A new class of NO-donor pro-drugs triggered by ¿-glutamyl transpeptidase with potential for reno-selective vasodilatation

Qingzhi Zhang; Agnieszka Kulczynska; David J Webb; Ian L Megson; Nigel P Botting

doi:10.1039/c2cc38382a

A new class of NO-donor pro-drugs triggered by ¿-glutamyl transpeptidase with potential for reno-selective vasodilatation

Qingzhi Zhang
, Agnieszka Kulczynska
, David J Webb
, Ian L Megson
, Nigel P Botting

نتاج البحث: Article › مراجعة النظراء

11 اقتباسات (Scopus)

ملخص

This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of ¿-glutamyl transpeptidase (¿-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).

اللغة الأصلية	English
الصفحات (من إلى)	1389-1391
عدد الصفحات	3
دورية	Chemical Communications
مستوى الصوت	49
رقم الإصدار	14
المعرِّفات الرقمية للأشياء	https://doi.org/10.1039/c2cc38382a
حالة النشر	Published - 18 فبراير 2013

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10.1039/c2cc38382a

http://www.scopus.com/inward/record.url?eid=2-s2.0-84872738180&partnerID=40&md5=49868bb517891ebacc063da22a3a36e4

قم بذكر هذا

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title = "A new class of NO-donor pro-drugs triggered by ¿-glutamyl transpeptidase with potential for reno-selective vasodilatation",

abstract = "This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of ¿-glutamyl transpeptidase (¿-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).",

keywords = "Acute Kidney Injury, Guanidines, Humans, Nitric Oxide, Prodrugs, Vasodilator Agents, gamma-Glutamyltransferase",

author = "Qingzhi Zhang and Agnieszka Kulczynska and Webb, \{David J\} and Megson, \{Ian L\} and Botting, \{Nigel P\}",

note = "cited By (since 1996)0",

year = "2013",

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doi = "10.1039/c2cc38382a",

language = "English",

volume = "49",

pages = "1389--1391",

journal = "Chemical Communications",

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T1 - A new class of NO-donor pro-drugs triggered by ¿-glutamyl transpeptidase with potential for reno-selective vasodilatation

AU - Zhang, Qingzhi

AU - Kulczynska, Agnieszka

AU - Webb, David J

AU - Megson, Ian L

AU - Botting, Nigel P

N1 - cited By (since 1996)0

PY - 2013/2/18

Y1 - 2013/2/18

N2 - This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of ¿-glutamyl transpeptidase (¿-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).

AB - This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of ¿-glutamyl transpeptidase (¿-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).

KW - Acute Kidney Injury

KW - Guanidines

KW - Humans

KW - Nitric Oxide

KW - Prodrugs

KW - Vasodilator Agents

KW - gamma-Glutamyltransferase

U2 - 10.1039/c2cc38382a

DO - 10.1039/c2cc38382a

M3 - Article

C2 - 23322269

SN - 1364-548X

VL - 49

SP - 1389

EP - 1391

JO - Chemical Communications

JF - Chemical Communications

IS - 14

ER -

A new class of NO-donor pro-drugs triggered by ¿-glutamyl transpeptidase with potential for reno-selective vasodilatation

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