Attack of the Subclones: Accurate Detection of Mutational Heterogeneity in Bulk DNA from Tumors

Chloe B. Rodgers; Natasa Broit; Peter A. Johansson; Antonia L. Pritchard

doi:10.1016/j.jid.2020.02.017

Attack of the Subclones: Accurate Detection of Mutational Heterogeneity in Bulk DNA from Tumors

Chloe B. Rodgers
, Natasa Broit
, Peter A. Johansson
, Antonia L. Pritchard

Publikation: Comment/debate › Begutachtung

2 Zitate (Scopus)

Abstract

Tumors are often polyclonal and are therefore heterogenous in their genomic and molecular profiles, which contributes to drug resistance and treatment failure. The methods used to detect these heterogenous differences in tumor samples are critical, but findings have been hindered by methodological inability to detect low-frequency subclones in bulk DNA. Chang et al. (2020) have addressed some of these methodological issues.

Originalsprache	English
Seiten (von - bis)	1501-1503
Seitenumfang	3
Fachzeitschrift	Journal of Investigative Dermatology
Jahrgang	140
Ausgabenummer	8
Frühes Online-Datum	21 Juli 2020
DOIs	https://doi.org/10.1016/j.jid.2020.02.017
Publikationsstatus	Published - 1 Aug. 2020

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

Good health and well being

Zugriff auf Dokument

10.1016/j.jid.2020.02.017Lizenz: CC BY-NC-ND

Andere Dateien und Links

JID-2020-0090.R1_Proof_hi

Dieses zitieren

@article{69d544f2057b4f48853f3f4516bc80a8,

title = "Attack of the Subclones: Accurate Detection of Mutational Heterogeneity in Bulk DNA from Tumors",

abstract = "Tumors are often polyclonal and are therefore heterogenous in their genomic and molecular profiles, which contributes to drug resistance and treatment failure. The methods used to detect these heterogenous differences in tumor samples are critical, but findings have been hindered by methodological inability to detect low-frequency subclones in bulk DNA. Chang et al. (2020) have addressed some of these methodological issues.",

author = "Rodgers, \{Chloe B.\} and Natasa Broit and Johansson, \{Peter A.\} and Pritchard, \{Antonia L.\}",

note = "{\textcopyright} 2020 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.",

year = "2020",

month = aug,

day = "1",

doi = "10.1016/j.jid.2020.02.017",

language = "English",

volume = "140",

pages = "1501--1503",

journal = "Journal of Investigative Dermatology",

issn = "0022-202X",

publisher = "Elsevier B.V.",

number = "8",

}

TY - JOUR

T1 - Attack of the Subclones

T2 - Accurate Detection of Mutational Heterogeneity in Bulk DNA from Tumors

AU - Rodgers, Chloe B.

AU - Broit, Natasa

AU - Johansson, Peter A.

AU - Pritchard, Antonia L.

PY - 2020/8/1

Y1 - 2020/8/1

N2 - Tumors are often polyclonal and are therefore heterogenous in their genomic and molecular profiles, which contributes to drug resistance and treatment failure. The methods used to detect these heterogenous differences in tumor samples are critical, but findings have been hindered by methodological inability to detect low-frequency subclones in bulk DNA. Chang et al. (2020) have addressed some of these methodological issues.

AB - Tumors are often polyclonal and are therefore heterogenous in their genomic and molecular profiles, which contributes to drug resistance and treatment failure. The methods used to detect these heterogenous differences in tumor samples are critical, but findings have been hindered by methodological inability to detect low-frequency subclones in bulk DNA. Chang et al. (2020) have addressed some of these methodological issues.

UR - https://www.scopus.com/pages/publications/85088273504

UR - https://www.scopus.com/pages/publications/85088273504#tab=citedBy

U2 - 10.1016/j.jid.2020.02.017

DO - 10.1016/j.jid.2020.02.017

M3 - Comment/debate

C2 - 32709275

AN - SCOPUS:85088273504

SN - 0022-202X

VL - 140

SP - 1501

EP - 1503

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

IS - 8

ER -

Attack of the Subclones: Accurate Detection of Mutational Heterogeneity in Bulk DNA from Tumors

Abstract

UN SDGs

Zugriff auf Dokument

Andere Dateien und Links

Fingerprint

Dieses zitieren