Research output per year
Research output per year
- 1 - 50 out of 167 results
Search results
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2024
An in vitro study to determine the impact of lipid emulsion on partitioning of a broad spectrum of drugs associated with overdose.
Barker, K., Stewart, M., Rutter, A., Whitfield, P. D. & Megson, I. L., 12 Jun 2024, In: British Journal of Anaesthesia. 10, p. 100292Research output: Contribution to journal › Article › peer-review
Open Access -
First-in-human controlled inhalation of thin graphene oxide nanosheets to study acute cardiorespiratory responses
Andrews, J. P. M., Joshi, S. S., Tzolos, E., Syed, M. B., Cuthbert, H., Crica, L. E., Lozano, N., Okwelogu, E., Raftis, J. B., Bruce, L., Poland, C. A., Duffin, R., Fokkens, P. H. B., Boere, A. J. F., Leseman, D. L. A. C., Megson, I. L., Whitfield, P. D., Ziegler, K., Tammireddy, S. & Hadjidemetriou, M. & 5 others, , 16 Feb 2024, In: Nature Nanotechnology. 19, p. 705-714 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile32 Citations (Scopus)33 Downloads (Pure) -
2023
59 First-in-Human Controlled Exposure to Inhaled Graphene Oxide
Andrews, J., Joshi, S., Tzolos, E., Syed, M., Cuthbert, H., Crica, L., Lozano, N., Raftis, J., Bruce, L., Poland, C., Duffin, R., Fokkens, P., Leseman, D., Boere, J., Megson, I., Whitfield, P., Okwelogu, E., Hadjidemetriou, M., Bussy, C. & Cassee, F. & 3 others, , 10 May 2023, In: Annals of Work Exposures and Health. 67, Supplement_1, p. i52-i53Research output: Contribution to journal › Article › peer-review
Open Access -
At-Source Hospital Wastewater Treatment to Eliminate Harmful Pharmaceuticals: A Novel Immobilised Approach Using UV-LED Activated Photocatalytic Nanomaterials
Valdivia, M., Taggart, M. A., Pap, S., Kean, A. & Megson, I. L., 30 Nov 2023. 2 p.Research output: Contribution to conference › Paper › peer-review
Open AccessFile22 Downloads (Pure) -
Blue light photoinhibition of Streptococcus mutans: potential chromophores and mechanisms
Mohamad, S. A., Megson, I. L. & Kean, A. H., 1 Nov 2023, In: Lasers in Dental Science.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Photocatalytic metallic nanomaterials immobilised onto porous structures: Future perspectives for at-source pharmaceutical removal from hospital wastewater and potential benefits over existing technologies
Valdivia, M.-T., Taggart, M., Pap, S., Kean, A., Pfleger, S. & Megson, I., 1 Apr 2023, In: Journal of water process engineering. 52, 103553.Research output: Contribution to journal › Review article › peer-review
Open AccessFile19 Citations (Scopus)119 Downloads (Pure) -
2022
Acetylcysteine has No Mechanistic Effect in Patients at Risk of Contrast-Induced Nephropathy - A Failure of Academic Clinical Science
Sandilands, E. A., Rees, J., Khuram, R., Dhuan, N., Morrison, E., Hickson, K., Wraight, J., Gray, T., Briody, L., Cameron, S., Thompson, A., Johnston, N., Uren, N., Goddard, J., Treweeke, A., Rushworth, G., Webb, D. J., Bateman, D. N., Norrie, J. & Megson, I. & 1 others, , 24 Feb 2022, In: Clinical Pharmacology and Therapeutics. 111, 6, p. 1222-1238 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)36 Downloads (Pure) -
Clinical and health economic evaluation of a post stroke arrhythmia monitoring service
Muggeridge, D., Callum, K., Macpherson, L., Howard, N., Graune, C., Megson, I., Giangreco, A., Gallacher, S., Campbell, L., Williams, G., Macaden, A. & Leslie, S. J., 31 May 2022, In: British Journal of Cardiology. 29, 2, p. 46-51 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile93 Downloads (Pure) -
Exercise decreases PP2A-specific reversible thiol oxidation in human erythrocytes: Implications for redox biomarkers
Muggeridge, D., Crabtree, D. R., Tuncay, A., Megson, I., Davison, G. W. & Cobley, J., 30 Mar 2022, In: Free Radical Biology & Medicine. 182, p. 73-78 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)74 Downloads (Pure) -
