• IV2 3JH

    United Kingdom

  • IV2 3JH

    United Kingdom

  • United Kingdom

  • 7528 Citations
  • 44 h-Index
1992 …2020

Research output per year

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Research Output

  • 7528 Citations
  • 44 h-Index
  • 134 Article
  • 1 Abstract
  • 1 Meeting abstract
  • 1 Book/Film/Article review
2020

Radial artery access site complications during cardiac procedures, clinical implications and potential solutions: The role of nitric oxide

Coghill, E., Johnson, T., Morris, R., Leslie, S. & Megson, I., 26 Jan 2020, In : World Journal of Cardiology. 12, 1, p. 26 9 p.

Research output: Contribution to journalArticle

Open Access
File
2019
Open Access
File
40 Downloads (Pure)
Open Access
File
13 Downloads (Pure)

Reactive Oxygen Species (ROS), Intimal Thickening, and Subclinical Atherosclerotic Disease

Burtenshay, D., Kitching, M., Redmond, E., Megson, I. & Cahill, P., 2 Aug 2019, In : Frontiers in Cardiovascular Medicine. 6, 89.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
22 Downloads (Pure)

Synthesis of novel vanillin derivatives: novel multi-targeted scaffold ligands against Alzheimer’s disease

Scipioni, M., Kay, G., Megson, I. & Kong, P., 1 May 2019, In : Medicinal Chemistry Communications. 10, 5, p. 764-777 14 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
2018

Associations between circulating IgG antibodies to Apolipoprotein B-derived peptide antigens and acute coronary syndrome in a Chinese Han population

Hu, W., Zhang, X., Han, Y., Wang, Y., Lei, M., Megson, I. L., Wei, J. & Jin, Y., Dec 2018, In : Bioscience Reports. 38, 6, p. 1-9 9 p., BSR20180450.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
7 Downloads (Pure)

Mitochondrial ROS cause motor deficits induced by synaptic inactivity: Implications for synapse pruning

Sidlauskaite, E., Gibson, J. W., Megson, I. L., Whitfield, P. D., Tovmasyan, A., Batinic-haberle, I., Murphy, M. P., Moult, P. R. & Cobley, J. N., 20 Mar 2018, In : Redox Biology. 16, p. 344-351 8 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
207 Downloads (Pure)

To clot or not to clot? That is a free radical question

Crabtree, D. R., Muggeridge, D., Leslie, S. J., Megson, I. L. & Cobley, J. N., 9 Sep 2018, In : Journal of Physiology. 596, 20, p. 4805-4806 2 p.

Research output: Contribution to journalArticle

Open Access
File
2017

Bioactive polyphenols and cardiovascular disease: chemical antagonists, pharmacological agents or xenobiotics that drive an adaptive response?

Goszcz, K., Duthie, G. G., Stewart, D., Leslie, S. J. & Megson, I. L., 10 Jan 2017, In : British Journal of Pharmacology.

Research output: Contribution to journalBook/Film/Article review

Open Access
File
44 Citations (Scopus)
50 Downloads (Pure)
Open Access
File
15 Citations (Scopus)
108 Downloads (Pure)

Novel Vanillin Derivatives: Synthesis, anti-oxidant, DNA and Cellular protection properties

Scipioni, M., Kay, G., Megson, I. & Kong, P., 2 Dec 2017, In : European Journal of Medicinal Chemistry. p. 745-754 9 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
25 Downloads (Pure)
Open Access
File
1 Citation (Scopus)
26 Downloads (Pure)

The polyphenol delphinidin induces antioxidant effects in human umbilical vein endothelial cells through activation of endogenous glutathione: importance of using relevant concentration in in vitro systems

Goszcz, K., Duthie, G., Stewart, D. & Megson, I., 1 Apr 2017, In : Heart. 103, Issue Suppl 2; A8-A9, p. 1 1 p.

Research output: Contribution to journalMeeting abstract

Open Access
File
103 Downloads (Pure)
2016
Open Access

Lipids and cardiovascular disease: where does dietary intervention sit alongside statin therapy?

Megson, I., Zabetakis, I. & Whitfield, P. D., 18 Apr 2016, In : Food Funct..

