A study of a genetic association between the PTGS2/PLA2G4A locus and schizophrenia

J Wei; G P Hemmings

doi:10.1016/j.plefa.2003.12.018

A study of a genetic association between the PTGS2/PLA2G4A locus and schizophrenia

J Wei
, G P Hemmings

نتاج البحث: Article › مراجعة النظراء

42 اقتباسات (Scopus)

ملخص

Six single nucleotide polymorphisms (SNPs) present in the PTGS2/PLA2G4A locus were detected among 118 British family trios of schizophrenia patients. The transmission disequilibrium test showed that SNP4 located in the 5'-flanking region of the PLA2G4A gene was associated with schizophrenia and that the haplotype analysis also showed a genetic association between the PTGS2 gene and schizophrenia. Because these two genes are arranged in a head-to-head configuration and separated by just about 149kb of DNA, they may have a combined effect on susceptibility to schizophrenia in some cases.

اللغة الأصلية	English
الصفحات (من إلى)	413-5
عدد الصفحات	3
دورية	Prostaglandins Leukotrienes and Essential Fatty Acids
مستوى الصوت	70
رقم الإصدار	4
المعرِّفات الرقمية للأشياء	https://doi.org/10.1016/j.plefa.2003.12.018
حالة النشر	Published - أبريل 2004

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10.1016/j.plefa.2003.12.018

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title = "A study of a genetic association between the PTGS2/PLA2G4A locus and schizophrenia",

abstract = "Six single nucleotide polymorphisms (SNPs) present in the PTGS2/PLA2G4A locus were detected among 118 British family trios of schizophrenia patients. The transmission disequilibrium test showed that SNP4 located in the 5'-flanking region of the PLA2G4A gene was associated with schizophrenia and that the haplotype analysis also showed a genetic association between the PTGS2 gene and schizophrenia. Because these two genes are arranged in a head-to-head configuration and separated by just about 149kb of DNA, they may have a combined effect on susceptibility to schizophrenia in some cases.",

keywords = "Adult, Alleles, Cyclooxygenase 2, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Great Britain, Haplotypes, Humans, Male, Membrane Proteins, Phospholipases A, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Prostaglandin-Endoperoxide Synthases, Schizophrenia",

author = "J Wei and Hemmings, \{G P\}",

year = "2004",

month = apr,

doi = "10.1016/j.plefa.2003.12.018",

language = "English",

volume = "70",

pages = "413--5",

journal = "Prostaglandins Leukotrienes and Essential Fatty Acids",

issn = "0952-3278",

publisher = "Churchill Livingstone",

number = "4",

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TY - JOUR

T1 - A study of a genetic association between the PTGS2/PLA2G4A locus and schizophrenia

AU - Wei, J

AU - Hemmings, G P

PY - 2004/4

Y1 - 2004/4

N2 - Six single nucleotide polymorphisms (SNPs) present in the PTGS2/PLA2G4A locus were detected among 118 British family trios of schizophrenia patients. The transmission disequilibrium test showed that SNP4 located in the 5'-flanking region of the PLA2G4A gene was associated with schizophrenia and that the haplotype analysis also showed a genetic association between the PTGS2 gene and schizophrenia. Because these two genes are arranged in a head-to-head configuration and separated by just about 149kb of DNA, they may have a combined effect on susceptibility to schizophrenia in some cases.

AB - Six single nucleotide polymorphisms (SNPs) present in the PTGS2/PLA2G4A locus were detected among 118 British family trios of schizophrenia patients. The transmission disequilibrium test showed that SNP4 located in the 5'-flanking region of the PLA2G4A gene was associated with schizophrenia and that the haplotype analysis also showed a genetic association between the PTGS2 gene and schizophrenia. Because these two genes are arranged in a head-to-head configuration and separated by just about 149kb of DNA, they may have a combined effect on susceptibility to schizophrenia in some cases.

KW - Adult

KW - Alleles

KW - Cyclooxygenase 2

KW - European Continental Ancestry Group

KW - Female

KW - Genetic Predisposition to Disease

KW - Great Britain

KW - Haplotypes

KW - Humans

KW - Male

KW - Membrane Proteins

KW - Phospholipases A

KW - Polymerase Chain Reaction

KW - Polymorphism, Single Nucleotide

KW - Prostaglandin-Endoperoxide Synthases

KW - Schizophrenia

U2 - 10.1016/j.plefa.2003.12.018

DO - 10.1016/j.plefa.2003.12.018

M3 - Article

C2 - 15041036

SN - 0952-3278

VL - 70

SP - 413

EP - 415

JO - Prostaglandins Leukotrienes and Essential Fatty Acids

JF - Prostaglandins Leukotrienes and Essential Fatty Acids

IS - 4

ER -

A study of a genetic association between the PTGS2/PLA2G4A locus and schizophrenia

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