidation-Reduction Medicine & Life Sciences
Skeletal Muscle Medicine & Life Sciences
Muscle Chemical Compounds
Exercise Medicine & Life Sciences
Muscles Medicine & Life Sciences
Reactive Oxygen Species Medicine & Life Sciences
Oxidative stress Chemical Compounds
Biomarkers Chemical Compounds

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Projects 2018 2020

Does polyphenol supplementation suppress the increase in oxidative stress and inflammation caused by reduced physical activity?

Crabtree, D., Megson, I., Hickson, K., Cobley, J., Goszcz, K., Muggeridge, D. & Gorely, T.

24/04/18 → 1/06/20

Project: Research

Research Output 2013 2019

  • 600 Citations
  • 15 h-Index
  • 10 Article
  • 2 Review article
29 Downloads (Pure)

Catalyst-free Click PEGylation reveals substantial mitochondrial ATP synthase sub-unit alpha oxidation before and after fertilisation

Cobley, J., Husi, H. & Jimenez Fernandez, E., 18 Jun 2019, In : Redox Biology. 26, p. 1-8 8 p., 101258.

Research output: Contribution to journal › Article

Open Access
File
Mitochondrial Proton-Translocating ATPases
Fertilization
Adenosine Triphosphate
Sulfhydryl Compounds
Oxidation
2 Citations (Scopus)
2 Downloads (Pure)

Proteomic strategies to unravel age-related redox signalling defects in skeletal muscle

Cobley, J. N., Sakellariou, G. K., Husi, H. & McDonagh, B., 20 Feb 2019, In : Free Radical Biology & Medicine. 132, p. 24-32 9 p.

Research output: Contribution to journal › Review article

Open Access
File
Proteomics
Oxidation-Reduction
Muscle
Skeletal Muscle
Defects
94 Citations (Scopus)
255 Downloads (Pure)

13 reasons why the brain is susceptible to oxidative stress

Cobley, J. & Bailey, D., 31 May 2018, In : Redox Biology. 15, p. 490-503 15 p.

Research output: Contribution to journal › Review article

Open Access
File
Oxidative stress
Brain
Oxidative Stress
Oxidation-Reduction
Free Radicals
6 Citations (Scopus)
196 Downloads (Pure)

Mitochondrial ROS cause motor deficits induced by synaptic inactivity: Implications for synapse pruning

Sidlauskaite, E., Gibson, J. W., Megson, I. L., Whitfield, P. D., Tovmasyan, A., Batinic-haberle, I., Murphy, M. P., Moult, P. R. & Cobley, J. N., 20 Mar 2018, In : Redox Biology. 16, p. 344-351 8 p.

Research output: Contribution to journal › Article

Open Access
File
Synapses
Reactive Oxygen Species
Neuromuscular Junction
Neurotoxins
Cues
26 Citations (Scopus)
1 Downloads (Pure)

Exercise redox biochemistry: Conceptual, methodological and technical recommendations

Cobley, J. N., Close, G. L., Bailey, D. M. & Davison, G. W., Aug 2017, In : Redox Biology. 12, p. 540-548 9 p.

Research output: Contribution to journal › Article

Open Access
File
Biochemistry
Oxidation-Reduction
Assays
Repair
Health