Association study of the human FZD3 locus with schizophrenia

Jianzhong Yang; Tianmei Si; Yansu Ling; Yan Ruan; Yonghua Han; Xiling Wang; Hongyan Zhang; Qingmei Kong; Xueni Li; Cui Liu; Darong Zhang; Mo Zhou; Yaqin Yu; Shuzeng Liu; Liang Shu; Dalong Ma; Jun Wei; Dai Zhang

Association study of the human FZD3 locus with schizophrenia

Jianzhong Yang
, Tianmei Si
, Yansu Ling
, Yan Ruan
, Yonghua Han
, Xiling Wang
, Hongyan Zhang
, Qingmei Kong
, Xueni Li
, Cui Liu
, Darong Zhang
, Mo Zhou
, Yaqin Yu
, Shuzeng Liu
, Liang Shu
, Dalong Ma
, Jun Wei
, Dai Zhang

Publikation: Article › Begutachtung

64 Zitate (Scopus)

Abstract

The FZD3 protein is a transmembrane receptor for secreted Wnt glycoproteins involved in the Wnt signal transduction cascades. The alteration of Wnt signal transduction cascades has been thought to be involved in producing the cytoarchitectural defects observed in schizophrenia. Because the human FZD3 gene is mapped to chromosome 8p21, which is a potential region containing a gene for schizophrenia, it may play a role in conferring susceptibility to the disease. This study was conducted with the detection of three single nucleotide polymorphisms (SNPs) located within the FZD3 locus by using the polymerase chain reaction-based restriction fragment length polymorphism (RFLP) analysis among 246 schizophrenic family trios of Chinese Han descent.The transmission disequilibrium test (TDT) demonstrated that the three SNPs all showed a preferential transmission with a p value ranging from.0003-.000007. The global chi-squared test for haplotype transmission also showed a strong association (chi(2) = 48.84, df = 7, p

Originalsprache	English
Seiten (von - bis)	1298-301
Seitenumfang	4
Fachzeitschrift	Biological Psychiatry
Jahrgang	54
Ausgabenummer	11
Publikationsstatus	Published - 1 Dez. 2003

Dieses zitieren

@article{e81b0946b202411ba4e15d38549b2ed4,

title = "Association study of the human FZD3 locus with schizophrenia",

abstract = "The FZD3 protein is a transmembrane receptor for secreted Wnt glycoproteins involved in the Wnt signal transduction cascades. The alteration of Wnt signal transduction cascades has been thought to be involved in producing the cytoarchitectural defects observed in schizophrenia. Because the human FZD3 gene is mapped to chromosome 8p21, which is a potential region containing a gene for schizophrenia, it may play a role in conferring susceptibility to the disease. This study was conducted with the detection of three single nucleotide polymorphisms (SNPs) located within the FZD3 locus by using the polymerase chain reaction-based restriction fragment length polymorphism (RFLP) analysis among 246 schizophrenic family trios of Chinese Han descent.The transmission disequilibrium test (TDT) demonstrated that the three SNPs all showed a preferential transmission with a p value ranging from.0003-.000007. The global chi-squared test for haplotype transmission also showed a strong association (chi(2) = 48.84, df = 7, p ",

keywords = "Chromosomes, Human, Pair 8, Female, Frizzled Receptors, Genetic Predisposition to Disease, Genotype, Humans, Male, Polymerase Chain Reaction, Polymorphism, Restriction Fragment Length, Polymorphism, Single Nucleotide, Receptors, G-Protein-Coupled, Schizophrenia",

author = "Jianzhong Yang and Tianmei Si and Yansu Ling and Yan Ruan and Yonghua Han and Xiling Wang and Hongyan Zhang and Qingmei Kong and Xueni Li and Cui Liu and Darong Zhang and Mo Zhou and Yaqin Yu and Shuzeng Liu and Liang Shu and Dalong Ma and Jun Wei and Dai Zhang",

year = "2003",

month = dec,

day = "1",

language = "English",

volume = "54",

pages = "1298--301",

journal = "Biological Psychiatry",

issn = "0006-3223",

publisher = "Elsevier Inc.",

number = "11",

}

TY - JOUR

T1 - Association study of the human FZD3 locus with schizophrenia

AU - Yang, Jianzhong

AU - Si, Tianmei

AU - Ling, Yansu

AU - Ruan, Yan

AU - Han, Yonghua

AU - Wang, Xiling

AU - Zhang, Hongyan

AU - Kong, Qingmei

AU - Li, Xueni

AU - Liu, Cui

AU - Zhang, Darong

AU - Zhou, Mo

AU - Yu, Yaqin

AU - Liu, Shuzeng

AU - Shu, Liang

AU - Ma, Dalong

AU - Wei, Jun

AU - Zhang, Dai

PY - 2003/12/1

Y1 - 2003/12/1

N2 - The FZD3 protein is a transmembrane receptor for secreted Wnt glycoproteins involved in the Wnt signal transduction cascades. The alteration of Wnt signal transduction cascades has been thought to be involved in producing the cytoarchitectural defects observed in schizophrenia. Because the human FZD3 gene is mapped to chromosome 8p21, which is a potential region containing a gene for schizophrenia, it may play a role in conferring susceptibility to the disease. This study was conducted with the detection of three single nucleotide polymorphisms (SNPs) located within the FZD3 locus by using the polymerase chain reaction-based restriction fragment length polymorphism (RFLP) analysis among 246 schizophrenic family trios of Chinese Han descent.The transmission disequilibrium test (TDT) demonstrated that the three SNPs all showed a preferential transmission with a p value ranging from.0003-.000007. The global chi-squared test for haplotype transmission also showed a strong association (chi(2) = 48.84, df = 7, p

AB - The FZD3 protein is a transmembrane receptor for secreted Wnt glycoproteins involved in the Wnt signal transduction cascades. The alteration of Wnt signal transduction cascades has been thought to be involved in producing the cytoarchitectural defects observed in schizophrenia. Because the human FZD3 gene is mapped to chromosome 8p21, which is a potential region containing a gene for schizophrenia, it may play a role in conferring susceptibility to the disease. This study was conducted with the detection of three single nucleotide polymorphisms (SNPs) located within the FZD3 locus by using the polymerase chain reaction-based restriction fragment length polymorphism (RFLP) analysis among 246 schizophrenic family trios of Chinese Han descent.The transmission disequilibrium test (TDT) demonstrated that the three SNPs all showed a preferential transmission with a p value ranging from.0003-.000007. The global chi-squared test for haplotype transmission also showed a strong association (chi(2) = 48.84, df = 7, p

KW - Chromosomes, Human, Pair 8

KW - Female

KW - Frizzled Receptors

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Humans

KW - Male

KW - Polymerase Chain Reaction

KW - Polymorphism, Restriction Fragment Length

KW - Polymorphism, Single Nucleotide

KW - Receptors, G-Protein-Coupled

KW - Schizophrenia

M3 - Article

C2 - 14643098

SN - 0006-3223

VL - 54

SP - 1298

EP - 1301

JO - Biological Psychiatry

JF - Biological Psychiatry

IS - 11

ER -

Association study of the human FZD3 locus with schizophrenia

Abstract

Fingerprint

Dieses zitieren