Exosomal Composition, Biogenesis and Profiling Using Point-of-Care Diagnostics-Implications for Cardiovascular Disease
Burtenshaw, D., Regan, B., Owen, K., Collins, D., McEneaney, D., Megson, I. L., Redmond, E. M. & Cahill, P. A., 1 Jun 2022, In: Frontiers in cell and developmental biology. 10, p. 853451Research output: Contribution to journal › Review article › peer-review
Open AccessFile39 Citations (Scopus)60 Downloads (Pure) -
Intermittent exposure of cultured endothelial cells to physiologically relevant fructose concentrations has a profound impact on nitric oxide production and bioenergetics
Fiorello , M., Treweeke, A., Megson, I. & Macfarlane, D., 13 May 2022, In: PLoS ONE. e0267675.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)90 Downloads (Pure) -
SILAC-Based Quantitative Proteomics to Investigate the Eicosanoid Associated Inflammatory Response in Activated Macrophages
Brace, N., Megson, I., Rossi, A. G., Doherty, M. & Whitfield, P. D., 8 Aug 2022, (Submitted) In: Journal of Inflammation (London, England). 19, 12.Research output: Contribution to journal › Article › peer-review
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2021
Measurement of Heart Rate using the Polar OH1® and Fitbit Charge 3® Wearable Devices in Healthy Adults during Light, Moderate, Vigorous and Sprint-Based Exercise: Validation Study
Muggeridge, D., Hickson, K., Davies, A., Giggins, O., Megson, I., Gorely, T. & Crabtree, D. R., 25 Mar 2021, In: JMIR mHealth and uHealth. 9, 3, p. 1-13 13 p., e25313.Research output: Contribution to journal › Article › peer-review
Open AccessFile36 Citations (Scopus)85 Downloads (Pure) -
Oxford Handbook of Medical Sciences
Megson, I. (Editor), 1 Jun 2021, 3 ed. Oxford: Oxford University Press. 1022 p. (Oxford Handbooks)Research output: Book/Report › Scholarly edition
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Why Is COVID-19 More Severe in Patients With Diabetes? The Role of Angiotensin-Converting Enzyme 2, Endothelial Dysfunction and the Immunoinflammatory System
Roberts, J., Pritchard, A. L., Treweeke, A. T., Rossi, A. G., Brace, N., Cahill, P., Macrury, S. M., Wei, J. & Megson, I. L., 3 Feb 2021, In: Frontiers in Cardiovascular Medicine. 7Research output: Contribution to journal › Review article › peer-review
Open AccessFile52 Citations (Scopus)75 Downloads (Pure) -
2020
Antibacterial efficacy from NO-releasing MOF-polymer films
Duncan, M. J., Wheatley, P. S., Coghill, E. M., Vornholt, S. M., Warrender, S. J., Megson, I. L. & Morris, R. E., 7 Oct 2020, In: Materials Advances. 1, 7, p. 2509-2519 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile27 Citations (Scopus)55 Downloads (Pure) -
OP2 Prophylactic, N-Acetylcysteine unsuccessful in influencing plasma antioxidant capacity in a parallel-group randomized controlled trial of patients with chronic kidney disease stage III; implications for contrast induced nephropathy
Raja, K., Hickson, K., Treweeke, A., Rushworth, G., Morrison, E., Sandilands, E., Cobley, J., McEneaney, D., Eddleston, M. & Megson, I., 5 Apr 2020, p. A1.Research output: Contribution to conference › Paper › peer-review
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Oxidative stress and inflammation in the development of cardiovascular disease and contrast induced nephropathy
Cervantes-Gracia, K., Raja, K., Llanas-Cornejo, D., Cobley, J. N., Megson, I. L., Chahwan, R. & Husi, H., 1 Sept 2020, In: Vessel Plus. 4, 27, 19 p., 27.Research output: Contribution to journal › Review article › peer-review
Open AccessFile14 Citations (Scopus)101 Downloads (Pure) -
P0917n-acetyl cysteine fails to impact on plasma antioxidant capacity in both a placebo controlled crossover study and a parallel group trial of patients with ckd stage iii: implications for its use as a prophylactic for contrast induced nephropathy
