A study of a genetic association between the PTGS2/PLA2G4A locus and schizophrenia

J Wei; G P Hemmings

doi:10.1016/j.plefa.2003.12.018

A study of a genetic association between the PTGS2/PLA2G4A locus and schizophrenia

J Wei
, G P Hemmings

Publikation: Article › Begutachtung

42 Zitate (Scopus)

Abstract

Six single nucleotide polymorphisms (SNPs) present in the PTGS2/PLA2G4A locus were detected among 118 British family trios of schizophrenia patients. The transmission disequilibrium test showed that SNP4 located in the 5'-flanking region of the PLA2G4A gene was associated with schizophrenia and that the haplotype analysis also showed a genetic association between the PTGS2 gene and schizophrenia. Because these two genes are arranged in a head-to-head configuration and separated by just about 149kb of DNA, they may have a combined effect on susceptibility to schizophrenia in some cases.

Originalsprache	English
Seiten (von - bis)	413-5
Seitenumfang	3
Fachzeitschrift	Prostaglandins Leukotrienes and Essential Fatty Acids
Jahrgang	70
Ausgabenummer	4
DOIs	https://doi.org/10.1016/j.plefa.2003.12.018
Publikationsstatus	Published - Apr. 2004

Zugriff auf Dokument

10.1016/j.plefa.2003.12.018

Dieses zitieren

@article{cf1ba3c85cdc487d843bf6fb9bd6890f,

title = "A study of a genetic association between the PTGS2/PLA2G4A locus and schizophrenia",

abstract = "Six single nucleotide polymorphisms (SNPs) present in the PTGS2/PLA2G4A locus were detected among 118 British family trios of schizophrenia patients. The transmission disequilibrium test showed that SNP4 located in the 5'-flanking region of the PLA2G4A gene was associated with schizophrenia and that the haplotype analysis also showed a genetic association between the PTGS2 gene and schizophrenia. Because these two genes are arranged in a head-to-head configuration and separated by just about 149kb of DNA, they may have a combined effect on susceptibility to schizophrenia in some cases.",

keywords = "Adult, Alleles, Cyclooxygenase 2, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Great Britain, Haplotypes, Humans, Male, Membrane Proteins, Phospholipases A, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Prostaglandin-Endoperoxide Synthases, Schizophrenia",

author = "J Wei and Hemmings, \{G P\}",

year = "2004",

month = apr,

doi = "10.1016/j.plefa.2003.12.018",

language = "English",

volume = "70",

pages = "413--5",

journal = "Prostaglandins Leukotrienes and Essential Fatty Acids",

issn = "0952-3278",

publisher = "Churchill Livingstone",

number = "4",

}

TY - JOUR

T1 - A study of a genetic association between the PTGS2/PLA2G4A locus and schizophrenia

AU - Wei, J

AU - Hemmings, G P

PY - 2004/4

Y1 - 2004/4

N2 - Six single nucleotide polymorphisms (SNPs) present in the PTGS2/PLA2G4A locus were detected among 118 British family trios of schizophrenia patients. The transmission disequilibrium test showed that SNP4 located in the 5'-flanking region of the PLA2G4A gene was associated with schizophrenia and that the haplotype analysis also showed a genetic association between the PTGS2 gene and schizophrenia. Because these two genes are arranged in a head-to-head configuration and separated by just about 149kb of DNA, they may have a combined effect on susceptibility to schizophrenia in some cases.

AB - Six single nucleotide polymorphisms (SNPs) present in the PTGS2/PLA2G4A locus were detected among 118 British family trios of schizophrenia patients. The transmission disequilibrium test showed that SNP4 located in the 5'-flanking region of the PLA2G4A gene was associated with schizophrenia and that the haplotype analysis also showed a genetic association between the PTGS2 gene and schizophrenia. Because these two genes are arranged in a head-to-head configuration and separated by just about 149kb of DNA, they may have a combined effect on susceptibility to schizophrenia in some cases.

KW - Adult

KW - Alleles

KW - Cyclooxygenase 2

KW - European Continental Ancestry Group

KW - Female

KW - Genetic Predisposition to Disease

KW - Great Britain

KW - Haplotypes

KW - Humans

KW - Male

KW - Membrane Proteins

KW - Phospholipases A

KW - Polymerase Chain Reaction

KW - Polymorphism, Single Nucleotide

KW - Prostaglandin-Endoperoxide Synthases

KW - Schizophrenia

U2 - 10.1016/j.plefa.2003.12.018

DO - 10.1016/j.plefa.2003.12.018

M3 - Article

C2 - 15041036

SN - 0952-3278

VL - 70

SP - 413

EP - 415

JO - Prostaglandins Leukotrienes and Essential Fatty Acids

JF - Prostaglandins Leukotrienes and Essential Fatty Acids

IS - 4

ER -

A study of a genetic association between the PTGS2/PLA2G4A locus and schizophrenia

Abstract

Zugriff auf Dokument

Fingerprint

Dieses zitieren