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
27 Downloads (Pure)

The acute (immediate) effects of reflexology on arterial compliance in healthy volunteers: A randomised study

Rollinson, K., Jones, J., Scott, N., Megson, I. L. & Leslie, S. J., Feb 2016, In : Complementary therapies in clinical practice. 22, p. 16-20 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Tuning the Nitric Oxide Release from CPO-27 MOFs

Cattaneo, D., Warrender, S. J., Duncan, M. J., Kelsall, C. J., Doherty, M. K., Whitfield, P., Megson, I. & Morris, R., 26 Jan 2016, In : RSC Adv.. 17, 6, p. 14059-14067 8 p.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
95 Downloads (Pure)
2015

Antioxidants in cardiovascular therapy: panacea or false hope?

Goszcz, K., Deakin, S., Duthie, G., Stewart, D., Leslie, S. J. & Megson, I., 6 Jul 2015, In : Frontiers in Cardiovascular Medicine. 2, 29, p. 1-22 22 p., 29.

Research output: Contribution to journalArticle

Open Access
File
65 Citations (Scopus)
407 Downloads (Pure)

A study of IgG antibodies to the ApoB protein in non-ST segment elevation acute coronary syndrome

Zhang, X., Yu, B., Jin, Y., Lei, M., Zhang, X., Duan, Z., Lin, Y., Megson, I. L. & Wei, J., 2 Apr 2015, In : Scandinavian Cardiovascular Journal : SCJ. p. 1-6 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
Open Access
File
7 Citations (Scopus)
167 Downloads (Pure)

Detection of circulating IgG antibodies to apolipoprotein B100 in acute myocardial infarction

Zhang, X., Zhang, X., Lei, M., Lin, Y., Megson, I. L., Wei, J., Yu, B. & Jin, Y., 2015, In : FEBS Open Bio. 5, p. 712-6 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2014

12-hydroxyeicosatetraenoic acid is associated with variability in aspirin-induced platelet inhibition

Maskrey, B. H., Rushworth, G. F., Law, M. H., Treweeke, A. T., Wei, J., Leslie, S. J., Megson, I. L. & Whitfield, P. D., 23 Oct 2014, In : Journal of Inflammation (London, England). 11, 1, p. 33

Research output: Contribution to journalArticle

7 Citations (Scopus)

Endothelial cell oxidative stress in diabetes: a key driver of cardiovascular complications?

Shaw, A., Doherty, M. K., Mutch, N. J., MacRury, S. M. & Megson, I. L., 1 Aug 2014, In : Biochemical Society Transactions. 42, 4, p. 928-33 6 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Oat-enriched diet reduces inflammatory status assessed by circulating cell-derived microparticle concentrations in type 2 diabetes

Zhang, X., McGeoch, S. C., Megson, I. L., Macrury, S. M., Johnstone, A. M., Abraham, P., Pearson, D. W. M., de Roos, B., Holtrop, G., O'Kennedy, N. & Lobley, G. E., 7 Mar 2014, In : Molecular Nutrition and Food Research. 58, 5, p. 1322-1332 10 p.

Research output: Contribution to journalArticle

Open Access
18 Citations (Scopus)

Oat-enriched diet reduces inflammatory status assessed by circulating cell-derived microparticle concentrations in type 2 diabetes

Zhang, X., McGeoch, S. C., Megson, I., MacRury, S., Johnstone, A. M., Abraham, P., Pearson, D. W. M., De Roos, B., Holtrop, G., O'Kennedy, N. & Lobley, G. E., 7 Mar 2014, In : Molecular Nutrition and Food Research. 58, 5, p. 1322-1332 10 p.

Research output: Contribution to journalArticle

Open Access

Principal component and causal analysis of structural and acute in vitro toxicity data for nanoparticles

Wang, X. Z., Yang, Y., Li, R., McGuinnes, C., Adamson, J., Megson, I. L. & Donaldson, K., Aug 2014, In : Nanotoxicology. 8, p. 465-76 12 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Surface functionalization affects the zeta potential, coronal stability and membranolytic activity of polymeric nanoparticles

Cho, W-S., Thielbeer, F., Duffin, R., Johansson, E. M. V., Megson, I. L., Macnee, W., Bradley, M. & Donaldson, K., Mar 2014, In : Nanotoxicology. 8, p. 202-11 10 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

The 2011 Survey on Hypertensive Disorders of Pregnancy (HDP) in China: Prevalence, Risk Factors, Complications, Pregnancy and Perinatal Outcomes

Ye, C., Ruan, Y., Zou, L., Li, G., Li, C., Chen, Y., Jia, C., Megson, I. L., Wei, J. & Zhang, W., 17 Jun 2014, In : PLoS ONE. 9, 6, p. e100180