Raja, K., Hickson, K., Treweeke, A., Rushworth, G., Morrison, E., Sandilands, E., Cobley, J., McEneaney, D., Eddleston, M. & Megson, I., 6 Jun 2020.Research output: Contribution to conference › Abstract
Open Access -
Radial artery access site complications during cardiac procedures, clinical implications and potential solutions: The role of nitric oxide
Coghill, E., Johnson, T., Morris, R., Leslie, S. & Megson, I., 26 Jan 2020, In: World Journal of Cardiology. 12, 1, p. 26 9 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile23 Citations (Scopus)64 Downloads (Pure) -
The impact of glucose exposure on bioenergetics and function in a cultured endothelial cell model and the implications for cardiovascular health in diabetes
Fiorello, M. L., Treweeke, A., Macfarlane, D. & Megson, I., 11 Nov 2020, In: Scientific Reports. 10, 19547.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)61 Downloads (Pure) -
2019
Co-ingestion of antioxidant drinks with an unhealthy challenge meal fails to prevent post-prandial endothelial dysfunction: an open-label, crossover study in healthy older adults
Goszcz, K., Megson, I., Muggeridge, D., Treweeke, A., Hickson, K. & Adamson, J., 7 Mar 2019.Research output: Contribution to conference › Abstract › peer-review
Open AccessFile7 Citations (Scopus)94 Downloads (Pure) -
Co-ingestion of Antioxidant Drinks With an Unhealthy Challenge Meal Fails to Prevent Post-prandial Endothelial Dysfunction: An Open-Label, Crossover Study in Older Overweight Volunteers
Muggeridge, D., Goszcz, K., Treweeke, A., Adamson, J., Hickson, K., Crabtree, D. R. & Megson, I., 11 Oct 2019, In: Frontiers in Physiology. 10, p. 1293 1293.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)89 Downloads (Pure) -
Does oxidative stress contribute to toxicity in acute organophosphorus poisoning? a systematic review of the evidence
Rambabu, L., Megson, I. L. & Eddleston, M., 6 Dec 2019, (E-pub ahead of print) In: Clinical Toxicology. 58, 6, p. 437-452 16 p.Research output: Contribution to journal › Review article › peer-review
23 Citations (Scopus) -
Reactive Oxygen Species (ROS), Intimal Thickening, and Subclinical Atherosclerotic Disease
Burtenshay, D., Kitching, M., Redmond, E., Megson, I. & Cahill, P., 2 Aug 2019, In: Frontiers in Cardiovascular Medicine. 6, 89.Research output: Contribution to journal › Review article › peer-review
Open AccessFile95 Citations (Scopus)110 Downloads (Pure) -
Synthesis of novel vanillin derivatives: novel multi-targeted scaffold ligands against Alzheimer’s disease
Scipioni, M., Kay, G., Megson, I. & Kong, P., 1 May 2019, In: Medicinal Chemistry Communications. 10, 5, p. 764-777 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile37 Citations (Scopus)75 Downloads (Pure) -
2018
Associations between circulating IgG antibodies to Apolipoprotein B-derived peptide antigens and acute coronary syndrome in a Chinese Han population
Hu, W., Zhang, X., Han, Y., Wang, Y., Lei, M., Megson, I. L., Wei, J. & Jin, Y., Dec 2018, In: Bioscience Reports. 38, 6, p. 1-9 9 p., BSR20180450.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)60 Downloads (Pure) -
Mitochondrial ROS cause motor deficits induced by synaptic inactivity: Implications for synapse pruning
Sidlauskaite, E., Gibson, J. W., Megson, I. L., Whitfield, P. D., Tovmasyan, A., Batinic-haberle, I., Murphy, M. P., Moult, P. R. & Cobley, J. N., 20 Mar 2018, In: Redox Biology. 16, p. 344-351 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile47 Citations (Scopus)285 Downloads (Pure) -
To clot or not to clot? That is a free radical question
Crabtree, D. R., Muggeridge, D., Leslie, S. J., Megson, I. L. & Cobley, J. N., 9 Sept 2018, In: Journal of Physiology. 596, 20, p. 4805-4806 2 p.Research output: Contribution to journal › Editorial › peer-review
Open AccessFile1 Citation (Scopus)43 Downloads (Pure) -
2017
Bioactive polyphenols and cardiovascular disease: chemical antagonists, pharmacological agents or xenobiotics that drive an adaptive response?
