A novel S-nitrosothiol causes prolonged and selective inhibition of platelet adhesion at sites of vascular injury

Mark R Miller; Inderraj S Hanspal; Patrick W F Hadoke; David E Newby; Adriano G Rossi; David J Webb; Ian L Megson

A novel S-nitrosothiol causes prolonged and selective inhibition of platelet adhesion at sites of vascular injury

Mark R Miller
, Inderraj S Hanspal
, Patrick W F Hadoke
, David E Newby
, Adriano G Rossi
, David J Webb
, Ian L Megson

نتاج البحث: Article › مراجعة النظراء

14 اقتباسات (Scopus)

ملخص

Platelet adhesion to areas of endothelial denudation following angioplasty is an important factor contributing to the limitations of this technique. Lipophilic S-nitrosothiols like S-nitroso-N-valerylpenicillamine (SNVP) are novel nitric oxide (NO) donor drugs with anti-platelet and vasodilator properties that are selective for areas of endothelial denudation. Here we assess the inhibitory effect of SNVP on platelet adhesion to angioplastied rabbit carotid arteries.

اللغة الأصلية	English
الصفحات (من إلى)	853-60
عدد الصفحات	8
دورية	Cardiovascular Research
مستوى الصوت	57
رقم الإصدار	3
حالة النشر	Published - 2003

قم بذكر هذا

@article{021a74d610c54c5e9a7e8bc79c5fe890,

title = "A novel S-nitrosothiol causes prolonged and selective inhibition of platelet adhesion at sites of vascular injury",

abstract = "Platelet adhesion to areas of endothelial denudation following angioplasty is an important factor contributing to the limitations of this technique. Lipophilic S-nitrosothiols like S-nitroso-N-valerylpenicillamine (SNVP) are novel nitric oxide (NO) donor drugs with anti-platelet and vasodilator properties that are selective for areas of endothelial denudation. Here we assess the inhibitory effect of SNVP on platelet adhesion to angioplastied rabbit carotid arteries.",

author = "Miller, \{Mark R\} and Hanspal, \{Inderraj S\} and Hadoke, \{Patrick W F\} and Newby, \{David E\} and Rossi, \{Adriano G\} and Webb, \{David J\} and Megson, \{Ian L\}",

year = "2003",

language = "English",

volume = "57",

pages = "853--60",

journal = "Cardiovascular Research",

issn = "0008-6363",

publisher = "Oxford University Press",

number = "3",

}

TY - JOUR

T1 - A novel S-nitrosothiol causes prolonged and selective inhibition of platelet adhesion at sites of vascular injury

AU - Miller, Mark R

AU - Hanspal, Inderraj S

AU - Hadoke, Patrick W F

AU - Newby, David E

AU - Rossi, Adriano G

AU - Webb, David J

AU - Megson, Ian L

PY - 2003

Y1 - 2003

N2 - Platelet adhesion to areas of endothelial denudation following angioplasty is an important factor contributing to the limitations of this technique. Lipophilic S-nitrosothiols like S-nitroso-N-valerylpenicillamine (SNVP) are novel nitric oxide (NO) donor drugs with anti-platelet and vasodilator properties that are selective for areas of endothelial denudation. Here we assess the inhibitory effect of SNVP on platelet adhesion to angioplastied rabbit carotid arteries.

AB - Platelet adhesion to areas of endothelial denudation following angioplasty is an important factor contributing to the limitations of this technique. Lipophilic S-nitrosothiols like S-nitroso-N-valerylpenicillamine (SNVP) are novel nitric oxide (NO) donor drugs with anti-platelet and vasodilator properties that are selective for areas of endothelial denudation. Here we assess the inhibitory effect of SNVP on platelet adhesion to angioplastied rabbit carotid arteries.

M3 - Article

C2 - 12618247

SN - 0008-6363

VL - 57

SP - 853

EP - 860

JO - Cardiovascular Research

JF - Cardiovascular Research

IS - 3

ER -

A novel S-nitrosothiol causes prolonged and selective inhibition of platelet adhesion at sites of vascular injury

ملخص

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