A new class of NO-donor pro-drugs triggered by ¿-glutamyl transpeptidase with potential for reno-selective vasodilatation

Qingzhi Zhang; Agnieszka Kulczynska; David J Webb; Ian L Megson; Nigel P Botting

doi:10.1039/c2cc38382a

A new class of NO-donor pro-drugs triggered by ¿-glutamyl transpeptidase with potential for reno-selective vasodilatation

Qingzhi Zhang
, Agnieszka Kulczynska
, David J Webb
, Ian L Megson
, Nigel P Botting

Publikation: Article › Begutachtung

11 Zitate (Scopus)

Abstract

This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of ¿-glutamyl transpeptidase (¿-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).

Originalsprache	English
Seiten (von - bis)	1389-1391
Seitenumfang	3
Fachzeitschrift	Chemical Communications
Jahrgang	49
Ausgabenummer	14
DOIs	https://doi.org/10.1039/c2cc38382a
Publikationsstatus	Published - 18 Feb. 2013

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10.1039/c2cc38382a

http://www.scopus.com/inward/record.url?eid=2-s2.0-84872738180&partnerID=40&md5=49868bb517891ebacc063da22a3a36e4

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abstract = "This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of ¿-glutamyl transpeptidase (¿-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).",

keywords = "Acute Kidney Injury, Guanidines, Humans, Nitric Oxide, Prodrugs, Vasodilator Agents, gamma-Glutamyltransferase",

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AU - Webb, David J

AU - Megson, Ian L

AU - Botting, Nigel P

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AB - This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of ¿-glutamyl transpeptidase (¿-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).

KW - Acute Kidney Injury

KW - Guanidines

KW - Humans

KW - Nitric Oxide

KW - Prodrugs

KW - Vasodilator Agents

KW - gamma-Glutamyltransferase

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A new class of NO-donor pro-drugs triggered by ¿-glutamyl transpeptidase with potential for reno-selective vasodilatation

Abstract

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