Goszcz, K., Duthie, G. G., Stewart, D., Leslie, S. J. & Megson, I. L., 10 Jan 2017, In: British Journal of Pharmacology.Research output: Contribution to journal › Review article › peer-review
Open AccessFile124 Citations (Scopus)135 Downloads (Pure) -
Bioavailable concentrations of delphinidin and its metabolite, gallic acid, induce antioxidant protection associated with increased intracellular glutathione in cultured endothelial cells
Goszcz, K., Deakin, S., Duthie, G., Stewart, D. & Megson, I., 7 Sept 2017, In: Oxidative Medicine and Cellular Longevity. 2017, 17 p., 9260701.Research output: Contribution to journal › Article › peer-review
Open AccessFile52 Citations (Scopus)159 Downloads (Pure) -
Novel Vanillin Derivatives: Synthesis, anti-oxidant, DNA and Cellular protection properties
Scipioni, M., Kay, G., Megson, I. & Kong, P., 2 Dec 2017, (E-pub ahead of print) In: European Journal of Medicinal Chemistry. p. 745-754 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile36 Citations (Scopus)81 Downloads (Pure) -
Preliminary study of hypoxia-related cardiovascular mediator-markers in patients with end-stage renal disease with and without diabetes and the effects of haemodialysis
Treweeke, A., Hall, J., Lambie, S., Leslie, S. J., Megson, I. & MacRury, S., 23 May 2017, In: PLoS ONE. 12, 5, p. 1-11 11 p., e0178171.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)78 Downloads (Pure) -
The polyphenol delphinidin induces antioxidant effects in human umbilical vein endothelial cells through activation of endogenous glutathione: importance of using relevant concentration in in vitro systems
Goszcz, K., Duthie, G., Stewart, D. & Megson, I., 1 Apr 2017, In: Heart. 103, Issue Suppl 2; A8-A9, p. 1 1 p.Research output: Contribution to journal › Meeting abstract › peer-review
Open AccessFile161 Downloads (Pure) -
2016
Iodixanol Has a Favourable Fibrinolytic Profile Compared to Iohexol in Cardiac Patients Undergoing Elective Angiography: A Double-Blind, Randomized, Parallel Group Study
Treweeke, A. T., Maskrey, B. H., Hickson, K., Miller, J. H., Leslie, S. J. & Megson, I. L., 19 Jan 2016, In: PLoS ONE. 11, 1, p. e0147196Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Lipids and cardiovascular disease: where does dietary intervention sit alongside statin therapy?
Megson, I., Zabetakis, I. & Whitfield, P. D., 18 Apr 2016, In: Food Funct..Research output: Contribution to journal › Review article › peer-review
Open AccessFile24 Citations (Scopus)111 Downloads (Pure) -
The acute (immediate) effects of reflexology on arterial compliance in healthy volunteers: A randomised study
Rollinson, K., Jones, J., Scott, N., Megson, I. L. & Leslie, S. J., Feb 2016, In: Complementary therapies in clinical practice. 22, p. 16-20 5 p.Research output: Contribution to journal › Article › peer-review
8 Citations (Scopus) -
Tuning the Nitric Oxide Release from CPO-27 MOFs
Cattaneo, D., Warrender, S. J., Duncan, M. J., Kelsall, C. J., Doherty, M. K., Whitfield, P., Megson, I. & Morris, R., 26 Jan 2016, In: RSC Adv.. 17, 6, p. 14059-14067 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile57 Citations (Scopus)213 Downloads (Pure) -
2015
Antioxidants in cardiovascular therapy: panacea or false hope?