Research output: Contribution to journalArticle

63 Citations (Scopus)
2013

Altered nitric oxide bioavailability contributes to diesel exhaust inhalation-induced cardiovascular dysfunction in man

Langrish, J. P., Unosson, J., Bosson, J., Barath, S., Muala, A., Blackwell, S., Söderberg, S., Pourazar, J., Megson, I. L., Treweeke, A., Sandström, T., Newby, D. E., Blomberg, A. & Mills, N. L., Feb 2013, In : Journal of the American Heart Association. 2, 1, p. e004309

Research output: Contribution to journalArticle

42 Citations (Scopus)

A new class of NO-donor pro-drugs triggered by ¿-glutamyl transpeptidase with potential for reno-selective vasodilatation

Zhang, Q., Kulczynska, A., Webb, D. J., Megson, I. L. & Botting, N. P., 18 Feb 2013, In : Chemical Communications. 49, 14, p. 1389-1391 3 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

A randomized crossover study to assess the effect of an oat-rich diet on glycaemic control, plasma lipids and postprandial glycaemia, inflammation and oxidative stress in Type 2 diabetes

McGeoch, S. C., Johnstone, A. M., Lobley, G. E., Adamson, J., Hickson, K., Holtrop, G., Fyfe, C., Clark, L. F., Pearson, D. W. M., Abraham, P., Megson, I. L. & MacRury, S. M., Nov 2013, In : Diabetic medicine : A Journal of the British Diabetic Association. 30, 11, p. 1314-23 10 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Association between Exposure to Environmental Tobacco Smoke and Biomarkers of Oxidative Stress Among Patients Hospitalised with Acute Myocardial Infarction

Megson, I. L., Haw, S. J., Newby, D. E. & Pell, J. P., 2013, In : PLoS ONE. 8, 12, p. e81209

Research output: Contribution to journalArticle

11 Citations (Scopus)

Development and Characterization of Glutamyl-Protected N-Hydroxyguanidines as Reno-Active Nitric Oxide Donor Drugs with Therapeutic Potential in Acute Renal Failure.

Zhang, Q., Milliken, P., Kulczynska, A., Slawin, A. M. Z., Gordon, A., Kirkby, N. S., Webb, D. J., Botting, N. P. & Megson, I. L., 11 Jul 2013, In : Journal of Medicinal Chemistry. 56, 13, p. 5321-34 14 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
37 Citations (Scopus)
226 Citations (Scopus)

In vivo speciation studies and antioxidant properties of bromine in Laminaria digitata reinforce the significance of iodine accumulation for kelps

Küpper, F. C., Carpenter, L. J., Leblanc, C., Toyama, C., Uchida, Y., Maskrey, B. H., Robinson, J., Verhaeghe, E. F., Malin, G., Luther, G. W., Kroneck, P. M. H., Kloareg, B., Meyer-Klaucke, W., Muramatsu, Y., Megson, I. L., Potin, P. & Feiters, M. C., Jul 2013, In : Journal of Experimental Botany. 64, 10, p. 2653-64 12 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Novel R-roscovitine NO-donor hybrid compounds as potential pro-resolution of inflammation agents

Montanaro, G., Bertinaria, M., Rolando, B., Fruttero, R., Lucas, C. D., Dorward, D. A., Rossi, A. G., Megson, I. L. & Gasco, A., 1 Apr 2013, In : Bioorganic & Medicinal Chemistry. 21, 7, p. 2107-2116 10 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Platelet-derived microparticle count and surface molecule expression differ between subjects with and without type 2 diabetes, independently of obesity status

Zhang, X., McGeoch, S. C., Johnstone, A. M., Holtrop, G., Sneddon, A. A., Macrury, S. M., Megson, I. L., Pearson, D. W. M., Abraham, P., De Roos, B., Lobley, G. E. & O'Kennedy, N., 5 Oct 2013, In : Journal of Thrombosis and Thrombolysis.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Predictive value of in vitro assays depends on the mechanism of toxicity of metal oxide nanoparticles

Cho, W-S., Duffin, R., Bradley, M., Megson, I. L., Macnee, W., Lee, J. K., Jeong, J. & Donaldson, K., 25 Oct 2013, In : Particle and Fibre Toxicology. 10, 1, p. 55

Research output: Contribution to journalArticle

69 Citations (Scopus)
2012

Diabetic fatty liver disease is associated with specific changes in blood-borne markers

Sharma, S., Barrett, F., Adamson, J., Todd, A., Megson, I. L., Zentler-Munro, P. L. & MacRury, S. M., 2012, In : Diabetes/metabolism research and reviews. 28, 4, p. 343-8 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
1 Downloads (Pure)

Differential pro-inflammatory effects of metal oxide nanoparticles and their soluble ions in vitro and in vivo; zinc and copper nanoparticles, but not their ions, recruit eosinophils to the lungs

Cho, W-S., Duffin, R., Poland, C. A., Duschl, A., Oostingh, G. J., Macnee, W., Bradley, M., Megson, I. L. & Donaldson, K., 2012, In : Nanotoxicology. 6, 1, p. 22-35 14 p.

