Functional analysis of the ATM-p53-p21 pathway in the LRF CLL4 trial blockade at the level of p21 is associated with short response duration

Ke Lin; Janet Adamson; Gillian G Johnson; Anthony Carter; Melanie Oates; Rachel Wade; Sue Richards; David Gonzalez; Estella Matutes; Claire Dearden; David G Oscier; Daniel Catovsky; Andrew R Pettitt

doi:10.1158/1078-0432.CCR-11-2936

Functional analysis of the ATM-p53-p21 pathway in the LRF CLL4 trial blockade at the level of p21 is associated with short response duration

Ke Lin
, Janet Adamson
, Gillian G Johnson
, Anthony Carter
, Melanie Oates
, Rachel Wade
, Sue Richards
, David Gonzalez
, Estella Matutes
, Claire Dearden
, David G Oscier
, Daniel Catovsky
, Andrew R Pettitt

Publikation: Article › Begutachtung

29 Zitate (Scopus)

Abstract

This study sought to establish whether functional analysis of the ATM-p53-p21 pathway adds to the information provided by currently available prognostic factors in patients with chronic lymphocytic leukemia (CLL) requiring frontline chemotherapy.

Originalsprache	English
Seiten (von - bis)	4191-200
Seitenumfang	10
Fachzeitschrift	Clinical Cancer Research : An Official Journal of the American Association for Cancer Research
Jahrgang	18
Ausgabenummer	15
DOIs	https://doi.org/10.1158/1078-0432.CCR-11-2936
Publikationsstatus	Published - 1 Aug. 2012

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10.1158/1078-0432.CCR-11-2936

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Lin, K., Adamson, J., Johnson, G. G., Carter, A., Oates, M., Wade, R., Richards, S., Gonzalez, D., Matutes, E., Dearden, C., Oscier, D. G., Catovsky, D., & Pettitt, A. R. (2012). Functional analysis of the ATM-p53-p21 pathway in the LRF CLL4 trial blockade at the level of p21 is associated with short response duration. Clinical Cancer Research : An Official Journal of the American Association for Cancer Research, 18(15), 4191-200. https://doi.org/10.1158/1078-0432.CCR-11-2936

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title = "Functional analysis of the ATM-p53-p21 pathway in the LRF CLL4 trial blockade at the level of p21 is associated with short response duration",

abstract = "This study sought to establish whether functional analysis of the ATM-p53-p21 pathway adds to the information provided by currently available prognostic factors in patients with chronic lymphocytic leukemia (CLL) requiring frontline chemotherapy.",

keywords = "Aged, Antineoplastic Combined Chemotherapy Protocols, Ataxia Telangiectasia Mutated Proteins, Cell Cycle Proteins, Chlorambucil, Cyclin-Dependent Kinase Inhibitor p21, Cyclophosphamide, DNA-Binding Proteins, Female, Flow Cytometry, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Leukocytes, Mononuclear, Male, Middle Aged, Mutation, Prognosis, Protein-Serine-Threonine Kinases, Randomized Controlled Trials as Topic, Signal Transduction, Survival Analysis, Tumor Suppressor Protein p53, Tumor Suppressor Proteins, Vidarabine",

author = "Ke Lin and Janet Adamson and Johnson, \{Gillian G\} and Anthony Carter and Melanie Oates and Rachel Wade and Sue Richards and David Gonzalez and Estella Matutes and Claire Dearden and Oscier, \{David G\} and Daniel Catovsky and Pettitt, \{Andrew R\}",

year = "2012",

month = aug,

day = "1",

doi = "10.1158/1078-0432.CCR-11-2936",

language = "English",

volume = "18",

pages = "4191--200",

journal = "Clinical Cancer Research : An Official Journal of the American Association for Cancer Research",

issn = "1078-0432",

publisher = "American Association for Cancer Research Inc.",

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Lin, K, Adamson, J, Johnson, GG, Carter, A, Oates, M, Wade, R, Richards, S, Gonzalez, D, Matutes, E, Dearden, C, Oscier, DG, Catovsky, D & Pettitt, AR 2012, 'Functional analysis of the ATM-p53-p21 pathway in the LRF CLL4 trial blockade at the level of p21 is associated with short response duration', Clinical Cancer Research : An Official Journal of the American Association for Cancer Research, Jg. 18, Nr. 15, S. 4191-200. https://doi.org/10.1158/1078-0432.CCR-11-2936

Functional analysis of the ATM-p53-p21 pathway in the LRF CLL4 trial blockade at the level of p21 is associated with short response duration. / Lin, Ke; Adamson, Janet; Johnson, Gillian G et al.
in: Clinical Cancer Research : An Official Journal of the American Association for Cancer Research, Jahrgang 18, Nr. 15, 01.08.2012, S. 4191-200.

Publikation: Article › Begutachtung

TY - JOUR

T1 - Functional analysis of the ATM-p53-p21 pathway in the LRF CLL4 trial blockade at the level of p21 is associated with short response duration

AU - Lin, Ke

AU - Adamson, Janet

AU - Johnson, Gillian G

AU - Carter, Anthony

AU - Oates, Melanie

AU - Wade, Rachel

AU - Richards, Sue

AU - Gonzalez, David

AU - Matutes, Estella

AU - Dearden, Claire

AU - Oscier, David G

AU - Catovsky, Daniel

AU - Pettitt, Andrew R

PY - 2012/8/1

Y1 - 2012/8/1

N2 - This study sought to establish whether functional analysis of the ATM-p53-p21 pathway adds to the information provided by currently available prognostic factors in patients with chronic lymphocytic leukemia (CLL) requiring frontline chemotherapy.

AB - This study sought to establish whether functional analysis of the ATM-p53-p21 pathway adds to the information provided by currently available prognostic factors in patients with chronic lymphocytic leukemia (CLL) requiring frontline chemotherapy.

KW - Aged

KW - Antineoplastic Combined Chemotherapy Protocols

KW - Ataxia Telangiectasia Mutated Proteins

KW - Cell Cycle Proteins

KW - Chlorambucil

KW - Cyclin-Dependent Kinase Inhibitor p21

KW - Cyclophosphamide

KW - DNA-Binding Proteins

KW - Female

KW - Flow Cytometry

KW - Humans

KW - Leukemia, Lymphocytic, Chronic, B-Cell

KW - Leukocytes, Mononuclear

KW - Male

KW - Middle Aged

KW - Mutation

KW - Prognosis

KW - Protein-Serine-Threonine Kinases

KW - Randomized Controlled Trials as Topic

KW - Signal Transduction

KW - Survival Analysis

KW - Tumor Suppressor Protein p53

KW - Tumor Suppressor Proteins

KW - Vidarabine

U2 - 10.1158/1078-0432.CCR-11-2936

DO - 10.1158/1078-0432.CCR-11-2936

M3 - Article

C2 - 22675167

SN - 1078-0432

VL - 18

SP - 4191

EP - 4200

JO - Clinical Cancer Research : An Official Journal of the American Association for Cancer Research

JF - Clinical Cancer Research : An Official Journal of the American Association for Cancer Research

IS - 15

ER -

Functional analysis of the ATM-p53-p21 pathway in the LRF CLL4 trial blockade at the level of p21 is associated with short response duration

Abstract

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