Goszcz, K., Deakin, S., Duthie, G., Stewart, D., Leslie, S. J. & Megson, I., 6 Jul 2015, In: Frontiers in Cardiovascular Medicine. 2, 29, p. 1-22 22 p., 29.Research output: Contribution to journal › Review article › peer-review
Open AccessFile150 Citations (Scopus)571 Downloads (Pure) -
A study of IgG antibodies to the ApoB protein in non-ST segment elevation acute coronary syndrome
Zhang, X., Yu, B., Jin, Y., Lei, M., Zhang, X., Duan, Z., Lin, Y., Megson, I. L. & Wei, J., 2 Apr 2015, In: Scandinavian Cardiovascular Journal : SCJ. p. 1-6 6 p.Research output: Contribution to journal › Article
1 Citation (Scopus) -
Continuous Subcutaneous Insulin Infusion in Patients With Type 2 Diabetes: A Cohort Study to Establish the Relationship Between Glucose Control and Plasma Oxidized Low Density Lipoprotein
Megson, I. L., Treweeke, A. T., Shaw, A., MacRury, S. M., Setford, S., Frias, J. P. & Anhalt, H., 29 Apr 2015, In: Journal of Diabetes Science and Technology. 9, 3, p. 573-580 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)244 Downloads (Pure) -
Detection of circulating IgG antibodies to apolipoprotein B100 in acute myocardial infarction
Zhang, X., Zhang, X., Lei, M., Lin, Y., Megson, I. L., Wei, J., Yu, B. & Jin, Y., 2015, In: FEBS Open Bio. 5, p. 712-6 5 p.Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus) -
2014
12-hydroxyeicosatetraenoic acid is associated with variability in aspirin-induced platelet inhibition
Maskrey, B. H., Rushworth, G. F., Treweeke, A. T., Wei, J., Leslie, S. J., Megson, I. L. & Whitfield, P. D., 23 Oct 2014, In: Journal of Inflammation (London, England). 11, 1, p. 33Research output: Contribution to journal › Article › peer-review
20 Citations (Scopus) -
Endothelial cell oxidative stress in diabetes: a key driver of cardiovascular complications?
Shaw, A., Doherty, M. K., Mutch, N. J., MacRury, S. M. & Megson, I. L., 1 Aug 2014, In: Biochemical Society Transactions. 42, 4, p. 928-33 6 p.Research output: Contribution to journal › Review article › peer-review
32 Citations (Scopus) -
Oat-enriched diet reduces inflammatory status assessed by circulating cell-derived microparticle concentrations in type 2 diabetes
Zhang, X., McGeoch, S. C., Megson, I. L., Macrury, S. M., Johnstone, A. M., Abraham, P., Pearson, D. W. M., de Roos, B., Holtrop, G., O'Kennedy, N. & Lobley, G. E., 7 Mar 2014, In: Molecular Nutrition and Food Research. 58, 5, p. 1322-1332 10 p.Research output: Contribution to journal › Article
Open Access35 Citations (Scopus) -
Oat-enriched diet reduces inflammatory status assessed by circulating cell-derived microparticle concentrations in type 2 diabetes
Zhang, X., McGeoch, S. C., Megson, I., MacRury, S., Johnstone, A. M., Abraham, P., Pearson, D. W. M., De Roos, B., Holtrop, G., O'Kennedy, N. & Lobley, G. E., 7 Mar 2014, In: Molecular Nutrition and Food Research. 58, 5, p. 1322-1332 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Principal component and causal analysis of structural and acute in vitro toxicity data for nanoparticles
Wang, X. Z., Yang, Y., Li, R., McGuinnes, C., Adamson, J., Megson, I. L. & Donaldson, K., 30 Aug 2014, In: Nanotoxicology. 8, p. 465-76 12 p.Research output: Contribution to journal › Article › peer-review
57 Citations (Scopus) -
Surface functionalization affects the zeta potential, coronal stability and membranolytic activity of polymeric nanoparticles
Cho, W.-S., Thielbeer, F., Duffin, R., Johansson, E. M. V., Megson, I. L., Macnee, W., Bradley, M. & Donaldson, K., Mar 2014, In: Nanotoxicology. 8, p. 202-11 10 p.Research output: Contribution to journal › Article › peer-review
91 Citations (Scopus) -
The 2011 Survey on Hypertensive Disorders of Pregnancy (HDP) in China: Prevalence, Risk Factors, Complications, Pregnancy and Perinatal Outcomes
Ye, C., Ruan, Y., Zou, L., Li, G., Li, C., Chen, Y., Jia, C., Megson, I. L., Wei, J. & Zhang, W., 17 Jun 2014, In: PLoS ONE. 9, 6, p. e100180Research output: Contribution to journal › Article
167 Citations (Scopus) -
2013
Altered nitric oxide bioavailability contributes to diesel exhaust inhalation-induced cardiovascular dysfunction in man
Langrish, J. P., Unosson, J., Bosson, J., Barath, S., Muala, A., Blackwell, S., Söderberg, S., Pourazar, J., Megson, I. L., Treweeke, A., Sandström, T., Newby, D. E., Blomberg, A. & Mills, N. L., Feb 2013, In: Journal of the American Heart Association. 2, 1, p. e004309Research output: Contribution to journal › Article › peer-review
71 Citations (Scopus)