Research output: Contribution to journalArticle

146 Citations (Scopus)

Mechanisms for an effect of acetylcysteine on renal function after exposure to radio-graphic contrast material: study protocol

Sandilands, E. A., Cameron, S., Paterson, F., Donaldson, S., Briody, L., Crowe, J., Donnelly, J., Thompson, A., Johnston, N. R., Mackenzie, I., Uren, N., Goddard, J., Webb, D. J., Megson, I. L., Bateman, N. & Eddleston, M., 2012, In : BMC Clinical Pharmacology. 12, p. 3

Research output: Contribution to journalArticle

8 Citations (Scopus)

Metal-organic frameworks for the storage and delivery of biologically active hydrogen sulfide

Allan, P. K., Wheatley, P. S., Aldous, D., Mohideen, M. I., Tang, C., Hriljac, J. A., Megson, I. L., Chapman, K. W., De Weireld, G., Vaesen, S. & Morris, R. E., 2012, In : Dalton transactions (Cambridge, England : 2003). 41, 14, p. 4060-6 7 p.

Research output: Contribution to journalArticle

79 Citations (Scopus)

N-Acetylcysteine inhibits platelet-monocyte conjugation in patients with type 2 diabetes with depleted intraplatelet glutathione: a randomised controlled trial

Treweeke, A. T., Winterburn, T. J., Mackenzie, I., Barrett, F., Barr, C., Rushworth, G. F., Dransfield, I., Macrury, S. M. & Megson, I. L., 2012, In : Diabetologia. 55, 11, p. 2920-8 9 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

NiO and Co3O4 nanoparticles induce lung DTH-like responses and alveolar lipoproteinosis

Cho, W-S., Duffin, R., Bradley, M., Megson, I. L., Macnee, W., Howie, S. E. M. & Donaldson, K., 2012, In : The European Respiratory Journal : Official Journal of the European Society for Clinical Respiratory Physiology. 39, 3, p. 546-57 12 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Search for schizophrenia susceptibility variants at the HLA-DRB1 locus among a British population

Halley, L., Doherty, M. K., Megson, I. L., McNamara, N., Gadja, A. & Wei, J., 2012, In : Immunogenetics. 65, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Type 2 diabetes managed by diet and lifestyle: HbA1c can identify significant post-prandial hyperglycaemia

McGeoch, S. A. B., Johnstone, A. A., Lobley, G. A., Pearson, D. B., Abraham, P. B., Megson, I. & MacRury, S., 2012, In : Practical Diabetes. 29, 2, p. 58-60 3 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Zeta potential and solubility to toxic ions as mechanisms of lung inflammation caused by metal/metal oxide nanoparticles

Cho, W-S., Duffin, R., Thielbeer, F., Bradley, M., Megson, I. L., Macnee, W., Poland, C. A., Tran, C. L. & Donaldson, K., 2012, In : Toxicological Sciences : An Official Journal of the Society of Toxicology. 126, 2, p. 469-77 9 p.

Research output: Contribution to journalArticle

162 Citations (Scopus)
2011

Differential susceptibility to nitric oxide-evoked apoptosis in human inflammatory cells

Shaw, C. A., Taylor, E. L., Fox, S., Megson, I. L. & Rossi, A. G., 2011, In : Free Radical Biology & Medicine. 50, 1, p. 93-101 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Erratum: Photochemistry of trans -Cr(cyclam)(ONO) 2 +, a nitric oxide precursor (Inorganic Chemistry (2011) 50 (4453-4462) DOI:10.1021/ic200094x)

Ostrowski, A. D., Absalonson, R. O., De Leo, M. A., Wu, G., Pavlovich, J. G., Adamson, J., Azhar, B., Iretskii, A. V., Megson, I. L. & Ford, P. C., 2011, In : Inorganic Chemistry. 50, 12, p. 5848 1 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)